Compare Crestor vs. simvastatin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Crestor (rosuvastatin)

Prescription only

Zocor (simvastatin)

Prescription only
Lowers cholesterol.

Crestor (rosuvastatin) is one of the most effective statins to improve cholesterol. It's also available as a generic.

5.0/ 7 average rating with 751 reviewsforCrestor
Lowers cholesterol.

Zocor (simvastatin) is a good medication to improve your cholesterol.

5.1/ 7 average rating with 1176 reviewsforsimvastatin
Upsides
  • It's a good first choice medicine for lowering cholesterol levels when diet and exercise aren't enough.
  • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as a hardening of the arteries.
  • In clinical studies, Crestor (rosuvastatin) has the strongest effect on lowering "bad" cholesterol compared to other statins.
  • Can lower your risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Available as a generic drug.
  • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Available in generic.
  • Available in combination pills with other cholesterol medicines.
Downsides
  • You're more likely to have side effects if you're a female, are 65 years or older, drink alcohol every day, or take more than one medicine for cholesterol.
  • People with liver disease, kidney disease, or diabetes are also more likely to have side effects from Crestor (rosuvastatin).
  • Crestor (rosuvastatin) isn't safe to use if you're pregnant since it can hurt the fetus.
  • You are at higher risk for side effects if you are female, are 65 years or older, drink alcohol every day, or have liver disease, kidney disease, or diabetes.
  • Not safe to use if you're pregnant.
  • Can have more drug interactions than some other drugs in the same class (statins).
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$14.45
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$4
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Reviews
751 
60%
think this treatment is worth it
47%
think this treatment works well
15%
think this treatment is a hassle

Have you used Crestor (rosuvastatin)?

Leave a review
1176 
61%
think this treatment is worth it
48%
think this treatment works well
14%
think this treatment is a hassle

Have you used Zocor (simvastatin)?

Leave a review
Side effects
The Crestor (rosuvastatin) FDA package insert doesn’t have numbers about how common side effects are.
The Zocor (simvastatin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Elevated INR

    Taking Coumadin (warfarin)

  • Muscle pain

    Age 65 or older

    ...and 1 more risk factors

  • Increased blood sugars

    Diabetes

  • Liver damage

    Heavy alcohol use

    ...and 1 more risk factors

  • Birth defects

    Pregnancy

See more detailed risks and warnings
  • Muscle pain and kidney damage

    Kidney disease

    ...and 4 more risk factors

  • Liver damage

    Heavy alcohol use

    ...and 1 more risk factors

  • Harm to unborn baby

    Pregnancy

    ...and 1 more risk factors

  • Drug interactions

    Certain drugs can increase the dose of Zocor (simvastatin) in the body

  • High blood sugar

    History of high blood sugar

See more detailed risks and warnings