Compare Crestor vs. Trilipix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Crestor
(Rosuvastatin)

Trilipix
(Fenofibric Acid)

Lowers cholesterol. Crestor (Rosuvastatin) is one of the most effective statins to improve cholesterol, but the brand name medication is expensive. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.
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Reviews & ratings
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Button Group. All currently active
5.017333333333333Crestor
Reviews for Crestor (Rosuvastatin)
61%
of people say Crestor (Rosuvastatin) is worth it
47%
say it works well
15%
say it's a big hassle
Reviews for Trilipix (Fenofibric Acid)
49%
12% vs. Crestor (Rosuvastatin)
22%
25% vs. Crestor (Rosuvastatin)
25%
10% vs. Crestor (Rosuvastatin)
Side effects
CrestorTrilipix
  • Headache 4%
  • Constipation 3%
  • Joint pain 3%
  • Nausea 3%
  • Muscle weakness 2%
  • Muscle pain 1%
  • Dizziness 1%
  • Diabetes mellitus 1%
More Crestor side effects »
  • Abnormal liver tests 7%
  • Increased creatine phosphokinase 2%
  • Abdominal pain 1%
  • Inflammation inside the nose 1%
  • Decreased liver function 1%
More Trilipix side effects »
How it works
CrestorTrilipix
Crestor (Rosuvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).
Type of medication
CrestorTrilipix
Cholesterol-lowering
Statin
Prescription only
Cholesterol-lowering
Fibric acid
Prescription only
Available as
CrestorTrilipix
  • Pill
  • Pill
  • Extended release
Used for (click to learn more)
CrestorTrilipix
Risk factors for serious side effects
CrestorTrilipix
    • Heavy alcohol use
    • Prior history of chronic liver disease
    • Pregnancy
    Detailed Crestor (Rosuvastatin) risks & warnings »
    • Taking Trilipix (Fenofibric Acid) with statins
    • Past history of liver disease
      • Taking Trilipix (Fenofibric Acid) with anticoagulants
                Detailed Trilipix (Fenofibric Acid) risks & warnings »
                Pregnancy category
                CrestorTrilipix
                XFDA pregnancy category (Unsafe)

                Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

                See the FDA package insert
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                Alcohol
                • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
                No specific alcohol-related info.
                Food
                No specific food-related info.No specific food-related info.
                Kidneys and liver
                • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
                • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
                • People on Crestor (Rosuvastatin) have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
                • People on Trilipix (Fenofibric Acid) while taking statins have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
                Sex
                No specific sex-related info.No specific sex-related info.
                Sleep
                No specific sleep-related info.No specific sleep-related info.
                Weight
                No specific weight-related info.No specific weight-related info.
                Upsides and benefits
                CrestorTrilipix
                • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as hardening of the arteries.
                • In clinical studies, Crestor has the strongest effect on lowering "bad" cholesterol compared to other statins.
                • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
                • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                • Good medicine for lowering triglycerides.
                • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                Downsides and risks
                CrestorTrilipix
                • Even with a generic available in 2016, can be expensive.
                • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
                • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
                • Not safe to use if you're pregnant.
                • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
                • Different forms and strengths of this medication can't be substituted for each other.
                Tips from our pharmacists for people taking the medication
                CrestorTrilipix
                • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
                • Don't take antacids for at least 2 hours before and after taking this medicine.
                • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
                • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
                • Can be used with other medications to help lower cholesterol.
                • Lowers triglycerides.
                • Can raise your chance of getting colds and flu.
                • Call your doctor if you develop muscle or abdominal pain.
                • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
                Learn more
                More about CrestorSide effectsReviews & ratingsAlternativesFDA package insert
                More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert