Compare Cymbalta vs. Valium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cymbalta
(duloxetine)

Valium
(diazepam)

Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Helps you relax. Valium (Diazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and for pain and sleeplessness from muscle spasm. Less severe withdrawal symptoms compared to similar drugs.
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Prices and coupon for 30 (60mg) capsules of duloxetine
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Reviews & ratings
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4.84Cymbalta
Reviews for Cymbalta (duloxetine)
58%
of people (All ages) say Cymbalta (duloxetine) is worth it
49%
say it works well
24%
say it's a big hassle
496 reviews
Have you used Cymbalta (duloxetine)?
Worth itNot sureNot worth it
Reviews for Valium (diazepam)
70%
+12% better vs. Cymbalta (duloxetine)
53%
+4% better vs. Cymbalta (duloxetine)
15%
+9% better vs. Cymbalta (duloxetine)
976 reviews
Have you used Valium (diazepam)?
Worth itNot sureNot worth it
Side effects
CymbaltaValium
  • Nausea 15%
  • Headache 2%
  • Dry mouth 8%
  • Somnolencee 7%
  • Fatigue 4%
  • Sleep difficulty 4%
  • Constipation 5%
  • Dizziness 4%
  • Diarrhea 3%
  • Decreased appetite 5%
More Cymbalta side effects »

The Valium FDA package insert doesn’t have numbers about how common side effects are.

More about Valium side effects »
How it works
CymbaltaValium
Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Valium (Diazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.
Type of medication
CymbaltaValium
Prescription only
Prescription only
Available as
CymbaltaValium
  • Extended release
  • Pill
  • Liquid
  • Rectal gel
Used for
CymbaltaValium
Risk factors for serious side effects
CymbaltaValium
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Cymbalta (duloxetine) risks & warnings »
    • Taking more than the prescribed dose
    • Taking longer than 4 weeks
    • History of drug abuse
    • Long-term use
      • Alcohol
      • Taking other medicines that make you less alert
        • Current liver problems
        Detailed Valium (diazepam) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Alcohol
        CymbaltaValium
        No alcohol related info.
        • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
        • Not safe to use with alcohol.
        Food
        CymbaltaValium
        • Take with food to avoid upset stomach.
        No food related info.
        Kidneys and liver
        CymbaltaValium
        • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
        • Processed by the liver, so might not be the best choice if you have liver problems.
        Pain
        CymbaltaValium
        • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
        No pain related info.
        Sleep
        CymbaltaValium
        No sleep related info.
        • Can cause memory problems, drowsiness, dizziness, and confusion.
        • Can cause temporary dizziness and drowsiness.
        Upsides and benefits
        CymbaltaValium
        • Effective at relieving depression and anxiety symptoms.
        • Lowers relapse rates for depression.
        • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Effective at relieving short-term anxiety and sleeplessness.
        • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
        • Effective at relieving muscle spasms caused by a variety of conditions.
        • Less severe withdrawal symptoms compared to other benzodiazepines.
        Downsides and risks
        CymbaltaValium
        • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
        • Not the best option for people with high blood pressure.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • Processed by the liver, so might not be the best choice if you have liver problems.
        • Can cause memory problems, drowsiness, dizziness, and confusion.
        • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
        • Most people find that it gets less effective over time.
        Tips from our pharmacists for people taking the medication
        CymbaltaValium
        • Take with food to avoid upset stomach.
        • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
        • Stop taking slowly to avoid withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • Good for short-term relief of anxiety symptoms.
        • Starts working in 30 minutes when swallowed.
        • Helpful with muscle spasms.
        • Can cause temporary dizziness and drowsiness.
        • Addictive. Long-term use can cause dependence or abuse.
        • Not safe to use with alcohol.
        Learn more
        More about CymbaltaSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Cymbalta (duloxetine)?
        Worth itNot sureNot worth it
        More about ValiumSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Valium (diazepam)?
        Worth itNot sureNot worth it