Compare cyclophosphamide vs. Humira

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Treats various cancers and kidney disorders. As with all chemotherapy, Cytoxan (cyclophosphamide) has many side effects but is also very effective against different cancers.Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.
Reviews & ratings
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Have you used Cytoxan (cyclophosphamide)?
Worth itNot sureNot worth it
Reviews for Humira
-60% worse vs. cyclophosphamide
-51% worse vs. cyclophosphamide
+26% better vs. cyclophosphamide
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
Side effects

The cyclophosphamide FDA package insert doesn’t have numbers about how common side effects are.

More about cyclophosphamide side effects »
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »
How it works
Cytoxan (cyclophosphamide) works by stopping cancer cells from multiplying.Humira (adalimumab) is a TNF blocker which stops inflammation.
Type of medication
Prescription onlyPrescription only
Available as
  • Pill
  • Injection
  • Injection
Used for
Risk factors for serious side effects
  • Dehydration
  • Urinary tract infections
  • Previous liver disease
  • Previous radiation to abdomen
  • Poor prognosis
Detailed Cytoxan (cyclophosphamide) risks & warnings »
  • Taking other immunosuppressant medications such as Kineret or Orencia
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • Comorbidities
  • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
Detailed Humira (adalimumab) risks & warnings »

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Kidneys and liver
  • Cytoxan (cyclophosphamide) can cause kidney or bladder problems or make you at risk of getting kidney infections. To stop this from happening, you should drink plenty of liquids and urinate often. If you have pink or red urine or pain on urination, tell your doctor right away.
  • Effective when used in combination with other anticancer agents or by itself against blood cancers and a kidney disease known as minimal change nephrotic syndrome.
  • Cytoxan (cyclophosphamide) can seriously damage the kidneys.
No kidneys and liver related info.
  • Cytoxan (cyclophosphamide) can cause liver damage. You're more likely to have this if you're taking certain other chemotherapy drugs or getting radiation throughout your entire body. If you have sudden weight gain, swelling of your stomach, fluid build up in your abdomen, yellowing skin or eyes, dark urine or pale stools, talk to your doctor right away.
No weight related info.
Upsides and benefits
  • Effective when used in combination with other anticancer agents or by itself against blood cancers and a kidney disease known as minimal change nephrotic syndrome.
  • Cytoxan (cyclophosphamide) is one of the most well-known medications for cancer, so doctors know what to expect.
  • Available in generic and in both a pill or as an injection.
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
Downsides and risks
  • Cytoxan (cyclophosphamide) can seriously damage the kidneys.
  • Cytoxan (cyclophosphamide) can cause many different side effects throughout the body.
  • Cytoxan (cyclophosphamide) is more likely to cause nausea and vomiting compared to other chemotherapy drugs.
  • Cytoxan (cyclophosphamide) can cause infertility.
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
Tips from our pharmacists for people taking the medication
  • This medication comes in an injection or pill. You and your doctor will decide what form is most appropriate for you.
  • Drink plenty of fluids to prevent urinary problems.
  • You should protect yourself and your sexual partners from getting pregnant while taking Cytoxan (cyclophosphamide) for at least 4 months if you're a male or a year if you're female.
  • You're more likely to get sick or heal slower while taking Cytoxan (cyclophosphamide). Talk to your doctor before getting any vaccines.
  • Talk to your doctor if you start having breathing problems that don't go away.
  • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
  • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
  • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
Learn more
More about cyclophosphamideSide effectsAlternativesFDA package insert
Have you used Cytoxan (cyclophosphamide)?
Worth itNot sureNot worth it
More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it