Compare Cymbalta vs. Klonopin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cymbalta
(duloxetine)

Klonopin
(clonazepam)

Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Controls seizures and helps you relax. Klonopin (Clonazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and to treat seizures. Less severe withdrawal symptoms compared to similar drugs.
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Prices and coupon for 30 (60mg) capsules of duloxetine
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Prices and coupon for 60 (0.5mg) tablets of clonazepam
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.84Cymbalta
Reviews for Cymbalta (duloxetine)
58%
of people (All ages) say Cymbalta (duloxetine) is worth it
49%
say it works well
24%
say it's a big hassle
496 reviews
Have you used Cymbalta (duloxetine)?
Worth itNot sureNot worth it
Reviews for Klonopin (clonazepam)
70%
+12% better vs. Cymbalta (duloxetine)
52%
+3% better vs. Cymbalta (duloxetine)
14%
+10% better vs. Cymbalta (duloxetine)
767 reviews
Have you used Klonopin (clonazepam)?
Worth itNot sureNot worth it
Side effects
CymbaltaKlonopin
  • Nausea 15%
  • Headache 2%
  • Dry mouth 8%
  • Somnolencee 7%
  • Fatigue 4%
  • Sleep difficulty 4%
  • Constipation 5%
  • Dizziness 4%
  • Diarrhea 3%
  • Decreased appetite 5%
More Cymbalta side effects »
  • Drowsiness 50%
  • Lack of muscle coordination 30%
  • Behavior problems 25%
  • Ear, nose, or throat infection 6%
  • Fatigue 5%
  • Low mood disorder 6%
  • Dizziness 1%
  • Vaginal inflammation 3%
  • Sinus inflammation 1%
  • Inflammation inside the nose 2%
More Klonopin side effects »
How it works
CymbaltaKlonopin
Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Klonopin (Clonazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.
Type of medication
CymbaltaKlonopin
Prescription only
Prescription only
Available as
CymbaltaKlonopin
  • Extended release
  • Pill
  • Dissolving tablet
Used for
CymbaltaKlonopin
Risk factors for serious side effects
CymbaltaKlonopin
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Cymbalta (duloxetine) risks & warnings »
    • Taking more than the prescribed dose
    • Taking longer than 4 weeks
    • History of drug abuse
    • Long-term use
      • Alcohol
      • Taking other medicines that make you less alert
        Detailed Klonopin (clonazepam) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Alcohol
        CymbaltaKlonopin
        No alcohol related info.
        • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
        • Not safe to use with alcohol.
        Food
        CymbaltaKlonopin
        • Take with food to avoid upset stomach.
        No food related info.
        Kidneys and liver
        CymbaltaKlonopin
        • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
        No kidneys and liver related info.
        Pain
        CymbaltaKlonopin
        • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
        No pain related info.
        Sleep
        CymbaltaKlonopin
        No sleep related info.
        • Can cause memory problems, drowsiness, dizziness, and confusion.
        • Can cause dizziness, drowsiness, and salivation.
        Upsides and benefits
        CymbaltaKlonopin
        • Effective at relieving depression and anxiety symptoms.
        • Lowers relapse rates for depression.
        • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Effective at relieving short-term anxiety and sleeplessness.
        • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
        • Can be used alone or with other medicines to treat seizures.
        • Less severe withdrawal symptoms compared to other benzodiazepines.
        Downsides and risks
        CymbaltaKlonopin
        • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
        • Not the best option for people with high blood pressure.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • Can cause memory problems, drowsiness, dizziness, and confusion.
        • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
        • Most people find that it gets less effective over time.
        Tips from our pharmacists for people taking the medication
        CymbaltaKlonopin
        • Take with food to avoid upset stomach.
        • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
        • Stop taking slowly to avoid withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • For the first week, avoid activities that require you to be alert.
        • Can cause dizziness, drowsiness, and salivation.
        • Report any confusion or inability to control muscle movements to your doctor.
        • Not safe to use with alcohol.
        Learn more
        More about CymbaltaSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Cymbalta (duloxetine)?
        Worth itNot sureNot worth it
        More about KlonopinSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Klonopin (clonazepam)?
        Worth itNot sureNot worth it