Compare Cymbalta vs. Lyrica

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cymbalta (duloxetine)

Prescription only

Lyrica (pregabalin)

Prescription only
Improves mood and relieves certain types of pain.

Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure.

4.8/ 7 average rating with 496 reviewsforCymbalta
Treats pain caused by nerve damage and prevents seizures.

Lyrica (pregabalin) is first-choice treatment for nerve pain, but may be expensive since it is available as brand name only.

4.4/ 7 average rating with 66 reviewsforLyrica
Upsides
  • Cymbalta (duloxetine) may help relieve nerve pain from diabetes and other forms of chronic pain.
  • Cymbalta (duloxetine) has several uses, which may be good for people with multiple conditions.
  • Available as a generic, which is cheaper.
  • Unlike other pain relievers, it is very effective at treating and preventing nerve damage caused by diabetes, shingles, fibromyalgial, and spinal cord injuries.
  • It is less habit forming than narcotics.
  • It can also be used in combination with other anti-seizure medicines to treat epilepsy.
Downsides
  • Cymbalta (duloxetine) may not be a good option if you're a heavy drinker, or have liver or kidney problems.
  • Cymbalta (duloxetine) can increase high blood pressure.
  • Like most antidepressants, Cymbalta (duloxetine) can cause higher risk of suicidal thoughts and behavior for people aged 24 and younger.
  • Likely expensive since it is not available in generic versions.
  • Has a higher risk than other pain medicines to affect your heart rate or rhythm.
  • Requires adjustment in dose if you have lower kidney function.
  • Higher doses can cause drowsiness so you will have to divide the dose and take it throughout the day.
Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
  • Liquid
Price
Lowest price near you
$16.25
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$431.1
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Reviews
496 
58%
think this treatment is worth it
49%
think this treatment works well
24%
think this treatment is a hassle

Have you used Cymbalta (duloxetine)?

Leave a review
66 
47%
think this treatment is worth it
42%
think this treatment works well
32%
think this treatment is a hassle

Have you used Lyrica (pregabalin)?

Leave a review
Side effects
10possible side effects
  • Nausea
    23%
  • Headache
    14%
  • Dry mouth
    13%
  • Drowsiness
    10%
  • Fatigue
    9%
  • Difficulty sleeping
    9%
  • Constipation
    9%
  • Dizziness
    9%
  • Diarrhea
    9%
  • Decreased appetite
    7%
See more detailed side effects
10possible side effects
  • Dizziness
    23%
  • Drowsiness
    13%
  • Headache
    11%
  • Blurry vision
    8%
  • Weight gain
    8%
  • Dry mouth
    7%
  • Fatigue
    5%
  • Swelling of the hands and feet
    5%
  • Constipation
    4%
  • Sinus infection
    4%
See more detailed side effects
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort

  • Withdrawal

    Stopping Cymbalta (duloxetine) abruptly

  • Increased bleeding

    Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)

  • Changes in blood pressure and risk of falls

    Elderly patients

    ...and 4 more risk factors

  • Bipolar disorder

    History of bipolar disorder

    ...and 1 more risk factors

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Starting Lyrica (pregabalin) or changing doses

  • Driving impairment

    Taking Lyrica (pregabalin) with alcohol

    ...and 1 more risk factors

  • Giant hives (angioedema)

    History of unusual swelling (angioedema)

    ...and 1 more risk factors

  • Heart problems

    History of cardiovascular disease

  • Swelling of the hands and feet

    Taking with certain diabetes medications

  • Withdrawal symptoms

    Stopping Lyrica (pregabalin) suddenly

See more detailed risks and warnings