Compare cromolyn vs. Humira

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves nasal allergy symptoms. Intal (Cromolyn) is a good option to relieve nasal allergy symptoms when antihistamines aren't working. Good choice for pregnant women.Calms down your immune system. Humira (Adalimumab) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.
How it works
Intal (Cromolyn) is a mast-cell stabilizer nasal spray that prevents and treats seasonal allergies.Humira (Adalimumab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.
Type of medication
Mast cell stabilizerPrescription or OTC
Biological response modifier
Prescription only
Available as
  • Nasal spray
  • Injection
Used for (click to learn more)
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Reviews & ratings
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Reviews for Humira (Adalimumab)
+59% vs. Intal (Cromolyn)
+49% vs. Intal (Cromolyn)
26% vs. Intal (Cromolyn)
Side effects

We haven’t found good data for cromolyn side effects.

FDA side effect reports for cromolyn »
  • Injection site reactions 6%
  • Rash 6%
  • Positive titers 5%
  • Upper respiratory infection 4%
  • Headache 4%
  • Abdominal pain 3%
  • Urinary tract infection 3%
  • High blood pressure 2%
  • Alkaline phosphatase increased 2%
  • High blood lipid levels 2%
More Humira side effects »
Risk factors for serious side effects
Coming soon.
    • History of heart failure
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • Taking other immunosuppressant drugs
    • History of malignancy
    • History of neurologic condition
      Detailed Humira (Adalimumab) risks & warnings »
      Pregnancy category
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      No specific alcohol-related info.No specific alcohol-related info.
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      No specific sex-related info.No specific sex-related info.
      No specific sleep-related info.No specific sleep-related info.
      No specific weight-related info.
      • Humira (Adalimumab) can increase your risk of serious or life-threatening bacterial, fungal and viral infections. In some cases infections can be reactivated from an inactive virus in your body like tuberculosis (TB) or hepatitis B virus (HBV). You may need to take medicine for TB before you can begin taking Humira (Adalimumab). If you develop symptoms of cough, fever, chills, muscle aches, feel very tired, or you notice dark urine, yellowing of skin/eyes, appetite/weight loss, vomiting, change in stool color, stomach discomfort, and skin rash, tell your doctor and get medical care right away.
      Upsides and benefits
      • Treats nasal allergy symptoms.
      • Most people don't have many side effects since it works in the nose and doesn't affect the rest of your body.
      • It's a good option for pregnant women. Can also be used for kids 2 years and older.
      • Doesn't make you drowsy or dizzy.
      • No prescription is needed.
      • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
      • Most people feel it's worth the hassle.
      • Once you've learned the correct way to use Humira, you can inject the medicine yourself without going to your doctor's office.
      • It's available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
      • It's an alternative for people with Crohn's disease who stopped getting better on other TNF-blockers or had side effects that made them switch.
      Downsides and risks
      • Needs to be used regularly for at least a week to see any good effects.
      • Can have an unpleasant smell or taste.
      • Can cause headaches, or burning and stinging in your nose.
      • It's an injection.
      • It's expensive because there's no generic available yet.
      • Humira lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
      • You're first dose of Humira will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
      • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
      • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
      Tips from our pharmacists for people taking the medication
      • Works best when used one week before exposure to allergens. It takes about 1 to 2 weeks until you feel the full effects.
      • Check with your doctor or pharmacist to make sure you know how to use this nose spray. Don't use more than recommended.
      • Shake the spray gently and clear your nose before each use.
      • Before using it for the first time, prime the spray pump until you see a fine mist.
      • Breathe in slowly as you're spraying. Wait a few minutes before blowing your nose if needed.
      • Humira (Adalimumab) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
      • Humira (Adalimumab) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
      • You'll need to have a TB test before you start using Humira (Adalimumab).
      • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
      • Don't inject Humira (Adalimumab) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
      • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
      Learn more
      More about cromolynSide effectsAlternativesFDA package insert
      More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert