Compare Crestor vs. Zetia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Crestor
(Rosuvastatin)

Zetia
(Ezetimibe)

Lowers cholesterol. Crestor (Rosuvastatin) is one of the most effective statins to improve cholesterol, but the brand name medication is expensive. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.Lowers cholesterol. Zetia can improve your cholesterol, but it doesn't reduce heart attacks or heart disease, and it's expensive compared to other cholesterol-lowering medicines.
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Reviews & ratings
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5.017333333333333Crestor
Reviews for Crestor (Rosuvastatin)
61%
of people say Crestor (Rosuvastatin) is worth it
47%
say it works well
15%
say it's a big hassle
Reviews for Zetia (Ezetimibe)
42%
19% vs. Crestor (Rosuvastatin)
34%
13% vs. Crestor (Rosuvastatin)
20%
5% vs. Crestor (Rosuvastatin)
Side effects
CrestorZetia
  • Headache 4%
  • Constipation 3%
  • Joint pain 3%
  • Nausea 3%
  • Muscle weakness 2%
  • Muscle pain 1%
  • Dizziness 1%
  • Diabetes mellitus 1%
More Crestor side effects »
  • Ear, nose, or throat infection 1%
  • Sinus inflammation 1%
  • Arthtralgia 1%
More Zetia side effects »
How it works
CrestorZetia
Crestor (Rosuvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).Zetia is a cholesterol-lowering medicine. It prevents cholesterol absorption in your intestines, lowers the amount of cholesterol stored in your liver, and helps your body process cholesterol.
Type of medication
CrestorZetia
Cholesterol-lowering
Statin
Prescription only
Cholesterol-lowering
Cholesterol inhibitor
Prescription only
Available as
CrestorZetia
  • Pill
  • Pill
Used for (click to learn more)
CrestorZetia
Risk factors for serious side effects
CrestorZetia
    • Heavy alcohol use
    • Prior history of chronic liver disease
    • Pregnancy
    Detailed Crestor (Rosuvastatin) risks & warnings »
      • Taking Zetia (Ezetimibe) with statins
      • Past history of liver disease
      • Taking Zetia (Ezetimibe) with statins
      Detailed Zetia (Ezetimibe) risks & warnings »
      Pregnancy category
      CrestorZetia
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
      No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
      • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
      • People on Crestor (Rosuvastatin) have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
      • People on Zetia (Ezetimibe) while taking statins have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      CrestorZetia
      • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
      • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as hardening of the arteries.
      • In clinical studies, Crestor has the strongest effect on lowering "bad" cholesterol compared to other statins.
      • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
      • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
      • Can be used with other medicines to improve cholesterol.
      • Available in a combination pill with simvastatin.
      Downsides and risks
      CrestorZetia
      • Even with a generic available in 2016, can be expensive.
      • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
      • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
      • Not safe to use if you're pregnant.
      • Doesn't lower triglycerides (fats).
      • Hasn't been shown to lower the risk of heart attacks or heart disease.
      • By itself, Zetia is not as effective as statins for improving cholesterol.
      • There's no generic available, so it can be expensive.
      Tips from our pharmacists for people taking the medication
      CrestorZetia
      • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
      • Don't take antacids for at least 2 hours before and after taking this medicine.
      • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
      • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
      • Lowers bad cholesterol, and raises good cholesterol.
      • Tell your doctor if you develop bone or muscle pain.
      • Can be used with other medications to lower cholesterol.
      • May cause diarrhea or raise your chance of getting colds.
      Learn more
      More about CrestorSide effectsReviews & ratingsAlternativesFDA package insert
      More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert