Compare Cymbalta vs. Lamictal

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cymbalta (duloxetine)

Prescription only

Lamictal (Lamotrigine)

Prescription only
Improves mood and relieves certain types of pain.

Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure.

4.8/ 7 average rating with 496 reviewsforCymbalta
Prevents seizures and stabilizes mood.

Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.

5.1/ 7 average rating with 184 reviewsforLamictal
Upsides
  • Cymbalta (duloxetine) may help relieve nerve pain from diabetes and other forms of chronic pain.
  • Cymbalta (duloxetine) has several uses, which may be good for people with multiple conditions.
  • Available as a generic, which is cheaper.
  • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
  • Works best for partial, tonic-clonic, and absence seizures.
  • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
  • Doesn't require routine blood tests.
Downsides
  • Cymbalta (duloxetine) may not be a good option if you're a heavy drinker, or have liver or kidney problems.
  • Cymbalta (duloxetine) can increase high blood pressure.
  • Like most antidepressants, Cymbalta (duloxetine) can cause higher risk of suicidal thoughts and behavior for people aged 24 and younger.
  • Can cause double vision, dizziness, sleepiness, and headache.
  • Has the risk of a rare but life-threatening rash.
  • Can make hormonal birth control less effective.
  • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
Price
Lowest price near you
$16.25
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Lowest price near you
$8.7
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Reviews
496 
58%
think this treatment is worth it
49%
think this treatment works well
24%
think this treatment is a hassle

Have you used Cymbalta (duloxetine)?

Leave a review
184 
66%
think this treatment is worth it
58%
think this treatment works well
18%
think this treatment is a hassle

Have you used Lamictal (Lamotrigine)?

Leave a review
Side effects
10possible side effects
  • Nausea
    23%
  • Headache
    14%
  • Dry mouth
    13%
  • Drowsiness
    10%
  • Fatigue
    9%
  • Difficulty sleeping
    9%
  • Constipation
    9%
  • Dizziness
    9%
  • Diarrhea
    9%
  • Decreased appetite
    7%
See more detailed side effects
10possible side effects
  • Dizziness
    38%
  • Headache
    28%
  • Diplopia
    28%
  • Ataxia
    22%
  • Nausea
    19%
  • Blurred vision
    16%
  • Somnolence
    14%
  • Rhinitis
    14%
  • Pharyngitis
    10%
  • Rash
    10%
See more detailed side effects
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort

  • Withdrawal

    Stopping Cymbalta (duloxetine) abruptly

  • Increased bleeding

    Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)

  • Changes in blood pressure and risk of falls

    Elderly patients

    ...and 4 more risk factors

  • Bipolar disorder

    History of bipolar disorder

    ...and 1 more risk factors

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    History of depression

  • Serious skin rash

    People also taking Depakote

    ...and 2 more risk factors

  • Interactions with birth control pills

    Taking birth control pills

  • Withdrawal seizures

    Stopping Lamictal (Lamotrigine) suddenly

See more detailed risks and warnings