Compare Cyclosporine vs. Stelara

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats moderate to severe psoriasis.

Stelara (Ustekinumab) works for two psoriatic conditions. It may be somewhat of a hassle because of the injection, but after the first two doses, you only need to take it every 12 weeks.

3.1/ 5 average rating with 50 reviewsforStelara
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  • Stelara (Ustekinumab) works throughout your whole body (systemic therapy) and may be better than just applying medicine to your skin (local therapy) for moderate or severe plaque psoriasis that covers large areas or many areas of your body.
  • It's used alone or together with another medicine called methotrexate for better results to treat active psoriatic arthritis.
  • Initial dosing might be a hassle, but then you only have to take it every 12 weeks.
  • People treated with Stelara (Ustekinumab) for psoriatic arthritis felt better and had more physical improvement compared to not using the medicine (placebo).
No information currently available
  • It's an injection.
  • Stelara (Ustekinumab) lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You have to get your first dose of Stelara (Ustekinumab) at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
  • You'll need to properly dispose of the needle and syringes in a special (FDA-approved) sharps container.
  • Because Stelara (Ustekinumab) needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
Used for
  • Cardiac transplant rejection; Prophylaxis Liver transplant rejection; Prophylaxis Plaque psoriasis (Severe)
  • Recalcitrant
  • In nonimmunocompromised patients Renal transplant rejection; Prophylaxis Rheumatoid arthritis (Severe)
  • With inadequate response to methotrexate
Dosage forms
  • Pill
  • Liquid
  • Injection
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Side effects
The Neoral (Cyclosporine) FDA package insert doesn’t have numbers about how common side effects are.
1possible side effects
  • Immunogenicity
See more detailed side effects
Risks and risk factors
No information currently available
  • Serious Infections
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • Weak immune system
  • Possible infections
  • Serious allergic reactions
  • Malignancy
    • Age 60 or older
    • Long-term use of drugs that suppress the immune system
    • History of PUVA (photochemotherapy)
  • Nervous system effects
    • Preeclampsia/eclampsia
    • Acute hypertension
    • Taking other drugs that suppress the immune system
    • Taking cytotoxic chemotherapy
  • Drug interactions
  • Risk to fetus
See more detailed risks and warnings