Compare cyclophosphamide vs. Remicade

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cytoxan
(cyclophosphamide)

Remicade
(infliximab)

Treats various cancers and kidney disorders. As with all chemotherapy, Cytoxan (cyclophosphamide) has many side effects but is also very effective against different cancers.Calms down your immune system. Remicade (infliximab) is an effective treatment for many autoimmune diseases, but you can have serious side effects.
Reviews & ratings
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Have you used Cytoxan (cyclophosphamide)?
Worth itNot sureNot worth it
Reviews for Remicade
76%
-76% worse vs. cyclophosphamide
62%
-62% worse vs. cyclophosphamide
15%
+15% better vs. cyclophosphamide
Have you used Remicade (infliximab)?
Worth itNot sureNot worth it
Side effects
cyclophosphamideRemicade

The cyclophosphamide FDA package insert doesn’t have numbers about how common side effects are.

More about cyclophosphamide side effects »
  • Upper airway infection 7%
  • Nausea 1%
  • Headache 4%
  • Sinus infection 6%
  • Sore throat 4%
  • Coughinng 4%
  • Abdominal pain 4%
  • Bronchitis 1%
  • Rash 5%
More Remicade side effects »
How it works
cyclophosphamideRemicade
Cytoxan (cyclophosphamide) works by stopping cancer cells from multiplying.Remicade (infliximab) blocks a protein in your immune system called TNF (tumor necrosis factor) that causes inflammation.
Type of medication
cyclophosphamideRemicade
Prescription onlyPrescription only
Available as
cyclophosphamideRemicade
  • Pill
  • Injection
  • Injection
Used for
cyclophosphamideRemicade
Risk factors for serious side effects
cyclophosphamideRemicade
  • Dehydration
  • Urinary tract infections
  • Previous liver disease
  • Previous radiation to abdomen
  • Poor prognosis
Detailed Cytoxan (cyclophosphamide) risks & warnings »
  • Taking other immunosuppressant drugs
  • Age 65 or older
  • Comorbidities
  • History of malignancy
Detailed Remicade (infliximab) risks & warnings »
Pregnancy
Kidneys and liver
cyclophosphamideRemicade
  • Cytoxan (cyclophosphamide) can cause kidney or bladder problems or make you at risk of getting kidney infections. To stop this from happening, you should drink plenty of liquids and urinate often. If you have pink or red urine or pain on urination, tell your doctor right away.
  • Effective when used in combination with other anticancer agents or by itself against blood cancers and a kidney disease known as minimal change nephrotic syndrome.
  • Cytoxan (cyclophosphamide) can seriously damage the kidneys.
No kidneys and liver related info.
Weight
cyclophosphamideRemicade
  • Cytoxan (cyclophosphamide) can cause liver damage. You're more likely to have this if you're taking certain other chemotherapy drugs or getting radiation throughout your entire body. If you have sudden weight gain, swelling of your stomach, fluid build up in your abdomen, yellowing skin or eyes, dark urine or pale stools, talk to your doctor right away.
  • Although rare, Remicade (infliximab) can hurt your liver. If you have appetite/weight loss, stomach discomfort, vomiting, or dark urine, talk to your doctor. If you have yellowing of skin/eyes, talk to your doctor right away.
Upsides and benefits
cyclophosphamideRemicade
  • Effective when used in combination with other anticancer agents or by itself against blood cancers and a kidney disease known as minimal change nephrotic syndrome.
  • Cytoxan (cyclophosphamide) is one of the most well-known medications for cancer, so doctors know what to expect.
  • Available in generic and in both a pill or as an injection.
  • People taking Remicade (infliximab) for ulcerative colitis, Crohn's disease, rheumatoid arthritis and other autoimmune conditions had more clinical response, clinical remission and symptom improvement compared to people who did not take Remicade (infliximab).
  • People who were also taking steroids for treatment were able to discontinue steroid use while taking Remicade (infliximab).
  • Remicade (infliximab) has almost two decades of clinical trial data and real-life experience with many people who have used it.
  • After the initial dosing, you only need to take Remicade (infliximab) every 6-8 weeks, depending on your condition.
  • Compared to other medications used to treat autoimmune conditions, Remicade (infliximab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
Downsides and risks
cyclophosphamideRemicade
  • Cytoxan (cyclophosphamide) can seriously damage the kidneys.
  • Cytoxan (cyclophosphamide) can cause many different side effects throughout the body.
  • Cytoxan (cyclophosphamide) is more likely to cause nausea and vomiting compared to other chemotherapy drugs.
  • Cytoxan (cyclophosphamide) can cause infertility.
  • You have to receive this medication at your doctor's office or clinic. You might need to be tested regularly for tuberculosis.
  • Remicade (infliximab) lowers your ability to fight infection and can cause serious illness. The risk is greater if you take other drugs that lower your immune system, or have a history of diabetes or tuberculosis.
  • Remicade (infliximab) can in some cases worsen symptoms of heart failure or neurologic conditions. People 65 years and older may have more side effects from this medication.
  • In rare cases, Remicade (infliximab) has been associated with cancers in children and adolescents.
  • No generic available, so it can be costly.
Tips from our pharmacists for people taking the medication
cyclophosphamideRemicade
  • This medication comes in an injection or pill. You and your doctor will decide what form is most appropriate for you.
  • Drink plenty of fluids to prevent urinary problems.
  • You should protect yourself and your sexual partners from getting pregnant while taking Cytoxan (cyclophosphamide) for at least 4 months if you're a male or a year if you're female.
  • You're more likely to get sick or heal slower while taking Cytoxan (cyclophosphamide). Talk to your doctor before getting any vaccines.
  • Talk to your doctor if you start having breathing problems that don't go away.
  • Remicade (infliximab) can in some cases cause a serious allergic reaction either immediately or several days after the treatment. Your doctor can give you medicines that will lower this risk.
  • Your doctor will test you for tuberculosis before taking Remicade (infliximab) and regularly during treatment.
  • Remicade (infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms.
  • You should not receive any live vaccines while taking Remicade (infliximab). Tell your doctor that you are taking Remicade (infliximab) before receiving any vaccines.
  • If you have any signs or new or worsening symptoms such as heart, neurological, or autoimmune conditions, talk to your doctor. Tell your doctor about symptoms such as bruising or bleeding.
Learn more
More about cyclophosphamideSide effectsAlternativesFDA package insert
Have you used Cytoxan (cyclophosphamide)?
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More about RemicadeSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Remicade (infliximab)?
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