Compare cyclophosphamide vs. Enbrel

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Treats various cancers and kidney disorders. As with all chemotherapy, Cytoxan (cyclophosphamide) has many side effects but is also very effective against different cancers.Calms down your immune system to prevent joint damage. Enbrel (etanercept) effectively calms down your immune system, but it puts you at risk of serious infections.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for cyclophosphamide
Best available price for 30 (50mg) capsules of cyclophosphamide
Coupons for Enbrel
Best available price for 3.92 (4 sureclicks of 50mg) cartons of enbrel
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Cytoxan (cyclophosphamide)?
Worth itNot sureNot worth it
Reviews for Enbrel
-62% worse vs. cyclophosphamide
-53% worse vs. cyclophosphamide
+17% better vs. cyclophosphamide
Have you used Enbrel (etanercept)?
Worth itNot sureNot worth it
Side effects

The cyclophosphamide FDA package insert doesn’t have numbers about how common side effects are.

More about cyclophosphamide side effects »
  • Infections 11%
  • Upper airway infections 8%
  • Injection site reactions 26%
  • Non-upper respiratory infections 6%
  • Rash 1%
  • Fever 3%
  • Itchiness 1%
More Enbrel side effects »
How it works
Cytoxan (cyclophosphamide) works by stopping cancer cells from multiplying.Enbrel (etanercept) blocks a protein called TNF (tumor necrosis factor) in the immune system which lowers inflammation, relieves symptoms and prevents disease progression.
Type of medication
Prescription onlyPrescription only
Available as
  • Pill
  • Injection
  • Injection
Used for
Risk factors for serious side effects
  • Dehydration
  • Urinary tract infections
  • Previous liver disease
  • Previous radiation to abdomen
  • Poor prognosis
Detailed Cytoxan (cyclophosphamide) risks & warnings »
  • Latex allergy
  • History of heart failure
  • Taking other immunosuppressant drugs
  • Age 65 or older
Detailed Enbrel (etanercept) risks & warnings »
Kidneys and liver
  • Cytoxan (cyclophosphamide) can cause kidney or bladder problems or make you at risk of getting kidney infections. To stop this from happening, you should drink plenty of liquids and urinate often. If you have pink or red urine or pain on urination, tell your doctor right away.
  • Effective when used in combination with other anticancer agents or by itself against blood cancers and a kidney disease known as minimal change nephrotic syndrome.
  • Cytoxan (cyclophosphamide) can seriously damage the kidneys.
No kidneys and liver related info.
  • Cytoxan (cyclophosphamide) can cause liver damage. You're more likely to have this if you're taking certain other chemotherapy drugs or getting radiation throughout your entire body. If you have sudden weight gain, swelling of your stomach, fluid build up in your abdomen, yellowing skin or eyes, dark urine or pale stools, talk to your doctor right away.
No weight related info.
Upsides and benefits
  • Effective when used in combination with other anticancer agents or by itself against blood cancers and a kidney disease known as minimal change nephrotic syndrome.
  • Cytoxan (cyclophosphamide) is one of the most well-known medications for cancer, so doctors know what to expect.
  • Available in generic and in both a pill or as an injection.
  • People taking Enbrel (etanercept) for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop their other RA medicines.
  • Enbrel (etanercept) can work for you even if other medications didn't help your rheumatoid arthritis.
  • Enbrel (etanercept) is the first biologic approved for moderate to severe rheumatoid arthritis. Since it has been around for a long time, its side effects are well known.
  • Many people have only minor or no side effects.
  • It's available as a pre-filled syringe and SureClick auto-injector pen which some people find more convenient and easier to use.
Downsides and risks
  • Cytoxan (cyclophosphamide) can seriously damage the kidneys.
  • Cytoxan (cyclophosphamide) can cause many different side effects throughout the body.
  • Cytoxan (cyclophosphamide) is more likely to cause nausea and vomiting compared to other chemotherapy drugs.
  • Cytoxan (cyclophosphamide) can cause infertility.
  • Enbrel (etanercept) raises your risk of serious or life-threatening infections, including tuberculosis (TB).
  • Enbrel (etanercept) can increase the risk of lymphoma, leukemia and other cancers.
  • May not be the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
  • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Enbrel (etanercept).
  • You could get injection site reactions such as redness, swelling, rash, itching, or bruising.
Tips from our pharmacists for people taking the medication
  • This medication comes in an injection or pill. You and your doctor will decide what form is most appropriate for you.
  • Drink plenty of fluids to prevent urinary problems.
  • You should protect yourself and your sexual partners from getting pregnant while taking Cytoxan (cyclophosphamide) for at least 4 months if you're a male or a year if you're female.
  • You're more likely to get sick or heal slower while taking Cytoxan (cyclophosphamide). Talk to your doctor before getting any vaccines.
  • Talk to your doctor if you start having breathing problems that don't go away.
  • Enbrel (etanercept) is available as an injection and a SureClick Autoinjector. You and your doctor can discuss which is best for you.
  • Enbrel (etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once you learn how to do it correctly.
  • Enbrel (etanercept) lowers your immune system's ability to fight infections including tuberculosis (TB), fungal, viral, and bacterial infections. Your doctor will check for TB and hepatitis B before starting Enbrel (etanercept). Let your doctor know if you come down with a fever, cough, or notice flu-like symptoms before or during treatment.
  • Enbrel (etanercept) can cause redness, rash, swelling, itching, or bruising at the site of injection. Do not inject into skin that's already red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
  • Keep Enbrel (etanercept) refrigerated, but let it rest at room temperature for 30 to 60 minutes before using it. Enbrel (etanercept) should not be used if kept at room temperature for longer than 14 days.
  • You should not receive certain vaccinations with Enbrel (etanercept). Discuss with your doctor about your vaccine history and whether you need to receive any vaccines before treatment.
Learn more
More about cyclophosphamideSide effectsAlternativesFDA package insert
Have you used Cytoxan (cyclophosphamide)?
Worth itNot sureNot worth it
More about EnbrelSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Enbrel (etanercept)?
Worth itNot sureNot worth it