Compare Coumadin vs. Eliquis

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Coumadin
(warfarin)

Eliquis
(apixaban)

Prevents blood clots. Coumadin (warfarin) is a cheap and effective medicine that prevents new blood clots. It requires regular blood tests and you'll need to eat, exercise, and take your medicines consistently.Prevents blood clots. Eliquis (Apixaban) is an easy to use and effective way to prevent blood clots from forming in your veins.
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Prices and coupon for 30 (5mg) tablets of warfarin
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Prices and coupon for 60 (5mg) tablets of apixaban
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.15Coumadin
Reviews for Coumadin (warfarin)
61%
of people (All ages) say Coumadin (warfarin) is worth it
54%
say it works well
21%
say it's a big hassle
513 reviews
Have you used Coumadin (warfarin)?
Worth itNot sureNot worth it

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Have you used Eliquis (apixaban)?
Worth itNot sureNot worth it
Side effects
CoumadinEliquis

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »
  • Bleeding 2%
  • Major bleed 2%
  • Nonmajor bleeding 2%
  • All bleed 12%
  • All bleeding 7%
  • Nausea 3%
  • Low red blood cells 3%
  • Nosebleed 3%
  • Bruise 2%
  • Blood in urine 2%
More Eliquis side effects »
How it works
CoumadinEliquis
Coumadin (warfarin) prevents blood clots from forming. It doesn't break up clots that already exist. It can only stop new ones from forming or old ones from getting bigger.Eliquis (Apixaban) is a factor Xa inhibitor anticoagulant and prevents the formation of blood clots in your veins.
Type of medication
CoumadinEliquis
Prescription only
Prescription only
Available as
CoumadinEliquis
  • Pill
  • Pill
Used for
CoumadinEliquis
Risk factors for serious side effects
CoumadinEliquis
  • Coumadin (warfarin) dose too high
  • Age greater than 65 year
  • History of stomach bleeding
  • High blood pressure
  • Kidney or liver problems
  • Drug interactions
  • Change in lifestyle or diet
  • Alcohol use
  • Certain genetic factors
  • Women of childbearing age
      Detailed Coumadin (warfarin) risks & warnings »
      • Stopping Eliquis (Apixaban) early
      • Spinal puncture (spinal tap)
      • Getting anesthesia in the spine (epidural anesthesia)
      • History of bleeding problems
      • Severe high blood pressure
      • Older age
      • Artificial heart valve
      • Current kidney problems
      • Current liver problems
      Detailed Eliquis (apixaban) risks & warnings »
      Pregnancy

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Interactions
      CoumadinEliquis
      • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
      • Coumadin (warfarin) interacts with many drugs and supplements. This can increase your risk of bleeding or of developing a new blood clot. If you start a new medication or change your diet, let your doctor know so they can change your dose if necessary.
      No interactions related info.
      Food
      CoumadinEliquis
      No food related info.
      • Take twice a day, with or without food, at the same time each day.
      Kidneys and liver
      CoumadinEliquis
      No kidneys and liver related info.
      • Eliquis (Apixaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to prevent increased risk for side effects.
      Upsides and benefits
      CoumadinEliquis
      • Coumadin (warfarin) is available as a generic, so it should be less expensive than the brand version.
      • In case you start bleeding too much while using Coumadin (warfarin), your doctor can give you another drug that reverses Coumadin (warfarin)'s effects.
      • Coumadin (warfarin) comes in numerous strengths.
      • Coumadin (warfarin) has been around for a long time and is one of the most commonly used 'blood thinner' medicines.
      • Eliquis (Apixaban) is very effective in reducing the threat of stroke in people with Afib or other clotting disorders.
      • Eliquis (Apixaban) doesn't require regular blood testing and doesn't have dietary restrictions.
      • If you've had clots in your legs or lungs before, Eliquis (Apixaban) can lower the risk of these forming again.
      Downsides and risks
      CoumadinEliquis
      • Raises your risk of bleeding and bruising.
      • Requires regular blood work, such as an INR, to make sure Coumadin (warfarin) is working correctly.
      • Your daily dose of Coumadin (warfarin) can change if you change your diet, exercise patterns, or use of alcohol.
      • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
      • You can bruise easier and if you cut yourself, it'll take longer to stop the bleeding. Always look for signs of internal bleeding, such as dark urine or blood in your stool.
      • Can't be used if you have artificial heart valves.
      • Never stop taking Eliquis (Apixaban) without talking to your doctor first.
      • Eliquis (Apixaban) isn't available as a generic, so it can be pricey.
      Tips from our pharmacists for people taking the medication
      CoumadinEliquis
      • Prevents clots from forming or getting bigger. It doesn't break up clots that already exist.
      • Take Coumadin (warfarin) exactly as your doctor tells you.
      • Once you're taking Coumadin (warfarin), it'll take longer for your body to heal if you get cut or bruised. Call your doctor if you notice any unusual bleeding or bruising.
      • Carry a list of your medications with you or wear a medical bracelet that says you're on Coumadin (warfarin) in case you have a medical emergency.
      • Your doctor will check your blood regularly for the first few months that you're taking Coumadin (warfarin).
      • To get the best results, don't fall behind on taking your other medicines and eat the same amount of vegetables each day.
      • Take twice a day, with or without food, at the same time each day.
      • Needs to be stopped prior to dental procedures or surgery.
      • You can bruise easier and if you have a cut, it can take longer for bleeding to stop.
      • Do not take with other drugs that affect your blood, like aspirin, ibuprofen, warfarin, or SSRIs.
      • Call a doctor immediately if you have dizziness, weakness, or a really bad headache.
      Learn more
      More about CoumadinSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Coumadin (warfarin)?
      Worth itNot sureNot worth it
      More about EliquisSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Eliquis (apixaban)?
      Worth itNot sureNot worth it