Compare Coumadin vs. Lovenox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Coumadin
(Warfarin)

Lovenox
(Enoxaparin)

Prevents blood clots. Coumadin (Warfarin) is an old, cheap, and effective medicine to prevent blood clots, but it requires some monitoring, dose adjustments, and even lifestyle changes.Prevents blood clots. Lovenox (Enoxaparin) is a good anticoagulant that reduces the risk of death or bleeding, and blood clots are less likely to happen. However, it is only available as an injection which isn't great if you're afraid of needles.
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Reviews & ratings
Button Group. All currently active
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5.146484375Coumadin
Reviews for Coumadin (Warfarin)
61%
of people say Coumadin (Warfarin) is worth it
54%
say it works well
21%
say it's a big hassle

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Side effects
CoumadinLovenox

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »
  • Injection site hematoma 7%
  • Fever 2%
  • Confusion 1%
  • Nausea 1%
More Lovenox side effects »
How it works
CoumadinLovenox
Coumadin (Warfarin) is an anticoagulant blood thinner. It lowers chemicals called clotting factors so that it's harder for your body to form blood clots.Lovenox (Enoxaparin) is an anticoagulant that prevents certain blood-clotting proteins from working. By stopping blood clots from forming, there's a lower chance of having a stroke or blood clots travel to your lungs.
Type of medication
CoumadinLovenox
Anticoagulant
Vitamin K antagonist
Prescription only
Anticoagulant
Heparin
Prescription only
Available as
CoumadinLovenox
  • Pill
  • Injection
Used for (click to learn more)
CoumadinLovenox
Risk factors for serious side effects
CoumadinLovenox
  • Dose too high
  • Age greater than 65
  • History of gastrointestinal bleeding
  • High blood pressure
  • Kidney or liver problems
  • Drug interactions
  • Change in lifestyle or diet
  • Illnesses
  • Alcohol
  • Certain genetic makeup
    • Women of childbearing age
    Detailed Coumadin (Warfarin) risks & warnings »
    • Spinal puncture (spinal tap)
    • Getting anesthesia in the spine (epidural anesthesia)
    • Taking NSAIDs or other blood thinning medicines
    • History of bleeding problems
    • Severe high blood pressure
    • Older age
    • Stopping Lovenox (Enoxaparin) early
    • Heparin-induced thrombocytopenia
    Detailed Lovenox (Enoxaparin) risks & warnings »
    Pregnancy category
    CoumadinLovenox
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    Alcohol
    • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
    No specific alcohol-related info.
    Food
    • Eat foods containing consistent amounts of Vitamin K.
    No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.
    • It doesn't work as well as other medications for "thinning the blood" if you are overweight, underweight, or if you have kidney disease.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    CoumadinLovenox
    • Oral blood-thinning medicine that prevents blood clots from forming or getting bigger.
    • Prevents complications of blood clots that can cause extreme discomfort or death. Examples include stroke (blood clots in the brain), pulmonary embolism (blood clots in the lungs causing trouble breathing), or deep vein thrombosis (blood clots in the legs causing pain and blood vessel damage).
    • Has an antidote, Vitamin K, in case of a major accidental bleeding.
    • Coumadin (Warfarin) has been around for a long time, so we know a lot about how well it works and what the risks are.
    • It's dirt cheap.
    • In a study that compared Lovenox (Enoxaparin) to other medications used to stop blood clots, there was a lower risk of clots coming back, with similar rates of major bleeding and mortality.
    • You don't need to go in for lab tests to check whether it's working, unlike other medications like warfarin that require regular blood draws.
    • Available in generic so it can be cheaper than other "blood thinners".
    • Good option if you're pregnant or have cancer.
    Downsides and risks
    CoumadinLovenox
    • Raises your risk of bleeding and bruising.
    • Requires routine blood testing (called an INR) to see how well the medicine is working for you and to make the dose just right for you.
    • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
    • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
    • It is only available as an injection, so it's not great if you're afraid of needles.
    • While surprise bleeding episodes can be treated while taking Lovenox (Enoxaparin), they won't completely work.
    • It doesn't work as well as other medications for "thinning the blood" if you are overweight, underweight, or if you have kidney disease.
    Tips from our pharmacists for people taking the medication
    CoumadinLovenox
    • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
    • The amount you need depends on your diet, other medical problems, and genes.
    • Take it exactly as instructed.
    • Can raise your risk of bleeding or bruising.
    • Requires regular blood tests to get your dose right.
    • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
    • Eat foods containing consistent amounts of Vitamin K.
    • Tell your doctor immediately if you fell or if you have unusual bleeding, bruising, swelling, or changes in vision and coordination.
    • Get a medical bracelet so that people know you're on a blood thinner during an emergency situation.
    • Rotate the spot where you inject Lovenox (Enoxaparin) every day.
    • While on this, it can take longer to stop bleeding and you are more likely to bruise or bleed more easily.
    • Avoid taking certain anti-inflammatory drugs (like NSAIDs) because they can make you more likely to bleed.
    • Can cause swelling in your legs, diarrhea, and nausea.
    Learn more
    More about CoumadinSide effectsReviews & ratingsAlternativesFDA package insert
    More about LovenoxSide effectsReviews & ratingsAlternativesFDA package insert