Compare Cymbalta vs. Tegretol

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Prevents seizures, stabilizes mood, and relieves nerve pain. Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Cymbalta (Duloxetine)
of people say Cymbalta (Duloxetine) is worth it
say it works well
say it's a big hassle
411 reviews
Reviews for Tegretol (Carbamazepine)
1% vs. Cymbalta (Duloxetine)
7% vs. Cymbalta (Duloxetine)
+3% vs. Cymbalta (Duloxetine)
Side effects
  • Nausea 15%
  • Dry mouth 8%
  • Drowsiness 8%
  • Constipation 7%
  • Somnolencee 7%
  • Decreased appetite 7%
  • Fatigued 6%
  • Sleep difficulty 5%
  • Dizziness 4%
  • Fatigue 4%
More Cymbalta side effects »
  • Dizziness 32%
  • Drowsiness 19%
  • Nausea 19%
  • Vomiting 15%
  • Itching 6%
  • Constipation 5%
  • Dry mouth 5%
  • Muscle weakness 4%
  • Blurred vision 4%
  • Rash 3%
More Tegretol side effects »
How it works
Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Tegretol (Carbamazepine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to block certain kinds of nerve activity to reduce seizures and pain.
Type of medication
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
AnticonvulsantPrescription only
Available as
  • Extended release
  • Pill
  • Extended release
  • Chewable tablet
  • Oral suspension
Used for (click to learn more)
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.

After 4 weeks using Start and Cymbalta (Duloxetine), here’s how much better people feel.

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Tegretol (Carbamazepine)
Risk factors for serious side effects
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Cymbalta (Duloxetine) risks & warnings »
    • People also taking Depakote
    • Asian ancestry
      • History of depression
      • European, Chinese, or Japanese ancestry
        • Age 65 years or older
        • Stopping Tegretol (Carbamazepine) suddenly
        Detailed Tegretol (Carbamazepine) risks & warnings »
        Pregnancy category
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        No specific alcohol-related info.No specific alcohol-related info.
        • Take with food to avoid upset stomach.
        No specific food-related info.
        Kidneys and liver
        • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
        No specific kidneys and liver-related info.
        • Cymbalta (Duloxetine) can cause lower sex drive or difficulty having an orgasm. If the problem persists after the first 2 to 3 months, you can talk to your doctor about alternative antidepressants or performance-enhancing medications.
        No specific sex-related info.
        • Stopping Cymbalta (Duloxetine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3 days of stopping the medication, and go away within 1 to 2 weeks. Work with your doctor to gradually reduce your dose.
        No specific sleep-related info.
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        • Effective at relieving depression and anxiety symptoms.
        • Lowers relapse rates for depression.
        • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Lowers the frequency of seizures, especially for people with tonic-clonic and partial seizures.
        • First-line option for trigeminal neuralgia (nerve pain involving the face, head, and neck), and can relieve other types of nerve pain.
        • May be helpful in stabilizing mood for people with bipolar disorder.
        Downsides and risks
        • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
        • Not the best option for people with high blood pressure.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • Interacts with many other medicines and supplements.
        • Higher risk of skin reactions compared to other antiepileptic medicines, ranging from mild to life-threatening rash.
        • Can cause blurry vision, dizziness, and upset stomach.
        • Not safe to use if you're pregnant.
        • Requires routine blood tests to see how the medicine is affecting your body.
        Tips from our pharmacists for people taking the medication
        • Take with food to avoid upset stomach.
        • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
        • Stop taking slowly to avoid withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • For the first week, avoid activities that require you to be alert.
        • Report skin rashes or blistering immediately.
        • Don't use if pregnant.
        • Requires routine blood tests.
        • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
        • Takes up to 5 weeks to feel full effects on mood.
        Learn more
        More about CymbaltaSide effectsReviews & ratingsAlternativesFDA package insert
        More about TegretolSide effectsReviews & ratingsAlternativesFDA package insert