Compare Crestor vs. Atorvastatin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Crestor
(rosuvastatin)

Lipitor
(atorvastatin)

Lowers cholesterol. Crestor (rosuvastatin) is one of the most effective statins to improve cholesterol. It's also available as a generic.Lowers cholesterol. Lipitor (atorvastatin) improves your cholesterol levels and is a common first treatment for people with high cholesterol or heart disease.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.02Crestor
Reviews for Crestor
60%
of people (All ages) say Crestor is worth it
47%
say it works well
15%
say it's a big hassle
751 reviews
Have you used Crestor (rosuvastatin)?
Worth itNot sureNot worth it
Reviews for Atorvastatin
63%
-3% worse vs. Crestor
51%
-4% worse vs. Crestor
13%
-2% worse vs. Crestor
1377 reviews
Have you used Lipitor (atorvastatin)?
Worth itNot sureNot worth it
Side effects
CrestorAtorvastatin
  • Headache 1%
  • Nausea 1%
  • Muscle pain 2%
  • Joint pain 1%
  • Diabetes mellitus 1%
  • Dizziness 1%
More Crestor side effects »
  • Diarrhea 1%
  • Indigestion 1%
  • Muscle spasms 1%
  • Muscle pain 1%
More Atorvastatin side effects »
How it works
CrestorAtorvastatin
Crestor (rosuvastatin) is a statin medication that changes the amount of cholesterol your body makes. It lowers "bad" cholesterol (LDL) and improves your "good" cholesterol (HDL) levels.Lipitor (atorvastatin) is a cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).
Type of medication
CrestorAtorvastatin
Prescription onlyPrescription only
Available as
CrestorAtorvastatin
  • Pill
  • Pill
Used for
CrestorAtorvastatin
Risk factors for serious side effects
CrestorAtorvastatin
  • Taking Coumadin (warfarin)
  • Age 65 or older
  • Taking higher doses of Crestor (rosuvastatin)
  • Diabetes
  • Heavy alcohol use
Detailed Crestor (rosuvastatin) risks & warnings »
  • Heavy alcohol use
  • Prior history of chronic liver disease
  • Pregnancy
  • History of hemorrhagic strokes
Detailed Lipitor (atorvastatin) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Alcohol
CrestorAtorvastatin
  • Don't have more than 2 glasses of alcohol a day since Crestor (rosuvastatin) can cause liver damage.
  • You're more likely to have side effects if you're a female, are 65 years or older, drink alcohol every day, or take more than one medicine for cholesterol.
  • You're at higher risk for these side effects if you are a female, are 65 years or older, or drink more than two alcoholic drinks a day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
Kidneys and liver
CrestorAtorvastatin
  • People on Crestor (rosuvastatin) have reported muscle pain which can lead to muscle or kidney damage. This is more likely to happen if you're older and if you're taking higher doses of Crestor (rosuvastatin). If you suddenly feel severe muscle pain or weakness and you haven't been exercising, stop taking Crestor (rosuvastatin) and talk to your doctor right away.
  • Crestor (rosuvastatin) can cause liver damage. If your urine is darker than normal or if you notice a yellow color in your eyes or skin, talk to your doctor. Your doctor may run some tests to see how your liver is working.
  • People with liver disease, kidney disease, or diabetes are also more likely to have side effects from Crestor (rosuvastatin).
  • People on Lipitor (atorvastatin) have reported muscle pain, which may lead to muscle and kidney damage. This is more likely to happen if you're older and you're taking higher doses of Lipitor (atorvastatin). If you suddenly feel muscle pain or weakness and you haven't been exercising, stop taking Lipitor (atorvastatin) and talk to your doctor right away.
  • Liver damage has been reported in people who take Lipitor (atorvastatin). If you notice dark urine or yellowing of your eyes or skin, talk to your doctor. Your doctor might run blood tests to check your liver.
  • Statins such as Lipitor (atorvastatin) can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, or liver damage. Some people need to stop taking this medicine if these problems occur.
  • Eating grapefruit or drinking grapefruit juice can raise your risk of liver damage while taking Lipitor (atorvastatin).
Pain
CrestorAtorvastatin
  • Call your doctor if you have sudden muscle pain, fever, or weakness.
  • Crestor (rosuvastatin) isn't safe to use if you're pregnant since it can hurt the fetus.
  • Tell your doctor if you suddenly feel severe muscle pain, fever, or weakness.
Upsides and benefits
CrestorAtorvastatin
  • It's a good first choice medicine for lowering cholesterol levels when diet and exercise aren't enough.
  • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as a hardening of the arteries.
  • In clinical studies, Crestor (rosuvastatin) has the strongest effect on lowering "bad" cholesterol compared to other statins.
  • Can lower your risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Available as a generic drug.
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats), and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Lipitor (atorvastatin) can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • It's one of the strongest cholesterol-lowering statin medications.
  • Lipitor (atorvastatin) is a good option for people who have high cholesterol and diabetes.
  • It's available as a generic drug and can be used in combination with other cholesterol lowering drugs.
Downsides and risks
CrestorAtorvastatin
  • You're more likely to have side effects if you're a female, are 65 years or older, drink alcohol every day, or take more than one medicine for cholesterol.
  • People with liver disease, kidney disease, or diabetes are also more likely to have side effects from Crestor (rosuvastatin).
  • Crestor (rosuvastatin) isn't safe to use if you're pregnant since it can hurt the fetus.
  • Statins such as Lipitor (atorvastatin) can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, or liver damage. Some people need to stop taking this medicine if these problems occur.
  • You're at higher risk for these side effects if you are a female, are 65 years or older, or drink more than two alcoholic drinks a day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
  • Eating grapefruit or drinking grapefruit juice can raise your risk of liver damage while taking Lipitor (atorvastatin).
Tips from our pharmacists for people taking the medication
CrestorAtorvastatin
  • Lowers bad cholesterol and triglycerides, and raises good cholesterol levels.
  • Don't have more than 2 glasses of alcohol a day since Crestor (rosuvastatin) can cause liver damage.
  • Don't take antacids for at least 2 hours before and after taking Crestor (rosuvastatin).
  • Call your doctor if you have sudden muscle pain, fever, or weakness.
  • Let your doctor know if you have dark urine or a yellow color in your eyes or skin.
  • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
  • Don't eat grapefruit or drink grapefruit juice while taking this medicine.
  • Tell your doctor if you suddenly feel severe muscle pain, fever, or weakness.
  • Also tell your doctor if you have dark urine or if you notice a yellow tint in your eyes or skin.
  • Lipitor (atorvastatin) isn't safe to use if you're pregnant.
Learn more
More about CrestorSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Crestor (rosuvastatin)?
Worth itNot sureNot worth it
More about AtorvastatinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lipitor (atorvastatin)?
Worth itNot sureNot worth it