Compare Cymbalta vs. nefazodone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cymbalta
(duloxetine)

Serzone
(nefazodone)

Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Treats depression. Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.
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Prices and coupon for 30 (60mg) capsules of duloxetine
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Prices and coupon for 60 (100mg) tablets of nefazodone
Reviews & ratings
Filter group. All currently selected
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4.84Cymbalta
Reviews for Cymbalta (duloxetine)
58%
of people (All ages) say Cymbalta (duloxetine) is worth it
49%
say it works well
24%
say it's a big hassle
496 reviews
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Have you used Serzone (nefazodone)?
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Side effects
Cymbaltanefazodone
  • Nausea 15%
  • Headache 2%
  • Dry mouth 8%
  • Somnolencee 7%
  • Fatigue 4%
  • Sleep difficulty 4%
  • Constipation 5%
  • Dizziness 4%
  • Diarrhea 3%
  • Decreased appetite 5%
More Cymbalta side effects »
  • Headache 3%
  • Sleepiness 11%
  • Dry mouth 12%
  • Nausea 10%
  • Dizziness 12%
  • Constipation 6%
  • Weakness 6%
  • Trouble sleeping 2%
  • Lightheadedness 7%
  • Indigestion 2%
More nefazodone side effects »
How it works
Cymbaltanefazodone
Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Serzone (nefazodone) is a serotonin reuptake inhibitor. Serzone (nefazodone) raises the amount of serotonin in the brain, which helps to regulate your mood.
Type of medication
Cymbaltanefazodone
Prescription only
Prescription only
Available as
Cymbaltanefazodone
  • Extended release
  • Pill
Used for
Cymbaltanefazodone
Risk factors for serious side effects
Cymbaltanefazodone
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Cymbalta (duloxetine) risks & warnings »
    • People under age 24
      • Taking medicine for high blood pressure
        • History of seizures
        • History of heart attack or heart disease
        • Medicines that slow the heartbeat
        Detailed Serzone (nefazodone) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Interactions
        Cymbaltanefazodone
        No interactions related info.
        • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
        Food
        Cymbaltanefazodone
        • Take with food to avoid upset stomach.
        No food related info.
        Kidneys and liver
        Cymbaltanefazodone
        • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
        No kidneys and liver related info.
        Pain
        Cymbaltanefazodone
        • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
        • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.
        Upsides and benefits
        Cymbaltanefazodone
        • Effective at relieving depression and anxiety symptoms.
        • Lowers relapse rates for depression.
        • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
        • Serzone (nefazodone) is available in generic.
        Downsides and risks
        Cymbaltanefazodone
        • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
        • Not the best option for people with high blood pressure.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
        • Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
        • It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
        • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
        Tips from our pharmacists for people taking the medication
        Cymbaltanefazodone
        • Take with food to avoid upset stomach.
        • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
        • Stop taking slowly to avoid withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • You may not notice any changes in your mood until you've taken Serzone (nefazodone) for at least 2 weeks. The full effects may not happen for at least 2 to 3 months.
        • Don't drive or do anything requiring concentration until you know how Serzone (nefazodone) affects you because it can make you feel dizzy.
        • If you forget a dose of Serzone (nefazodone), take it as soon as you remember. If it's time for your next dose, don't take 2 doses at the same time to make up for the missed dose.
        • Store Serzone (nefazodone) in your pantry away from heat, light, and moisture.
        • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.
        Learn more
        More about CymbaltaSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Cymbalta (duloxetine)?
        Worth itNot sureNot worth it
        More about nefazodoneSide effectsAlternativesFDA package insert
        Have you used Serzone (nefazodone)?
        Worth itNot sureNot worth it