Compare Cymbalta vs. Norpramin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cymbalta
(Duloxetine)

Norpramin
(Desipramine)

Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Coming soon.
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Reviews & ratings
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4.873479318734793Cymbalta
Reviews for Cymbalta (Duloxetine)
59%
of people (All ages) say Cymbalta (Duloxetine) is worth it
49%
say it works well
24%
say it's a big hassle
411 reviews
Have you used Cymbalta (Duloxetine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Norpramin (Desipramine)?
Worth itNot sureNot worth it
Side effects
CymbaltaNorpramin
  • Nausea 15%
  • Dry mouth 8%
  • Drowsiness 8%
  • Constipation 7%
  • Somnolencee 7%
  • Decreased appetite 7%
  • Fatigued 6%
  • Sleep difficulty 5%
  • Dizziness 4%
  • Fatigue 4%
More Cymbalta side effects »

We haven’t found good data for Norpramin side effects.

FDA side effect reports for Norpramin »
How it works
CymbaltaNorpramin
Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Coming soon.
Type of medication
CymbaltaNorpramin
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Coming soon.
Available as
CymbaltaNorpramin
  • Extended release
  • Pill
Used for (click to learn more)
CymbaltaNorpramin
  • Depression
Risk factors for serious side effects
CymbaltaNorpramin
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Cymbalta (Duloxetine) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Food
    CymbaltaNorpramin
    • Take with food to avoid upset stomach.
    No food related info.
    Kidneys and liver
    CymbaltaNorpramin
    • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
    No kidneys and liver related info.
    Pain
    CymbaltaNorpramin
    • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
    No pain related info.
    Upsides and benefits
    CymbaltaNorpramin
    • Effective at relieving depression and anxiety symptoms.
    • Lowers relapse rates for depression.
    • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
    • Six out of ten people who use an antidepressant for the first time find that it works for them.
    Coming soon
    Downsides and risks
    CymbaltaNorpramin
    • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
    • Not the best option for people with high blood pressure.
    • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
    • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
    Coming soon
    Tips from our pharmacists for people taking the medication
    CymbaltaNorpramin
    • Take with food to avoid upset stomach.
    • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
    • Stop taking slowly to avoid withdrawal symptoms.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    Coming soon
    Learn more
    More about CymbaltaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Cymbalta (Duloxetine)?
    Worth itNot sureNot worth it
    More about NorpraminSide effectsReviews & ratingsFDA package insert
    Have you used Norpramin (Desipramine)?
    Worth itNot sureNot worth it