Compare Cymbalta vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cymbalta
(Duloxetine)

Oleptro
(Trazodone)

Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.873479318734793Cymbalta
Reviews for Cymbalta (Duloxetine)
59%
of people (All ages) say Cymbalta (Duloxetine) is worth it
49%
say it works well
24%
say it's a big hassle
411 reviews
Have you used Cymbalta (Duloxetine)?
Worth itNot sureNot worth it
Reviews for Oleptro (Trazodone)
72%
+13% vs. Cymbalta (Duloxetine)
48%
1% vs. Cymbalta (Duloxetine)
24%
Same vs. Cymbalta (Duloxetine)
Have you used Oleptro (Trazodone)?
Worth itNot sureNot worth it
Side effects
CymbaltaOleptro
  • Nausea 15%
  • Dry mouth 8%
  • Drowsiness 8%
  • Constipation 7%
  • Somnolencee 7%
  • Decreased appetite 7%
  • Fatigued 6%
  • Sleep difficulty 5%
  • Dizziness 4%
  • Fatigue 4%
More Cymbalta side effects »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Blurred vision 11%
  • Nausea 8%
  • Fatigue 7%
  • Skin condition/edema 6%
  • Headache 6%
More Oleptro side effects »
How it works
CymbaltaOleptro
Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
CymbaltaOleptro
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Antidepressant
Serotonin antagonist and reuptake inhibitor
Prescription only
Available as
CymbaltaOleptro
  • Extended release
  • Pill
  • Extended release
Used for (click to learn more)
CymbaltaOleptro
Risk factors for serious side effects
CymbaltaOleptro
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Cymbalta (Duloxetine) risks & warnings »
    • Age 24 years or younger
    • History of seizures
    • Alcoholism
    • Eating disorder
    • Higher dose
    • Drug interactions
      • Age 65 years or older
      • Alcohol
      • Taking other medicines that make you less alert
      Detailed Oleptro (Trazodone) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      CymbaltaOleptro
      • Take with food to avoid upset stomach.
      No food related info.
      Kidneys and liver
      CymbaltaOleptro
      • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
      No kidneys and liver related info.
      Pain
      CymbaltaOleptro
      • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
      No pain related info.
      Upsides and benefits
      CymbaltaOleptro
      • Effective at relieving depression and anxiety symptoms.
      • Lowers relapse rates for depression.
      • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      • Commonly used in lower doses to help treat sleep problems (insomnia).
      • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
      • Fewer sexual side effects than many other antidepressants.
      • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
      • Comes as a generic medication and is cheaper than many other sleep aides.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      Downsides and risks
      CymbaltaOleptro
      • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
      • Not the best option for people with high blood pressure.
      • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      • Not as effective as other medications for depression.
      • More sedating than other antidepressants.
      • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
      • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Tips from our pharmacists for people taking the medication
      CymbaltaOleptro
      • Take with food to avoid upset stomach.
      • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
      • Stop taking slowly to avoid withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • Makes you sleepy. Take at bedtime.
      • Can cause temporary dry mouth and upset stomach.
      • Seek medical attention for unwanted, persistent erection.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      Learn more
      More about CymbaltaSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Cymbalta (Duloxetine)?
      Worth itNot sureNot worth it
      More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Oleptro (Trazodone)?
      Worth itNot sureNot worth it