Compare Cymbalta vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cymbalta
(Duloxetine)

Remeron
(Mirtazapine)

Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.873479318734793Cymbalta
Reviews for Cymbalta (Duloxetine)
59%
of people say Cymbalta (Duloxetine) is worth it
49%
say it works well
24%
say it's a big hassle
Reviews for Remeron (Mirtazapine)
47%
12% vs. Cymbalta (Duloxetine)
42%
7% vs. Cymbalta (Duloxetine)
26%
2% vs. Cymbalta (Duloxetine)
Side effects
CymbaltaRemeron
  • Nausea 15%
  • Dry mouth 8%
  • Drowsiness 8%
  • Constipation 7%
  • Somnolencee 7%
  • Decreased appetite 7%
  • Fatigued 6%
  • Sleep difficulty 5%
  • Dizziness 4%
  • Fatigue 4%
More Cymbalta side effects »
  • Drowsiness 36%
  • Increased appetite 15%
  • Dry mouth 10%
  • Weight gain 10%
  • Constipation 6%
  • Dizziness 4%
  • Muscle weakness 3%
  • Abnormal dreams 3%
  • Flu syndrome 2%
  • Thinking abnormal 2%
More Remeron side effects »
How it works
CymbaltaRemeron
Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
CymbaltaRemeron
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Antidepressant
Noradrenergic and specific serotonergic antidepressant
Prescription only
Available as
CymbaltaRemeron
  • Extended release
  • Pill
  • Dissolving tablet
Used for (click to learn more)
CymbaltaRemeron
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.

After 4 weeks using Start and Cymbalta (Duloxetine), here’s how much better people feel.

After 4 weeks using Start and Remeron (Mirtazapine), here’s how much better people feel.

Risk factors for serious side effects
CymbaltaRemeron
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Cymbalta (Duloxetine) risks & warnings »
    • Age 24 years or younger
    • Using other medications that affect serotonin
    • History of heart problems
    • History of liver problems
    • Higher dose
    • Alcohol
    • Taking other medicines that make you less alert
        Detailed Remeron (Mirtazapine) risks & warnings »
        Pregnancy category
        CymbaltaRemeron
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        • Take with food to avoid upset stomach.
        No specific food-related info.
        Kidneys and liver
        • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
        No specific kidneys and liver-related info.
        Sex
        • Cymbalta (Duloxetine) can cause lower sex drive or difficulty having an orgasm. If the problem persists after the first 2 to 3 months, you can talk to your doctor about alternative antidepressants or performance-enhancing medications.
        No specific sex-related info.
        Sleep
        • Stopping Cymbalta (Duloxetine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3 days of stopping the medication, and go away within 1 to 2 weeks. Work with your doctor to gradually reduce your dose.
        No specific sleep-related info.
        Weight
        No specific weight-related info.
        • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
        • Good option for people who are underweight or frail, because it can help you gain weight.
        • Can increase appetite and weight.
        • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
        Upsides and benefits
        CymbaltaRemeron
        • Effective at relieving depression and anxiety symptoms.
        • Lowers relapse rates for depression.
        • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Effective at relieving some depression symptoms.
        • Starts to work more quickly than most antidepressants.
        • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
        • Good option for people who are underweight or frail, because it can help you gain weight.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        CymbaltaRemeron
        • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
        • Not the best option for people with high blood pressure.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • Not as effective as other medications for depression.
        • More sedating than other antidepressants.
        • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        CymbaltaRemeron
        • Take with food to avoid upset stomach.
        • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
        • Stop taking slowly to avoid withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • Makes you sleepy. Take at bedtime.
        • Can increase appetite and weight.
        • Takes 8 to 12 weeks to see full effects on mood.
        • Stop taking slowly to avoid withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about CymbaltaSide effectsReviews & ratingsAlternativesFDA package insert
        More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert