Compare Cymbalta vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cymbalta
(Duloxetine)

Depacon
(Valproate, Valproic Acid, Or Divalproex)

Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.873479318734793Cymbalta
Reviews for Cymbalta (Duloxetine)
59%
of people say Cymbalta (Duloxetine) is worth it
49%
say it works well
24%
say it's a big hassle
Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
46%
13% vs. Cymbalta (Duloxetine)
39%
10% vs. Cymbalta (Duloxetine)
27%
3% vs. Cymbalta (Duloxetine)
Side effects
CymbaltaDepakote
  • Nausea 15%
  • Dry mouth 8%
  • Drowsiness 8%
  • Constipation 7%
  • Somnolencee 7%
  • Decreased appetite 7%
  • Fatigued 6%
  • Sleep difficulty 5%
  • Dizziness 4%
  • Fatigue 4%
More Cymbalta side effects »
  • Nausea 34%
  • Muscle weakness 20%
  • Vomiting 20%
  • Abdominal pain 17%
  • Dizziness 12%
  • Headache 10%
  • Double vision 7%
  • Involuntary eye movement 7%
  • Lack of muscle coordination 7%
  • Accidental injury 6%
More Depakote side effects »
How it works
CymbaltaDepakote
Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.
Type of medication
CymbaltaDepakote
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
AnticonvulsantPrescription only
Available as
CymbaltaDepakote
  • Extended release
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Used for (click to learn more)
CymbaltaDepakote
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.

After 4 weeks using Start and Cymbalta (Duloxetine), here’s how much better people feel.

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Depacon (Valproate, Valproic Acid, Or Divalproex)
Risk factors for serious side effects
CymbaltaDepakote
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Cymbalta (Duloxetine) risks & warnings »
      • Children under age 2
      • History of metabolic disorders
        • History of depression
          • History of metabolic disorders
          • People also taking Topamax
          • People also taking Topamax
            • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
            Detailed Depacon (Valproate, Valproic Acid, Or Divalproex) risks & warnings »
            Pregnancy category
            CymbaltaDepakote
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            DFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            Alcohol
            No specific alcohol-related info.No specific alcohol-related info.
            Food
            • Take with food to avoid upset stomach.
            • Take with food to avoid upset stomach.
            Kidneys and liver
            • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
            No specific kidneys and liver-related info.
            Sex
            • Cymbalta (Duloxetine) can cause lower sex drive or difficulty having an orgasm. If the problem persists after the first 2 to 3 months, you can talk to your doctor about alternative antidepressants or performance-enhancing medications.
            No specific sex-related info.
            Sleep
            • Stopping Cymbalta (Duloxetine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3 days of stopping the medication, and go away within 1 to 2 weeks. Work with your doctor to gradually reduce your dose.
            No specific sleep-related info.
            Weight
            No specific weight-related info.
            • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
            • May cause hair loss and weight gain.
            Upsides and benefits
            CymbaltaDepakote
            • Effective at relieving depression and anxiety symptoms.
            • Lowers relapse rates for depression.
            • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
            • Six out of ten people who use an antidepressant for the first time find that it works for them.
            • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
            • One of the first-line options to stabilize mood for people with bipolar disorder.
            • Helpful in preventing frequent migraine headaches.
            Downsides and risks
            CymbaltaDepakote
            • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
            • Not the best option for people with high blood pressure.
            • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
            • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
            • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
            • Can cause liver damage, so it's probably not safe if you already have liver problems.
            • Not safe to use if you're pregnant.
            • Requires routine blood tests to see how the medicine is affecting your body.
            Tips from our pharmacists for people taking the medication
            CymbaltaDepakote
            • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
            • Stop taking slowly to avoid withdrawal symptoms.
            • Tell your doctor if you notice sudden mood changes or unusual thoughts.
            • Take with food to avoid upset stomach.
            • For the first week, avoid activities that require you to be alert.
            • Don't use if pregnant.
            • Requires routine blood tests.
            • May cause hair loss and weight gain.
            • Different versions of Depakote have different dosing. Be careful.
            • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
            • Takes 3 to 4 weeks to feel full effects on mood.
            • Take with food to avoid upset stomach.
            Learn more
            More about CymbaltaSide effectsReviews & ratingsAlternativesFDA package insert
            More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert