Compare Coumadin vs. Lovenox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Coumadin
(warfarin)

Lovenox
(enoxaparin)

Prevents blood clots. Coumadin (warfarin) is a cheap and effective medicine that prevents new blood clots. It requires regular blood tests and you'll need to eat, exercise, and take your medicines consistently.Prevents blood clots. Lovenox (Enoxaparin) is a good anticoagulant that reduces the risk of death or bleeding, and blood clots are less likely to happen. However, it is only available as an injection which isn't great if you're afraid of needles.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.15Coumadin
Reviews for Coumadin
61%
of people (All ages) say Coumadin is worth it
54%
say it works well
21%
say it's a big hassle
513 reviews
Have you used Coumadin (warfarin)?
Worth itNot sureNot worth it
Reviews for Lovenox
63%
-2% worse vs. Coumadin
63%
-9% worse vs. Coumadin
16%
-5% worse vs. Coumadin
Have you used Lovenox (enoxaparin)?
Worth itNot sureNot worth it
Side effects
CoumadinLovenox

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »
  • Injection site hematoma 7%
  • Hemorrhage 7%
  • Major hemorrhage 4%
  • Nausea 1%
  • Confusion 1%
  • Fever 2%
More Lovenox side effects »
How it works
CoumadinLovenox
Coumadin (warfarin) prevents blood clots from forming. It doesn't break up clots that already exist. It can only stop new ones from forming or old ones from getting bigger.Lovenox (Enoxaparin) is an anticoagulant that prevents certain blood-clotting proteins from working. By stopping blood clots from forming, there's a lower chance of having a stroke or blood clots travel to your lungs.
Type of medication
CoumadinLovenox
Prescription onlyPrescription only
Available as
CoumadinLovenox
  • Pill
  • Injection
Used for
CoumadinLovenox
Risk factors for serious side effects
CoumadinLovenox
  • Coumadin (warfarin) dose too high
  • Age greater than 65 year
  • History of stomach bleeding
  • High blood pressure
  • Kidney or liver problems
Detailed Coumadin (warfarin) risks & warnings »
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • Taking NSAIDs or other blood thinning medicines
  • History of bleeding problems
  • Severe high blood pressure
Detailed Lovenox (enoxaparin) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
CoumadinLovenox
  • Coumadin (warfarin) interacts with many drugs and supplements. This can increase your risk of bleeding or of developing a new blood clot. If you start a new medication or change your diet, let your doctor know so they can change your dose if necessary.
  • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
No interactions related info.
Food
CoumadinLovenox
No food related info.
  • Available in generic so it can be cheaper than other "blood thinners".
Upsides and benefits
CoumadinLovenox
  • Coumadin (warfarin) is available as a generic, so it should be less expensive than the brand version.
  • In case you start bleeding too much while using Coumadin (warfarin), your doctor can give you another drug that reverses Coumadin (warfarin)'s effects.
  • Coumadin (warfarin) comes in numerous strengths.
  • Coumadin (warfarin) has been around for a long time and is one of the most commonly used 'blood thinner' medicines.
  • In a study that compared Lovenox (Enoxaparin) to other medications used to stop blood clots, there was a lower risk of clots coming back, with similar rates of major bleeding and mortality.
  • You don't need to go in for lab tests to check whether it's working, unlike other medications like warfarin that require regular blood draws.
  • Available in generic so it can be cheaper than other "blood thinners".
  • Good option if you're pregnant or have cancer.
Downsides and risks
CoumadinLovenox
  • Raises your risk of bleeding and bruising.
  • Requires regular blood work, such as an INR, to make sure Coumadin (warfarin) is working correctly.
  • Your daily dose of Coumadin (warfarin) can change if you change your diet, exercise patterns, or use of alcohol.
  • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
  • It is only available as an injection, so it's not great if you're afraid of needles.
  • While surprise bleeding episodes can be treated while taking Lovenox (Enoxaparin), they won't completely work.
  • It doesn't work as well as other medications for "thinning the blood" if you are overweight, underweight, or if you have kidney disease.
Tips from our pharmacists for people taking the medication
CoumadinLovenox
  • Prevents clots from forming or getting bigger. It doesn't break up clots that already exist.
  • Take Coumadin (warfarin) exactly as your doctor tells you.
  • Once you're taking Coumadin (warfarin), it'll take longer for your body to heal if you get cut or bruised. Call your doctor if you notice any unusual bleeding or bruising.
  • Carry a list of your medications with you or wear a medical bracelet that says you're on Coumadin (warfarin) in case you have a medical emergency.
  • Your doctor will check your blood regularly for the first few months that you're taking Coumadin (warfarin).
  • To get the best results, don't fall behind on taking your other medicines and eat the same amount of vegetables each day.
  • Rotate the spot where you inject Lovenox (Enoxaparin) every day.
  • While on this, it can take longer to stop bleeding and you are more likely to bruise or bleed more easily.
  • Avoid taking certain anti-inflammatory drugs (like NSAIDs) because they can make you more likely to bleed.
  • Can cause swelling in your legs, diarrhea, and nausea.
Learn more
More about CoumadinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Coumadin (warfarin)?
Worth itNot sureNot worth it
More about LovenoxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lovenox (enoxaparin)?
Worth itNot sureNot worth it