Compare Crestor vs. Zetia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Crestor
(rosuvastatin)

Zetia
(ezetimibe)

Lowers cholesterol. Crestor (rosuvastatin) is one of the most effective statins to improve cholesterol. It's also available as a generic.Lowers cholesterol. Zetia (ezetimibe) can improve your cholesterol and can be used as an alternative to statins.
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Prices and coupon for 30 (10mg) tablets of rosuvastatin
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Prices and coupon for 30 (10mg) tablets of ezetimibe
Reviews & ratings
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5.02Crestor
Reviews for Crestor (rosuvastatin)
60%
of people (All ages) say Crestor (rosuvastatin) is worth it
47%
say it works well
15%
say it's a big hassle
751 reviews
Have you used Crestor (rosuvastatin)?
Worth itNot sureNot worth it
Reviews for Zetia (ezetimibe)
42%
-18% worse vs. Crestor (rosuvastatin)
34%
-13% worse vs. Crestor (rosuvastatin)
21%
-6% worse vs. Crestor (rosuvastatin)
128 reviews
Have you used Zetia (ezetimibe)?
Worth itNot sureNot worth it
Side effects
CrestorZetia
  • Headache 1%
  • Nausea 1%
  • Muscle pain 2%
  • Joint pain 1%
  • Diabetes mellitus 1%
  • Dizziness 1%
More Crestor side effects »
  • Common cold 1%
  • Sore throat 4%
  • Sinus infection 1%
  • Abnormal liver tests 3%
  • Joint pain 1%
  • Pain in arms and legs 1%
  • Muscle pain 3%
More Zetia side effects »
How it works
CrestorZetia
Crestor (rosuvastatin) is a statin medication that changes the amount of cholesterol your body makes. It lowers "bad" cholesterol (LDL) and improves your "good" cholesterol (HDL) levels.Zetia (ezetimibe) is a cholesterol-lowering medicine. It stops your body from absorbing cholesterol in food and helps process other forms of cholesterol.
Type of medication
CrestorZetia
Prescription only
Prescription only
Available as
CrestorZetia
  • Pill
  • Pill
Used for
CrestorZetia
Risk factors for serious side effects
CrestorZetia
  • Taking Coumadin (warfarin)
  • Age 65 or older
  • Taking higher doses of Crestor (rosuvastatin)
  • Diabetes
  • Heavy alcohol use
  • Prior history of chronic liver disease
  • Pregnancy
Detailed Crestor (rosuvastatin) risks & warnings »
    • Taking Zetia (ezetimibe) with statins
    • Past history of liver disease
    • Taking Zetia (ezetimibe) with statins
    Detailed Zetia (ezetimibe) risks & warnings »
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    CrestorZetia
    • You're more likely to have side effects if you're a female, are 65 years or older, drink alcohol every day, or take more than one medicine for cholesterol.
    • Don't have more than 2 glasses of alcohol a day since Crestor (rosuvastatin) can cause liver damage.
    No alcohol related info.
    Kidneys and liver
    CrestorZetia
    • People with liver disease, kidney disease, or diabetes are also more likely to have side effects from Crestor (rosuvastatin).
    • People on Crestor (rosuvastatin) have reported muscle pain which can lead to muscle or kidney damage. This is more likely to happen if you're older and if you're taking higher doses of Crestor (rosuvastatin). If you suddenly feel severe muscle pain or weakness and you haven't been exercising, stop taking Crestor (rosuvastatin) and talk to your doctor right away.
    • Crestor (rosuvastatin) can cause liver damage. If your urine is darker than normal or if you notice a yellow color in your eyes or skin, talk to your doctor. Your doctor may run some tests to see how your liver is working.
    • Zetia (ezetimibe) can hurt your liver, especially if it is used with statins. Talk to your doctor if you have liver disease.
    Pain
    CrestorZetia
    • Crestor (rosuvastatin) isn't safe to use if you're pregnant since it can hurt the fetus.
    • Call your doctor if you have sudden muscle pain, fever, or weakness.
    • Zetia (ezetimibe) can hurt your liver, especially if it is used with statins. Talk to your doctor if you have liver disease.
    Upsides and benefits
    CrestorZetia
    • It's a good first choice medicine for lowering cholesterol levels when diet and exercise aren't enough.
    • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as a hardening of the arteries.
    • In clinical studies, Crestor (rosuvastatin) has the strongest effect on lowering "bad" cholesterol compared to other statins.
    • Can lower your risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
    • Available as a generic drug.
    • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
    • Can be used with other medicines to improve cholesterol.
    • Available in a combination pill with simvastatin.
    • Available as a generic.
    Downsides and risks
    CrestorZetia
    • You're more likely to have side effects if you're a female, are 65 years or older, drink alcohol every day, or take more than one medicine for cholesterol.
    • People with liver disease, kidney disease, or diabetes are also more likely to have side effects from Crestor (rosuvastatin).
    • Crestor (rosuvastatin) isn't safe to use if you're pregnant since it can hurt the fetus.
    • Doesn't lower triglycerides (fats).
    • Hasn't been shown to lower the risk of heart attacks or heart disease.
    • By itself, it isn't as effective as statins for improving cholesterol.
    Tips from our pharmacists for people taking the medication
    CrestorZetia
    • Lowers bad cholesterol and triglycerides, and raises good cholesterol levels.
    • Don't have more than 2 glasses of alcohol a day since Crestor (rosuvastatin) can cause liver damage.
    • Don't take antacids for at least 2 hours before and after taking Crestor (rosuvastatin).
    • Call your doctor if you have sudden muscle pain, fever, or weakness.
    • Let your doctor know if you have dark urine or a yellow color in your eyes or skin.
    • Lowers bad cholesterol and raises good cholesterol.
    • Tell your doctor if you develop bone or muscle pain.
    • Can be used with other medications to lower cholesterol.
    • Good alternative to statins if you can't tolerate statins or are unable to control cholesterol with statins alone.
    • Can cause diarrhea or increase your chance of getting colds.
    Learn more
    More about CrestorSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Crestor (rosuvastatin)?
    Worth itNot sureNot worth it
    More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zetia (ezetimibe)?
    Worth itNot sureNot worth it