Compare Crestor vs. Niaspan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Crestor
(rosuvastatin)

Niaspan
(Niacin)

Lowers cholesterol. Crestor (rosuvastatin) is one of the most effective statins to improve cholesterol. It's also available as a generic.Lowers cholesterol. Niaspan (Niacin) lowers triglycerides, but isn't as good as statins for improving cholesterol levels.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.02Crestor
Reviews for Crestor
60%
of people (All ages) say Crestor is worth it
47%
say it works well
15%
say it's a big hassle
751 reviews
Have you used Crestor (rosuvastatin)?
Worth itNot sureNot worth it
Reviews for Niaspan
43%
+17% better vs. Crestor
31%
+16% better vs. Crestor
19%
+4% better vs. Crestor
380 reviews
Have you used Niaspan (Niacin)?
Worth itNot sureNot worth it
Side effects
CrestorNiaspan
  • Muscle pain 2%
  • Nausea 1%
  • Headache 1%
  • Diabetes mellitus 1%
  • Joint pain 1%
  • Dizziness 1%
More Crestor side effects »
  • Rash 5%
  • Itching 6%
  • Flushing 49%
More Niaspan side effects »
How it works
CrestorNiaspan
Crestor (rosuvastatin) is a statin medication that changes the amount of cholesterol your body makes. It lowers "bad" cholesterol (LDL) and improves your "good" cholesterol (HDL) levels.Niaspan (Niacin) is a cholesterol-lowering medicine. Researchers don't know exactly how it works, but it seems to lower the amount of "bad" cholesterol (LDL) made by the liver.
Type of medication
CrestorNiaspan
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
CrestorNiaspan
  • Pill
  • Pill
  • Extended release
Used for
CrestorNiaspan
Risk factors for serious side effects
CrestorNiaspan
  • Taking Coumadin (warfarin)
  • Age 65 or older
  • Taking higher doses of Crestor (rosuvastatin)
  • Diabetes
  • Heavy alcohol use
Detailed Crestor (rosuvastatin) risks & warnings »
  • Taking Niaspan (Niacin) with statins
  • Heavy alcohol use
  • Past history of liver disease
  • Diabetes
  • Taking Niaspan (Niacin) with anticoagulants
Detailed Niaspan (Niacin) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
CrestorNiaspan
No interactions related info.
  • Niaspan (Niacin) can interact with blood thinners and make you more likely to bleed. Your doctor may have you do regular blood tests and change your medication doses.
Alcohol
CrestorNiaspan
  • Don't have more than 2 glasses of alcohol a day since Crestor (rosuvastatin) can cause liver damage.
  • You're more likely to have side effects if you're a female, are 65 years or older, drink alcohol every day, or take more than one medicine for cholesterol.
  • Don't have alcohol, spicy foods, or hot beverages right before you take this medicine.
Food
CrestorNiaspan
No food related info.
  • You need to take it before bedtime with a low-fat snack.
Kidneys and liver
CrestorNiaspan
  • People on Crestor (rosuvastatin) have reported muscle pain which can lead to muscle or kidney damage. This is more likely to happen if you're older and if you're taking higher doses of Crestor (rosuvastatin). If you suddenly feel severe muscle pain or weakness and you haven't been exercising, stop taking Crestor (rosuvastatin) and talk to your doctor right away.
  • Crestor (rosuvastatin) can cause liver damage. If your urine is darker than normal or if you notice a yellow color in your eyes or skin, talk to your doctor. Your doctor may run some tests to see how your liver is working.
  • People with liver disease, kidney disease, or diabetes are also more likely to have side effects from Crestor (rosuvastatin).
No kidneys and liver related info.
Pain
CrestorNiaspan
  • Call your doctor if you have sudden muscle pain, fever, or weakness.
  • Crestor (rosuvastatin) isn't safe to use if you're pregnant since it can hurt the fetus.
  • It can cause flushing and stomach pain or discomfort.
Upsides and benefits
CrestorNiaspan
  • It's a good first choice medicine for lowering cholesterol levels when diet and exercise aren't enough.
  • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as a hardening of the arteries.
  • In clinical studies, Crestor (rosuvastatin) has the strongest effect on lowering "bad" cholesterol compared to other statins.
  • Can lower your risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Available as a generic drug.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Good for lowering triglycerides (fats).
Downsides and risks
CrestorNiaspan
  • You're more likely to have side effects if you're a female, are 65 years or older, drink alcohol every day, or take more than one medicine for cholesterol.
  • People with liver disease, kidney disease, or diabetes are also more likely to have side effects from Crestor (rosuvastatin).
  • Crestor (rosuvastatin) isn't safe to use if you're pregnant since it can hurt the fetus.
  • By itself, Niaspan (Niacin) isn't as effective as statins for improving cholesterol levels.
  • It can cause flushing and stomach pain or discomfort.
  • You need to take it before bedtime with a low-fat snack.
  • If you miss doses often, you may need to re-start taking the medicine more regularly at a lower dose.
Tips from our pharmacists for people taking the medication
CrestorNiaspan
  • Lowers bad cholesterol and triglycerides, and raises good cholesterol levels.
  • Don't have more than 2 glasses of alcohol a day since Crestor (rosuvastatin) can cause liver damage.
  • Don't take antacids for at least 2 hours before and after taking Crestor (rosuvastatin).
  • Call your doctor if you have sudden muscle pain, fever, or weakness.
  • Let your doctor know if you have dark urine or a yellow color in your eyes or skin.
  • Take Niaspan (Niacin) at bedtime with a low-fat snack.
  • Don't have alcohol, spicy foods, or hot beverages right before you take this medicine.
  • Can cause make your skin feel hot and change color. Your doctor may tell you to take an aspirin 30 minutes before you take Niaspan (Niacin) to reduce the flushing.
  • Call your doctor if you feel unexplained muscle pain.
  • Niaspan (Niacin) works differently from other medicines you can buy over-the-counter. Don't switch it with other medicines unless your doctor agrees.
Learn more
More about CrestorSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Crestor (rosuvastatin)?
Worth itNot sureNot worth it
More about NiaspanSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Niaspan (Niacin)?
Worth itNot sureNot worth it