Compare Dalmane vs. desipramine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dalmane
(flurazepam)

desipramine

Helps you fall asleep. Dalmane (flurazepam) helps you fall asleep, but its effect can carry over to the next day and be addictive.Stabilizes your mood. Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.
Reviews & ratings
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Have you used Dalmane (flurazepam)?
Worth itNot sureNot worth it

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Have you used Norpramin (desipramine)?
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Side effects
Dalmanedesipramine

The Dalmane FDA package insert doesn’t have numbers about how common side effects are.

More about Dalmane side effects »

The desipramine FDA package insert doesn’t have numbers about how common side effects are.

More about desipramine side effects »
How it works
Dalmanedesipramine
Dalmane (flurazepam) is a benzodiazepine. It activates the part of your brain for resting and digesting.Norpramin (desipramine) is a tricyclic antidepressant. It increases the amount of norepinephrine and serotonin in the brain, two chemicals that regulate mood.
Type of medication
Dalmanedesipramine
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
Dalmanedesipramine
  • Capsule
  • Pill
Used for
Dalmanedesipramine
Risk factors for serious side effects
Dalmanedesipramine
  • Alcohol
  • Taking narcotics, tranquilizers or antihistamines
  • Women
  • Over age 65
Detailed Dalmane (flurazepam) risks & warnings »
  • People under age 24
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Norpramin (desipramine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
Dalmanedesipramine
  • Can be dangerous if combined with alcohol or narcotics.
No alcohol related info.
Sleep
Dalmanedesipramine
  • People taking Dalmane (flurazepam) for sleep have reported having difficulty concentrating the next day, and have problems driving or operating machinery. Talk to your doctor if this is a problem.
  • Can make you feel sleepy and unable to concentrate the next day. This hangover effect is especially worse for women and elderly.
No sleep related info.
Upsides and benefits
Dalmanedesipramine
  • Dalmane (flurazepam) works 15-30 minutes after taking it.
  • Dalmane (flurazepam) is available in generic.
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
Downsides and risks
Dalmanedesipramine
  • Can make you feel sleepy and unable to concentrate the next day. This hangover effect is especially worse for women and elderly.
  • Should only be used short-term because it can be addicting.
  • Can cause sleep-walking or other sleep-related activities that you may not remember doing the next day.
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
Tips from our pharmacists for people taking the medication
Dalmanedesipramine
  • Can be dangerous if combined with alcohol or narcotics.
  • Effect lasts long and may carry into the next morning. Take Dalmane (flurazepam) only if you expect to be in bed for full 7-8 hours.
  • Can cause rebound insomnia if you stop taking it, especially if you've been on it for a while.
  • Can cause sleep walking or doing other behaviors while asleep. Talk to your doctor right away if this happens.
  • Don't drive or do anything requiring concentration until you know how Norpramin (desipramine) affects you since it can make you feel sleepy.
  • Talk to your doctor right away if your mood suddenly darkens and you want to hurt yourself while taking Norpramin (desipramine).
  • If you're being switched to Norpramin (desipramine) from monoamine oxidase inhibitors, you'll need to wait 2 weeks before you can start it.
  • Don't stop taking Norpramin (desipramine) suddenly without talking to your doctor first.
Learn more
More about DalmaneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Dalmane (flurazepam)?
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More about desipramineSide effectsAlternativesFDA package insert
Have you used Norpramin (desipramine)?
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