Compare Cymbalta vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Improves mood and relieves certain types of pain.

Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure.

3.6/ 5 average rating with 496 reviewsforCymbalta
Prevents seizures and stabilizes mood.

Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.

3.3/ 5 average rating with 97 reviewsforDepakote
Upsides
  • Cymbalta (duloxetine) may help relieve nerve pain from diabetes and other forms of chronic pain.
  • Cymbalta (duloxetine) has several uses, which may be good for people with multiple conditions.
  • Available as a generic, which is cheaper.
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
Downsides
  • Cymbalta (duloxetine) may not be a good option if you're a heavy drinker, or have liver or kidney problems.
  • Cymbalta (duloxetine) can increase high blood pressure.
  • Like most antidepressants, Cymbalta (duloxetine) can cause higher risk of suicidal thoughts and behavior for people aged 24 and younger.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Price
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Reviews
496 reviews so far
58%
saidit'sworth it
49%
saiditworked well
24%
saidit'sa big hassle

Have you used Cymbalta (duloxetine)?

Leave a review
97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?

Leave a review
Side effects
12possible side effects
  • Nausea
    23%
  • Headache
    14%
  • Dry mouth
    13%
  • Drowsiness
    10%
  • Fatigue
    9%
  • Difficulty sleeping
    9%
  • Constipation
    9%
  • Dizziness
    9%
  • Diarrhea
    9%
  • Decreased appetite
    7%
  • Excessive sweating
    6%
  • Abdominal pain
    5%
See more detailed side effects
26possible side effects
  • Nausea
    48%
  • Headache
    31%
  • Asthenia
    27%
  • Vomiting
    27%
  • Somnolence
    27%
  • Tremor
    25%
  • Dizziness
    25%
  • Abdominal Pain
    23%
  • Diplopia
    16%
  • Diarrhea
    13%
  • Anorexia
    12%
  • Amblyopia/Blurred Vision
    12%
  • Flu Syndrome
    12%
  • Infection
    12%
  • Dyspepsia
    8%
  • Ataxia
    8%
  • Nystagmus
    8%
  • Fever
    6%
  • Emotional Lability
    6%
  • Thinking Abnormal
    6%
  • Alopecia
    6%
  • Weight Loss
    6%
  • Constipation
    5%
  • Amnesia
    5%
  • Bronchitis
    5%
  • Rhinitis
    5%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
  • Withdrawal
    • Stopping Cymbalta (duloxetine) abruptly
  • Increased bleeding
    • Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
  • Changes in blood pressure and risk of falls
    • Elderly patients
    • History of gait disturbances
    • Taking more than 60 mg of Cymbalta (duloxetine) daily
    • Taking other medicines that lower blood pressure
    • History of high blood pressure
  • Bipolar disorder
    • History of bipolar disorder
    • At risk for bipolar disorder
See more detailed risks and warnings
  • Pregnancy
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
  • Pancreatitis
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes due to high ammonia
    • History of metabolic disorders
    • People also taking Topamax
  • Low body temperature
    • People also taking Topamax
  • Serious allergic reactions
  • Withdrawal seizures
    • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
See more detailed risks and warnings