Compare Cymbalta vs. Viibryd

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cymbalta (duloxetine)

Prescription only

Viibryd (Vilazodone)

Prescription only
Improves mood and relieves certain types of pain.

Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure.

3.6/ 5 average rating with 496 reviewsforCymbalta
Treats depression.

Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.

4.0/ 5 average rating with 95 reviewsforViibryd
Upsides
  • Cymbalta (duloxetine) may help relieve nerve pain from diabetes and other forms of chronic pain.
  • Cymbalta (duloxetine) has several uses, which may be good for people with multiple conditions.
  • Available as a generic, which is cheaper.
  • Viibryd (Vilazodone) improves depressive symptoms in people with major depressive disorder.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
Downsides
  • Cymbalta (duloxetine) may not be a good option if you're a heavy drinker, or have liver or kidney problems.
  • Cymbalta (duloxetine) can increase high blood pressure.
  • Like most antidepressants, Cymbalta (duloxetine) can cause higher risk of suicidal thoughts and behavior for people aged 24 and younger.
  • You shouldn’t take Viibryd (Vilazodone) if you have severe liver problems.
  • Can’t take Viibryd (Vilazodone) with drugs called monoamine oxidase inhibitors (MAOIs).
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
Price
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Reviews
496 reviews so far
58%
saidit'sworth it
49%
saiditworked well
24%
saidit'sa big hassle

Have you used Cymbalta (duloxetine)?

Leave a review
95 reviews so far
67%
saidit'sworth it
63%
saiditworked well
13%
saidit'sa big hassle

Have you used Viibryd (Vilazodone)?

Leave a review
Side effects
12possible side effects
  • Nausea
    23%
  • Headache
    14%
  • Dry mouth
    13%
  • Drowsiness
    10%
  • Fatigue
    9%
  • Difficulty sleeping
    9%
  • Constipation
    9%
  • Dizziness
    9%
  • Diarrhea
    9%
  • Decreased appetite
    7%
  • Excessive sweating
    6%
  • Abdominal pain
    5%
See more detailed side effects
26possible side effects
  • Diarrhea
    28%
  • Nausea
    23%
  • Dizziness
    9%
  • Dry mouth
    8%
  • Insomnia
    6%
  • Vomiting
    5%
  • Decreased libido
    5%
  • Abnormal dreams
    4%
  • Libido decreased
    4%
  • Fatigue
    4%
  • Abnormal orgasm
    4%
  • Dyspepsia
    3%
  • Flatulence
    3%
  • Gastroenteritis
    3%
  • Somnolence
    3%
  • Paresthesia
    3%
  • Restlessness
    3%
  • Orgasm abnormal
    3%
  • Arthralgia
    3%
  • Tremor
    2%
  • Feeling jittery
    2%
  • Palpitations
    2%
  • Delayed ejaculation
    2%
  • Erectile dysfunction
    2%
  • Increased appetite
    2%
  • Sexual dysfunction
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
  • Withdrawal
    • Stopping Cymbalta (duloxetine) abruptly
  • Increased bleeding
    • Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
  • Changes in blood pressure and risk of falls
    • Elderly patients
    • History of gait disturbances
    • Taking more than 60 mg of Cymbalta (duloxetine) daily
    • Taking other medicines that lower blood pressure
    • History of high blood pressure
  • Bipolar disorder
    • History of bipolar disorder
    • At risk for bipolar disorder
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 18 years or younger
  • Monoamine oxidase inhibitor (MAOI) interaction
    • Taking Viibryd (Vilazodone) with MAOIs
    • Taking Viibryd (Vilazodone) with Zyvox or methylene blue
  • Serotonin syndrome
    • Taking Viibryd (Vilazodone) with other drugs that increase serotonin
  • Abnormal bleeding
    • Taking Viibryd (Vilazodone) with NSAIDs, warfarin, aspirin, or other drugs that affect clotting
  • Risk to fetus
    • Women of childbearing age
  • Eye problems
    • History of glaucoma
  • Activation of mania/hypomania
    • History of bipolar disorder (mixed/mania)
See more detailed risks and warnings