Compare Crestor vs. Simvastatin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Crestor
(Rosuvastatin)

Zocor
(Simvastatin)

Lowers cholesterol. Crestor (Rosuvastatin) is one of the most effective statins to improve cholesterol, but the brand name medication is expensive. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.Lowers cholesterol. Zocor (Simvastatin) is a good medication to improve your cholesterol. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.017333333333333Crestor
Reviews for Crestor (Rosuvastatin)
61%
of people say Crestor (Rosuvastatin) is worth it
47%
say it works well
15%
say it's a big hassle
Reviews for Zocor (Simvastatin)
61%
Same vs. Crestor (Rosuvastatin)
48%
+1% vs. Crestor (Rosuvastatin)
14%
+1% vs. Crestor (Rosuvastatin)
Side effects
CrestorSimvastatin
  • Headache 4%
  • Constipation 3%
  • Joint pain 3%
  • Nausea 3%
  • Muscle weakness 2%
  • Muscle pain 1%
  • Dizziness 1%
  • Diabetes mellitus 1%
More Crestor side effects »
  • Upset stomach 3%
  • Scaly, itchy rash 2%
  • Bronchitis 1%
  • Vertigo 1%
  • Muscle pain 1%
  • Edema/swelling 1%
  • Abnormal heart rhythm 1%
More Simvastatin side effects »
How it works
CrestorSimvastatin
Crestor (Rosuvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).Zocor (Simvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).
Type of medication
CrestorSimvastatin
Cholesterol-lowering
Statin
Prescription only
Cholesterol-lowering
Statin
Prescription only
Available as
CrestorSimvastatin
  • Pill
  • Pill
  • Dissolving tablet
Used for (click to learn more)
CrestorSimvastatin
Risk factors for serious side effects
CrestorSimvastatin
    • Heavy alcohol use
    • Prior history of chronic liver disease
    • Pregnancy
    Detailed Crestor (Rosuvastatin) risks & warnings »
    • Kidney disease
    • High dose of Zocor (Simvastatin)
    • Combining Zocor (Simvastatin) with certain cholesterol-lowering drugs
    • Older age and female gender
    • Heavy alcohol use
    • History of chronic liver disease
    • Pregnancy
    • Breast feeding
    • Certain drugs can increase the dose of Zocor (Simvastatin) in the body
      Detailed Zocor (Simvastatin) risks & warnings »
      Pregnancy category
      CrestorSimvastatin
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      Alcohol
      • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
      • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
      • There are reports of liver damage in people who take Zocor (Simvastatin), especially if they are heavy alcohol drinkers or have a history of liver disease. If you notice dark urine or yellowing of the eyes or skin, tell your doctor. Your doctor may also want to check your liver function periodically.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
      • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
      • People on Crestor (Rosuvastatin) have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
      • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
      • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
      • There are rare cases of muscle damage leading to kidney failure in people taking Zocor (Simvastatin). The risk is greater in people with kidney disease or thyroid disease, are older and female and taking certain cholesterol-lowering medication combinations. Tell your doctor if you develop sudden muscle pain, weakness or fever and there is no known cause.
      • Combining certain medications can increase the risk of muscle pain (myopathy), muscle damage (rhabdomyolysis) and kidney damage. Talk to your doctor or pharmacist when taking any new medications.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      CrestorSimvastatin
      • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as hardening of the arteries.
      • In clinical studies, Crestor has the strongest effect on lowering "bad" cholesterol compared to other statins.
      • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
      • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
      • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
      • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
      Downsides and risks
      CrestorSimvastatin
      • Even with a generic available in 2016, can be expensive.
      • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
      • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
      • Not safe to use if you're pregnant.
      • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
      • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
      • Not safe to use if you're pregnant.
      Tips from our pharmacists for people taking the medication
      CrestorSimvastatin
      • Don't take antacids for at least 2 hours before and after taking this medicine.
      • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
      • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
      • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
      • Most people reach their target cholesterol levels in 4 to 6 weeks.
      • Avoid grapefruit and grapefruit juice while taking this medicine.
      • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
      • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
      • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
      • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
      Learn more
      More about CrestorSide effectsReviews & ratingsAlternativesFDA package insert
      More about SimvastatinSide effectsReviews & ratingsAlternativesFDA package insert