Compare Coumadin vs. Eliquis

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Coumadin (warfarin)

Prescription only

Eliquis (apixaban)

Prescription only
Prevents blood clots.

Coumadin (warfarin) is a cheap and effective medicine that prevents new blood clots. It requires regular blood tests and you'll need to eat, exercise, and take your medicines consistently.

5.2/ 7 average rating with 513 reviewsforCoumadin
Prevents blood clots.

Eliquis (apixaban) is an effective way to prevent blood clots from forming in your veins, but you have to take it twice a day, and your doctor might have to change the dose a lot.

5.3/ 7 average rating with 19 reviewsforEliquis
Upsides
  • Coumadin (warfarin) is available as a generic, so it should be less expensive than the brand version.
  • In case you start bleeding too much while using Coumadin (warfarin), your doctor can give you another drug that reverses Coumadin (warfarin)'s effects.
  • Coumadin (warfarin) comes in numerous strengths.
  • Coumadin (warfarin) has been around for a long time and is one of the most commonly used 'blood thinner' medicines.
  • Eliquis (apixaban) is very effective in reducing the risk of stroke in people with atrial fibrilation or other clotting disorders.
  • You don't need to have regular blood tests on Eliquis (apixaban), and you don't have to regulate your diet like other blood thinners.
  • If you've had clots in your legs or lungs before, Eliquis (apixaban) can lower the risk of these forming again.
Downsides
  • Raises your risk of bleeding and bruising.
  • Requires regular blood work, such as an INR, to make sure Coumadin (warfarin) is working correctly.
  • Your daily dose of Coumadin (warfarin) can change if you change your diet, exercise patterns, or use of alcohol.
  • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
  • You can bruise easier and if you cut yourself, it'll take longer to stop the bleeding. Always look for signs of internal bleeding, such as dark urine or bloody stools.
  • Can't be used if you have artificial heart valves.
  • Never stop taking Eliquis (apixaban) without talking to your doctor first.
  • Eliquis (apixaban) isn't available as a generic, so it can be expensive.
  • If you've taken too much Eliquis (apixaban) and you're bleeding, it can be harder to treat compared to other blood thinners.
Used for
Dosage forms
  • Pill
  • Pill
Price
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$4
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$405.63
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Reviews
513 
61%
think this treatment is worth it
54%
think this treatment works well
21%
think this treatment is a hassle

Have you used Coumadin (warfarin)?

Leave a review
19 
47%
think this treatment is worth it
58%
think this treatment works well
21%
think this treatment is a hassle

Have you used Eliquis (apixaban)?

Leave a review
Side effects
The Coumadin (warfarin) FDA package insert doesn’t have numbers about how common side effects are.
1possible side effects
  • Major bleed
    2%
See more detailed side effects
Risks and warnings
  • Life threatening bleeding

    Coumadin (warfarin) dose too high

    ...and 8 more risk factors

  • Harm to fetus

    Women of childbearing age

See more detailed risks and warnings
  • Increased risk of stroke or blood clots from early discontinuation

    Stopping Eliquis (apixaban) prematurely

  • Paralysis in the spine

    Spinal puncture (spinal tap)

    ...and 3 more risk factors

  • Increased risk of stroke or bleeding

    Artificial heart valve

  • Increased side effects in kidney or liver conditions

    Current kidney problems

    ...and 1 more risk factors

See more detailed risks and warnings