Compare Cymbalta vs. Effexor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cymbalta
(Duloxetine)

Effexor
(Venlafaxine)

Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. May work when other antidepressants haven't, it's but more likely to cause side effects and withdrawal symptoms than other antidepressants.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.84Cymbalta
Reviews for Cymbalta (Duloxetine)
58%
of people (All ages) say Cymbalta (Duloxetine) is worth it
49%
say it works well
24%
say it's a big hassle
496 reviews
Have you used Cymbalta (Duloxetine)?
Worth itNot sureNot worth it
Reviews for Effexor (Venlafaxine)
62%
+4% vs. Cymbalta (Duloxetine)
51%
+2% vs. Cymbalta (Duloxetine)
23%
+1% vs. Cymbalta (Duloxetine)
577 reviews
Have you used Effexor (Venlafaxine)?
Worth itNot sureNot worth it
Side effects
CymbaltaEffexor

The Cymbalta FDA package insert doesn’t have numbers about how common side effects are.

More about Cymbalta side effects »
  • Nausea 42%
  • Drowsiness 22%
  • Dizziness 20%
  • Nervousness 17%
  • Loss of appetite 15%
  • Sweating 14%
  • Muscle weakness 14%
  • Sleep difficulty 13%
  • Anxiety 7%
  • Vomiting 7%
More Effexor side effects »
How it works
CymbaltaEffexor
Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.
Type of medication
CymbaltaEffexor
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Available as
CymbaltaEffexor
  • Extended release
  • Pill
  • Extended release
Used for (click to learn more)
CymbaltaEffexor
Risk factors for serious side effects
CymbaltaEffexor
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
Detailed risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Effexor (Venlafaxine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
CymbaltaEffexor
  • Take with food to avoid upset stomach.
No food related info.
Kidneys and liver
CymbaltaEffexor
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
No kidneys and liver related info.
Pain
CymbaltaEffexor
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
No pain related info.
Sex
CymbaltaEffexor
No sex related info.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
Upsides and benefits
CymbaltaEffexor
  • Lowers relapse rates for depression.
  • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
  • Effective at relieving depression and anxiety symptoms.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Lowers relapse rates of depression.
  • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
  • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
  • Effective at relieving depression and anxiety symptoms.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
CymbaltaEffexor
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • Not the best option for people with high blood pressure.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Overdosing on this medication could be fatal.
  • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • Not the best option for people with high blood pressure.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
CymbaltaEffexor
  • Take with food to avoid upset stomach.
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
  • Stop taking slowly to avoid withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
  • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about CymbaltaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cymbalta (Duloxetine)?
Worth itNot sureNot worth it
More about EffexorSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Effexor (Venlafaxine)?
Worth itNot sureNot worth it