Compare Crestor vs. Atorvastatin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Crestor
(Rosuvastatin)

Lipitor
(Atorvastatin)

Lowers cholesterol. Crestor (Rosuvastatin) is one of the most effective statins to improve cholesterol, but the brand name medication is expensive. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.Lowers cholesterol. Lipitor (Atorvastatin) is a good medication to improve your cholesterol. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.017333333333333Crestor
Reviews for Crestor (Rosuvastatin)
61%
of people (All ages) say Crestor (Rosuvastatin) is worth it
47%
say it works well
15%
say it's a big hassle
750 reviews
Have you used Crestor (Rosuvastatin)?
Worth itNot sureNot worth it
Reviews for Lipitor (Atorvastatin)
63%
+2% vs. Crestor (Rosuvastatin)
51%
+4% vs. Crestor (Rosuvastatin)
13%
+2% vs. Crestor (Rosuvastatin)
1367 reviews
Have you used Lipitor (Atorvastatin)?
Worth itNot sureNot worth it
Side effects
CrestorAtorvastatin
  • Headache 4%
  • Constipation 3%
  • Joint pain 3%
  • Nausea 3%
  • Muscle weakness 2%
  • Muscle pain 1%
  • Dizziness 1%
  • Diabetes mellitus 1%
More Crestor side effects »
  • Diarrhea 8%
  • Common cold 5%
  • Muscle pain 5%
  • Joint pain 5%
  • Nausea 3%
  • Pain in extremity 3%
  • Urinary tract infection 2%
  • Sleep difficulty 2%
  • Muscle spasms 2%
  • Throat pain 2%
More Atorvastatin side effects »
How it works
CrestorAtorvastatin
Crestor (Rosuvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).Lipitor (Atorvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).
Type of medication
CrestorAtorvastatin
Cholesterol-lowering
Statin
Prescription only
Cholesterol-lowering
Statin
Prescription only
Available as
CrestorAtorvastatin
  • Pill
  • Pill
Used for (click to learn more)
CrestorAtorvastatin
Risk factors for serious side effects
CrestorAtorvastatin
    • Heavy alcohol use
    • Prior history of chronic liver disease
    • Pregnancy
    Detailed Crestor (Rosuvastatin) risks & warnings »
      • Heavy alcohol use
      • Prior history of chronic liver disease
      • Pregnancy
          Detailed Lipitor (Atorvastatin) risks & warnings »
          Pregnancy

          Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

          Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

          Alcohol
          CrestorAtorvastatin
          • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
          • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
          Kidneys and liver
          CrestorAtorvastatin
          • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
          • People on Crestor (Rosuvastatin) have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
          • Liver damage has been reported in people who take Crestor (Rosuvastatin). If you notice dark urine or yellowing of the eyes or skin, talk to your doctor. Your doctor may monitor your liver periodically.
          • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
          • People on Lipitor (Atorvastatin) have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
          • Liver damage has been reported in people who take Lipitor (Atorvastatin). If you notice dark urine or yellowing of the eyes or skin, talk to your prescriber. Your doctor may monitor your liver periodically.
          Upsides and benefits
          CrestorAtorvastatin
          • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as hardening of the arteries.
          • In clinical studies, Crestor has the strongest effect on lowering "bad" cholesterol compared to other statins.
          • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
          • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
          • One of the strongest cholesterol-lowering statin medications.
          • A good option for people who have high cholesterol and diabetes.
          • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
          • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
          Downsides and risks
          CrestorAtorvastatin
          • Even with a generic available in 2016, can be expensive.
          • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
          • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
          • Not safe to use if you're pregnant.
          • Eating a lot of grapefruit can raise your risk of liver damage.
          • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
          • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
          • Not safe to use if you're pregnant.
          Tips from our pharmacists for people taking the medication
          CrestorAtorvastatin
          • Don't take antacids for at least 2 hours before and after taking this medicine.
          • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
          • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
          • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
          • Avoid grapefruit and grapefruit juice while taking this medicine.
          • Tell your doctor if you develop sudden muscle pain, fever or weakness.
          • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
          • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
          Learn more
          More about CrestorSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Crestor (Rosuvastatin)?
          Worth itNot sureNot worth it
          More about AtorvastatinSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Lipitor (Atorvastatin)?
          Worth itNot sureNot worth it