Compare Crestor vs. Vytorin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Crestor
(Rosuvastatin)

Vytorin
(Ezetimibe / Simvastatin)

Lowers cholesterol. Crestor (Rosuvastatin) is one of the most effective statins to improve cholesterol, but the brand name medication is expensive. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.017333333333333Crestor
Reviews for Crestor (Rosuvastatin)
61%
of people say Crestor (Rosuvastatin) is worth it
47%
say it works well
15%
say it's a big hassle
Reviews for Vytorin (Ezetimibe / Simvastatin)
52%
9% vs. Crestor (Rosuvastatin)
36%
11% vs. Crestor (Rosuvastatin)
19%
4% vs. Crestor (Rosuvastatin)
Side effects
CrestorVytorin
  • Headache 4%
  • Constipation 3%
  • Joint pain 3%
  • Nausea 3%
  • Muscle weakness 2%
  • Muscle pain 1%
  • Dizziness 1%
  • Diabetes mellitus 1%
More Crestor side effects »
  • Unexplained muscle pain or weakness 1%
  • Ear, nose, or throat infection 1%
  • Pain in extremity 1%
  • Flu 1%
More Vytorin side effects »
How it works
CrestorVytorin
Crestor (Rosuvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.
Type of medication
CrestorVytorin
Cholesterol-lowering
Statin
Prescription only
Cholesterol-lowering
Cholesterol inhibitor
Statin
Prescription only
Available as
CrestorVytorin
  • Pill
  • Pill
Used for (click to learn more)
CrestorVytorin
Risk factors for serious side effects
CrestorVytorin
    • Heavy alcohol use
    • Prior history of chronic liver disease
    • Pregnancy
    Detailed Crestor (Rosuvastatin) risks & warnings »
    • Asian patients taking high-dose niacin
    • Past history of liver disease
    • heavy alcohol use
    • Diabetes
        • Pregnancy
        Detailed Vytorin (Ezetimibe / Simvastatin) risks & warnings »
        Pregnancy category
        CrestorVytorin
        XFDA pregnancy category (Unsafe)

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        See the FDA package insert
        XFDA pregnancy category (Unsafe)

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        See the FDA package insert
        Alcohol
        • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
        • People who take Vytorin (Ezetimibe / Simvastatin) have reported liver damage, especially if taken with statins or if you drink large amounts of alcohol. This has been rare. Talk to your doctor if you've ever had liver disease as they may discuss alternatives, or they may monitor your liver with blood tests.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
        • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
        • People on Crestor (Rosuvastatin) have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
        • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        CrestorVytorin
        • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
        • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as hardening of the arteries.
        • In clinical studies, Crestor has the strongest effect on lowering "bad" cholesterol compared to other statins.
        • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
        • A 2-in-1 cholesterol-lowering combination medicine.
        • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
        Downsides and risks
        CrestorVytorin
        • Even with a generic available in 2016, can be expensive.
        • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
        • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
        • Not safe to use if you're pregnant.
        • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
        • There's no generic available, so it can be expensive.
        Tips from our pharmacists for people taking the medication
        CrestorVytorin
        • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
        • Don't take antacids for at least 2 hours before and after taking this medicine.
        • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
        • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
        • Take it in the evening.
        • Avoid grapefruit and grapefruit juice while taking this medicine.
        • Can cause headaches or diarrhea.
        • Call your doctor if you develop muscle pain.
        • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
        Learn more
        More about CrestorSide effectsReviews & ratingsAlternativesFDA package insert
        More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert