Compare Coumadin vs. Xarelto

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Coumadin (warfarin)

Prescription only

Xarelto (rivaroxaban)

Prescription only
Prevents blood clots.

Coumadin (warfarin) is a cheap and effective medicine that prevents new blood clots. It requires regular blood tests and you'll need to eat, exercise, and take your medicines consistently.

5.2/ 7 average rating with 513 reviewsforCoumadin
Prevents blood clots.

Xarelto (rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. However, it can be expensive and there's no way to reverse the medication's effects.

4.8/ 7 average rating with 22 reviewsforXarelto
Upsides
  • Coumadin (warfarin) is available as a generic, so it should be less expensive than the brand version.
  • In case you start bleeding too much while using Coumadin (warfarin), your doctor can give you another drug that reverses Coumadin (warfarin)'s effects.
  • Coumadin (warfarin) comes in numerous strengths.
  • Coumadin (warfarin) has been around for a long time and is one of the most commonly used 'blood thinner' medicines.
  • Studies show that Xarelto (rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and stopping clots from froming.
  • Xarelto (rivaroxaban) doesn't require regular blood tests or frequent dose changes.
  • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
Downsides
  • Raises your risk of bleeding and bruising.
  • Requires regular blood work, such as an INR, to make sure Coumadin (warfarin) is working correctly.
  • Your daily dose of Coumadin (warfarin) can change if you change your diet, exercise patterns, or use of alcohol.
  • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
  • Xarelto (rivaroxaban) can increase your risk of bleeding, so call your doctor right away if you see blood in your spit, urine, or stool (look for black, tarry stools or bright red blood).
  • Xarelto (rivaroxaban) isn't available as a generic medication.
  • There are no antidotes to stop bleeding caused by taking too much Xarelto (rivaroxaban).
  • You can't take Xarelto (rivaroxaban) if you are pregnant.
Used for
Dosage forms
  • Pill
  • Pill
Price
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$4
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$405.29
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Reviews
513 
61%
think this treatment is worth it
54%
think this treatment works well
21%
think this treatment is a hassle

Have you used Coumadin (warfarin)?

Leave a review
22 
45%
think this treatment is worth it
45%
think this treatment works well
9%
think this treatment is a hassle

Have you used Xarelto (rivaroxaban)?

Leave a review
Side effects
The Coumadin (warfarin) FDA package insert doesn’t have numbers about how common side effects are.
2possible side effects
  • Major bleeding needing transfusion
    4%
  • Bleeding in the stomach & intestines
    2%
See more detailed side effects
Risks and warnings
  • Life threatening bleeding

    Coumadin (warfarin) dose too high

    ...and 8 more risk factors

  • Harm to fetus

    Women of childbearing age

See more detailed risks and warnings
  • Blood clots and stroke

    Stopping Xarelto (rivaroxaban) too soon

    ...and 1 more risk factors

  • Blood clot in the spine

    Spinal puncture (spinal tap)

    ...and 1 more risk factors

  • Unusual bleeding

    History of bleeding problems

    ...and 4 more risk factors

  • Increased side effects

    Current kidney problems

    ...and 1 more risk factors

See more detailed risks and warnings