Compare Crestor vs. Trilipix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Crestor
(rosuvastatin)

Trilipix
(fenofibric acid)

Lowers cholesterol. Crestor (rosuvastatin) is one of the most effective statins to improve cholesterol. It's also available as a generic.Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.02Crestor
Reviews for Crestor
60%
of people (All ages) say Crestor is worth it
47%
say it works well
15%
say it's a big hassle
751 reviews
Have you used Crestor (rosuvastatin)?
Worth itNot sureNot worth it
Reviews for Trilipix
50%
+10% better vs. Crestor
22%
+25% better vs. Crestor
25%
+10% better vs. Crestor
Have you used Trilipix (fenofibric acid)?
Worth itNot sureNot worth it
Side effects
CrestorTrilipix
  • Headache 1%
  • Nausea 1%
  • Muscle pain 2%
  • Joint pain 1%
  • Diabetes mellitus 1%
  • Dizziness 1%
More Crestor side effects »
  • Headache 13%
  • Back Pain 6%
  • Pain in Extremity 5%
  • Upper respiratory tract infection 5%
  • Nausea 4%
  • Nasopharyngitis 4%
  • Diarrhea 4%
  • Arthralgia 4%
  • Pain 4%
  • Dizziness 4%
More Trilipix side effects »
How it works
CrestorTrilipix
Crestor (rosuvastatin) is a statin medication that changes the amount of cholesterol your body makes. It lowers "bad" cholesterol (LDL) and improves your "good" cholesterol (HDL) levels.Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).
Type of medication
CrestorTrilipix
Prescription onlyPrescription only
Available as
CrestorTrilipix
  • Pill
  • Pill
  • Extended release
Used for
CrestorTrilipix
Risk factors for serious side effects
CrestorTrilipix
  • Taking Coumadin (warfarin)
  • Age 65 or older
  • Taking higher doses of Crestor (rosuvastatin)
  • Diabetes
  • Heavy alcohol use
Detailed Crestor (rosuvastatin) risks & warnings »
  • Taking Trilipix (Fenofibric Acid) with statins
  • Past history of liver disease
  • Taking Trilipix (Fenofibric Acid) with anticoagulants
Detailed Trilipix (fenofibric acid) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
CrestorTrilipix
  • Don't have more than 2 glasses of alcohol a day since Crestor (rosuvastatin) can cause liver damage.
  • You're more likely to have side effects if you're a female, are 65 years or older, drink alcohol every day, or take more than one medicine for cholesterol.
No alcohol related info.
Kidneys and liver
CrestorTrilipix
  • People on Crestor (rosuvastatin) have reported muscle pain which can lead to muscle or kidney damage. This is more likely to happen if you're older and if you're taking higher doses of Crestor (rosuvastatin). If you suddenly feel severe muscle pain or weakness and you haven't been exercising, stop taking Crestor (rosuvastatin) and talk to your doctor right away.
  • Crestor (rosuvastatin) can cause liver damage. If your urine is darker than normal or if you notice a yellow color in your eyes or skin, talk to your doctor. Your doctor may run some tests to see how your liver is working.
  • People with liver disease, kidney disease, or diabetes are also more likely to have side effects from Crestor (rosuvastatin).
  • Reports of liver damage have been reported in people who take Trilipix (Fenofibric Acid), especially in people with a history of liver disease. Your doctor may monitor your liver with blood tests on a regular basis.
Pain
CrestorTrilipix
  • Call your doctor if you have sudden muscle pain, fever, or weakness.
  • Crestor (rosuvastatin) isn't safe to use if you're pregnant since it can hurt the fetus.
No pain related info.
Upsides and benefits
CrestorTrilipix
  • It's a good first choice medicine for lowering cholesterol levels when diet and exercise aren't enough.
  • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as a hardening of the arteries.
  • In clinical studies, Crestor (rosuvastatin) has the strongest effect on lowering "bad" cholesterol compared to other statins.
  • Can lower your risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Available as a generic drug.
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Good medicine for lowering triglycerides.
Downsides and risks
CrestorTrilipix
  • You're more likely to have side effects if you're a female, are 65 years or older, drink alcohol every day, or take more than one medicine for cholesterol.
  • People with liver disease, kidney disease, or diabetes are also more likely to have side effects from Crestor (rosuvastatin).
  • Crestor (rosuvastatin) isn't safe to use if you're pregnant since it can hurt the fetus.
  • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
  • Different forms and strengths of this medication can't be substituted for each other.
Tips from our pharmacists for people taking the medication
CrestorTrilipix
  • Lowers bad cholesterol and triglycerides, and raises good cholesterol levels.
  • Don't have more than 2 glasses of alcohol a day since Crestor (rosuvastatin) can cause liver damage.
  • Don't take antacids for at least 2 hours before and after taking Crestor (rosuvastatin).
  • Call your doctor if you have sudden muscle pain, fever, or weakness.
  • Let your doctor know if you have dark urine or a yellow color in your eyes or skin.
  • Can be used with other medications to help lower cholesterol.
  • Lowers triglycerides.
  • Can raise your chance of getting colds and flu.
  • Call your doctor if you develop muscle or abdominal pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
Learn more
More about CrestorSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Crestor (rosuvastatin)?
Worth itNot sureNot worth it
More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Trilipix (fenofibric acid)?
Worth itNot sureNot worth it