Compare cyclophosphamide vs. Humira

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cytoxan (cyclophosphamide)

Prescription only

Humira (adalimumab)

Prescription only
Treats various cancers and kidney disorders.

As with all chemotherapy, Cytoxan (cyclophosphamide) has many side effects but is also very effective against different cancers.

Calms down the immune system.

Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.

4.9/ 7 average rating with 182 reviewsforHumira
Upsides
  • Effective when used in combination with other anticancer agents or by itself against blood cancers and a kidney disease known as minimal change nephrotic syndrome.
  • Cytoxan (cyclophosphamide) is one of the most well-known medications for cancer, so doctors know what to expect.
  • Available in generic and in both a pill or as an injection.
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
Downsides
  • Cytoxan (cyclophosphamide) can seriously damage the kidneys.
  • Cytoxan (cyclophosphamide) can cause many different side effects throughout the body.
  • Cytoxan (cyclophosphamide) is more likely to cause nausea and vomiting compared to other chemotherapy drugs.
  • Cytoxan (cyclophosphamide) can cause infertility.
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
Used for
Dosage forms
  • Pill
  • Injection
  • Injection
Price
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$369.95
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$4537.05
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Reviews
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182 
60%
think this treatment is worth it
51%
think this treatment works well
26%
think this treatment is a hassle

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Side effects
The Cytoxan (cyclophosphamide) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Upper airway infection
    17%
  • Headache
    12%
  • Rash
    12%
  • Sinus infection
    11%
  • Nausea
    9%
  • Injection site reactions
    8%
  • Urinary tract infection
    8%
  • Flu syndrome
    7%
  • Stomach pain
    7%
  • High cholesterol
    7%
See more detailed side effects
Risks and warnings
  • Kidney disease

    Dehydration

    ...and 1 more risk factors

  • Liver disease

    Previous liver disease

    ...and 2 more risk factors

  • Heart disease

    Previous radiation to chest

    ...and 4 more risk factors

See more detailed risks and warnings
  • Serious infections

    Taking other immunosuppressant medications such as Kineret or Orencia

    ...and 3 more risk factors

  • Cancers

    Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)

    ...and 3 more risk factors

  • Heart problems

    History of heart failure

  • Nervous system effects

    Preexisting or recently acquired neurologic condition

See more detailed risks and warnings