Compare Cymbalta vs. Prozac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cymbalta (duloxetine)

Prescription only

Prozac (Fluoxetine)

Prescription only
Improves mood and relieves certain types of pain.

Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure.

4.8/ 7 average rating with 496 reviewsforCymbalta
Improves mood and helps you relax.

Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.

4.7/ 7 average rating with 1319 reviewsforProzac
Upsides
  • Cymbalta (duloxetine) may help relieve nerve pain from diabetes and other forms of chronic pain.
  • Cymbalta (duloxetine) has several uses, which may be good for people with multiple conditions.
  • Available as a generic, which is cheaper.
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression and bulimia nervosa.
  • Causes less sleepiness than other antidepressants.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides
  • Cymbalta (duloxetine) may not be a good option if you're a heavy drinker, or have liver or kidney problems.
  • Cymbalta (duloxetine) can increase high blood pressure.
  • Like most antidepressants, Cymbalta (duloxetine) can cause higher risk of suicidal thoughts and behavior for people aged 24 and younger.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
  • More likely than other antidepressants to interact with other medications you're taking.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
  • Delayed release capsule
  • Liquid
Price
Lowest price near you
$16.25
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Lowest price near you
$4
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Reviews
496 
58%
think this treatment is worth it
49%
think this treatment works well
24%
think this treatment is a hassle

Have you used Cymbalta (duloxetine)?

Leave a review
1319 
62%
think this treatment is worth it
40%
think this treatment works well
16%
think this treatment is a hassle

Have you used Prozac (Fluoxetine)?

Leave a review
Side effects
10possible side effects
  • Nausea
    23%
  • Headache
    14%
  • Dry mouth
    13%
  • Drowsiness
    10%
  • Fatigue
    9%
  • Difficulty sleeping
    9%
  • Constipation
    9%
  • Dizziness
    9%
  • Diarrhea
    9%
  • Decreased appetite
    7%
See more detailed side effects
1possible side effects
  • Decreased libido
    4%
See more detailed side effects
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort

  • Withdrawal

    Stopping Cymbalta (duloxetine) abruptly

  • Increased bleeding

    Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)

  • Changes in blood pressure and risk of falls

    Elderly patients

    ...and 4 more risk factors

  • Bipolar disorder

    History of bipolar disorder

    ...and 1 more risk factors

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Withdrawal

    Stopping Prozac (Fluoxetine) suddenly

  • Heart problems

    History of heart problems

    ...and 2 more risk factors

  • Increased bleeding

    Taking other blood-thinning drugs

  • Mania

    History of bipolar disorder

    ...and 1 more risk factors

See more detailed risks and warnings