Compare Cymbalta vs. Lexapro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cymbalta
(Duloxetine)

Lexapro
(Escitalopram)

Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Improves mood and helps you relax. Lexapro (Escitalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.84Cymbalta
Reviews for Cymbalta (Duloxetine)
58%
of people (All ages) say Cymbalta (Duloxetine) is worth it
49%
say it works well
24%
say it's a big hassle
496 reviews
Have you used Cymbalta (Duloxetine)?
Worth itNot sureNot worth it
Reviews for Lexapro (Escitalopram)
61%
+3% vs. Cymbalta (Duloxetine)
48%
1% vs. Cymbalta (Duloxetine)
15%
+9% vs. Cymbalta (Duloxetine)
1063 reviews
Have you used Lexapro (Escitalopram)?
Worth itNot sureNot worth it
Side effects
CymbaltaLexapro

The Cymbalta FDA package insert doesn’t have numbers about how common side effects are.

More about Cymbalta side effects »
  • Sleep difficulty 10%
  • Diarrhea 9%
  • Drowsiness 8%
  • Dry mouth 6%
  • Dizziness 5%
  • Indigestion 5%
  • Constipation 5%
  • Fatigue 4%
More Lexapro side effects »
How it works
CymbaltaLexapro
Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Lexapro (Escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
CymbaltaLexapro
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Available as
CymbaltaLexapro
  • Extended release
  • Pill
  • Liquid
Used for (click to learn more)
CymbaltaLexapro
Risk factors for serious side effects
CymbaltaLexapro
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
Detailed risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Lexapro (Escitalopram) suddenly
  • Higher dose
  • History of heart problems
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
CymbaltaLexapro
  • Take with food to avoid upset stomach.
  • Take with food to avoid upset stomach.
Kidneys and liver
CymbaltaLexapro
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Not a good option for you if you have heart or liver problems.
Pain
CymbaltaLexapro
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
No pain related info.
Sex
CymbaltaLexapro
No sex related info.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
Weight
CymbaltaLexapro
No weight related info.
  • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
Upsides and benefits
CymbaltaLexapro
  • Lowers relapse rates for depression.
  • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
  • Effective at relieving depression and anxiety symptoms.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Lowers relapse rates of depression.
  • Causes less sleepiness than some other antidepressants.
  • Effective at relieving depression and anxiety symptoms.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
CymbaltaLexapro
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Not the best option for people with high blood pressure.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
  • Can cause an irregular heartbeat if you take a high dose (20 mg a day, or more).
  • Not a good option for you if you have heart or liver problems.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work, and might have side effects you really don't like. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
Tips from our pharmacists for people taking the medication
CymbaltaLexapro
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
  • Stop taking slowly to avoid withdrawal symptoms.
  • Take with food to avoid upset stomach.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Take with food to avoid upset stomach.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about CymbaltaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cymbalta (Duloxetine)?
Worth itNot sureNot worth it
More about LexaproSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lexapro (Escitalopram)?
Worth itNot sureNot worth it