Compare Crestor vs. Simvastatin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Crestor
(rosuvastatin)

Zocor
(simvastatin)

Lowers cholesterol. Crestor (rosuvastatin) is one of the most effective statins to improve cholesterol. It's also available as a generic.Lowers cholesterol. Zocor (Simvastatin) is a good medication to improve your cholesterol. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.
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Prices and coupon for 30 (10mg) tablets of rosuvastatin
Coupons for
Prices and coupon for 30 (20mg) tablets of simvastatin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.02Crestor
Reviews for Crestor (rosuvastatin)
60%
of people (All ages) say Crestor (rosuvastatin) is worth it
47%
say it works well
15%
say it's a big hassle
751 reviews
Have you used Crestor (rosuvastatin)?
Worth itNot sureNot worth it
Reviews for Zocor (simvastatin)
61%
+1% better vs. Crestor (rosuvastatin)
48%
+1% better vs. Crestor (rosuvastatin)
14%
+1% better vs. Crestor (rosuvastatin)
1176 reviews
Have you used Zocor (simvastatin)?
Worth itNot sureNot worth it
Side effects
CrestorSimvastatin
  • Headache 1%
  • Nausea 1%
  • Muscle pain 2%
  • Joint pain 1%
  • Diabetes mellitus 1%
  • Dizziness 1%
More Crestor side effects »
  • Upper respiratory infections 9%
  • Abdominal pain 7%
  • Constipation 7%
  • Headache 7%
  • Bronchitis 1%
  • Abnormal heart rhythm 1%
  • Nausea 5%
  • Scaly, itchy rash 2%
  • Upset stomach 3%
  • Vertigo 1%
More Simvastatin side effects »
How it works
CrestorSimvastatin
Crestor (rosuvastatin) is a statin medication that changes the amount of cholesterol your body makes. It lowers "bad" cholesterol (LDL) and improves your "good" cholesterol (HDL) levels.Zocor (Simvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).
Type of medication
CrestorSimvastatin
Prescription only
Prescription only
Available as
CrestorSimvastatin
  • Pill
  • Pill
  • Dissolving tablet
Used for
CrestorSimvastatin
Risk factors for serious side effects
CrestorSimvastatin
  • Taking Coumadin (warfarin)
  • Age 65 or older
  • Taking higher doses of Crestor (rosuvastatin)
  • Diabetes
  • Heavy alcohol use
  • Prior history of chronic liver disease
  • Pregnancy
Detailed Crestor (rosuvastatin) risks & warnings »
  • Kidney disease
  • High dose of Zocor (Simvastatin)
  • Combining Zocor (Simvastatin) with certain cholesterol-lowering drugs
  • Older age and female gender
  • Heavy alcohol use
  • History of chronic liver disease
  • Pregnancy
  • Breast feeding
  • Certain drugs can increase the dose of Zocor (Simvastatin) in the body
    Detailed Zocor (simvastatin) risks & warnings »
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Interactions
    CrestorSimvastatin
    No interactions related info.
    • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
    Alcohol
    CrestorSimvastatin
    • You're more likely to have side effects if you're a female, are 65 years or older, drink alcohol every day, or take more than one medicine for cholesterol.
    • Don't have more than 2 glasses of alcohol a day since Crestor (rosuvastatin) can cause liver damage.
    • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
    Kidneys and liver
    CrestorSimvastatin
    • People with liver disease, kidney disease, or diabetes are also more likely to have side effects from Crestor (rosuvastatin).
    • People on Crestor (rosuvastatin) have reported muscle pain which can lead to muscle or kidney damage. This is more likely to happen if you're older and if you're taking higher doses of Crestor (rosuvastatin). If you suddenly feel severe muscle pain or weakness and you haven't been exercising, stop taking Crestor (rosuvastatin) and talk to your doctor right away.
    • Crestor (rosuvastatin) can cause liver damage. If your urine is darker than normal or if you notice a yellow color in your eyes or skin, talk to your doctor. Your doctor may run some tests to see how your liver is working.
    • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
    • There are rare cases of muscle damage leading to kidney failure in people taking Zocor (Simvastatin). The risk is greater in people with kidney disease or thyroid disease, are older and female and taking certain cholesterol-lowering medication combinations. Tell your doctor if you develop sudden muscle pain, weakness or fever and there is no known cause.
    • There are reports of liver damage in people who take Zocor (Simvastatin), especially if they are heavy alcohol drinkers or have a history of liver disease. If you notice dark urine or yellowing of the eyes or skin, tell your doctor. Your doctor may also want to check your liver function periodically.
    Pain
    CrestorSimvastatin
    • Crestor (rosuvastatin) isn't safe to use if you're pregnant since it can hurt the fetus.
    • Call your doctor if you have sudden muscle pain, fever, or weakness.
    • Combining certain medications can increase the risk of muscle pain (myopathy), muscle damage (rhabdomyolysis) and kidney damage. Talk to your doctor or pharmacist when taking any new medications.
    Upsides and benefits
    CrestorSimvastatin
    • It's a good first choice medicine for lowering cholesterol levels when diet and exercise aren't enough.
    • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as a hardening of the arteries.
    • In clinical studies, Crestor (rosuvastatin) has the strongest effect on lowering "bad" cholesterol compared to other statins.
    • Can lower your risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
    • Available as a generic drug.
    • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
    • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
    Downsides and risks
    CrestorSimvastatin
    • You're more likely to have side effects if you're a female, are 65 years or older, drink alcohol every day, or take more than one medicine for cholesterol.
    • People with liver disease, kidney disease, or diabetes are also more likely to have side effects from Crestor (rosuvastatin).
    • Crestor (rosuvastatin) isn't safe to use if you're pregnant since it can hurt the fetus.
    • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
    • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
    • Not safe to use if you're pregnant.
    Tips from our pharmacists for people taking the medication
    CrestorSimvastatin
    • Lowers bad cholesterol and triglycerides, and raises good cholesterol levels.
    • Don't have more than 2 glasses of alcohol a day since Crestor (rosuvastatin) can cause liver damage.
    • Don't take antacids for at least 2 hours before and after taking Crestor (rosuvastatin).
    • Call your doctor if you have sudden muscle pain, fever, or weakness.
    • Let your doctor know if you have dark urine or a yellow color in your eyes or skin.
    • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
    • Most people reach their target cholesterol levels in 4 to 6 weeks.
    • Avoid grapefruit and grapefruit juice while taking this medicine.
    • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
    • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
    • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
    Learn more
    More about CrestorSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Crestor (rosuvastatin)?
    Worth itNot sureNot worth it
    More about SimvastatinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zocor (simvastatin)?
    Worth itNot sureNot worth it