Compare Cymbalta vs. Lamictal

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cymbalta
(duloxetine)

Lamictal
(lamotrigine)

Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Prevents seizures and stabilizes mood. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.
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Coupons for Cymbalta
Best available price for 30 (60mg) capsules of duloxetine
Coupons for Lamictal
Best available price for 30 (100mg) tablets of lamotrigine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.84Cymbalta
Reviews for Cymbalta (duloxetine)
58%
of people (All ages) say Cymbalta (duloxetine) is worth it
49%
say it works well
24%
say it's a big hassle
496 reviews
Have you used Cymbalta (duloxetine)?
Worth itNot sureNot worth it
Reviews for Lamictal (lamotrigine)
66%
+8% better vs. Cymbalta (duloxetine)
58%
+9% better vs. Cymbalta (duloxetine)
18%
+6% better vs. Cymbalta (duloxetine)
184 reviews
Have you used Lamictal (lamotrigine)?
Worth itNot sureNot worth it
Side effects
CymbaltaLamictal
  • Nausea 15%
  • Headache 2%
  • Dry mouth 8%
  • Somnolencee 7%
  • Fatigue 4%
  • Sleep difficulty 4%
  • Constipation 5%
  • Dizziness 4%
  • Diarrhea 3%
  • Decreased appetite 5%
More Cymbalta side effects »
  • Dizziness 25%
  • Headache 9%
  • Double vision 21%
  • Lack of muscle coordination 16%
  • Nausea 9%
  • Blurred vision 11%
  • Inflammation inside the nose 5%
  • Drowsiness 7%
  • Sore throat 1%
  • Rash 5%
More Lamictal side effects »
How it works
CymbaltaLamictal
Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Lamictal (Lamotrigine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to calm nerve activity in the brain.
Type of medication
CymbaltaLamictal
Prescription only
Prescription only
Available as
CymbaltaLamictal
  • Extended release
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
Used for
CymbaltaLamictal
Risk factors for serious side effects
CymbaltaLamictal
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
Detailed Cymbalta (duloxetine) risks & warnings »
  • History of depression
  • People also taking Depakote
  • Taking more than the prescribed dose
  • Increasing the dose too quickly
  • Taking birth control pills
Detailed Lamictal (lamotrigine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
CymbaltaLamictal
  • Take with food to avoid upset stomach.
  • Take with food to avoid upset stomach.
Kidneys and liver
CymbaltaLamictal
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
No kidneys and liver related info.
Pain
CymbaltaLamictal
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
No pain related info.
Upsides and benefits
CymbaltaLamictal
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates for depression.
  • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
  • Works best for partial, tonic-clonic, and absence seizures.
  • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
  • Doesn't require routine blood tests.
Downsides and risks
CymbaltaLamictal
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Not the best option for people with high blood pressure.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Can cause double vision, dizziness, sleepiness, and headache.
  • Has the risk of a rare but life-threatening rash.
  • Can make hormonal birth control less effective.
  • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
Tips from our pharmacists for people taking the medication
CymbaltaLamictal
  • Take with food to avoid upset stomach.
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
  • Stop taking slowly to avoid withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Follow dose adjustments set by your doctor to minimize skin rash.
  • Take with food to avoid upset stomach.
  • Report rash, blurry vision, fever, persistent headache, or neck stiffness to your doctor.
  • Makes hormonal birth control less effective.
  • Takes 4 to 6 weeks to feel full effects on mood.
Learn more
More about CymbaltaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cymbalta (duloxetine)?
Worth itNot sureNot worth it
More about LamictalSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lamictal (lamotrigine)?
Worth itNot sureNot worth it