Compare Dantrium vs. Oxybutynin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dantrium
(dantrolene)

Oxytrol
(oxybutynin)

Relaxes your muscles. Dantrium (dantrolene) effectively treats malignant hyperthermia (increased temperature and muscle contractions when receiving anesthesia) and is the only medicine used to treat the condition. Dantrium (dantrolene) is not a first-choice treatment for general muscle spasms because it can damage your liver.Treats an overactive bladder. Oxytrol (Oxybutynin) is a good treatment for overactive bladder, but watch out for side effects such as dry mouth and constipation.
Reviews & ratings
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Have you used Dantrium (dantrolene)?
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Have you used Oxytrol (oxybutynin)?
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Side effects
DantriumOxybutynin

The Dantrium FDA package insert doesn’t have numbers about how common side effects are.

More about Dantrium side effects »

We haven’t found good data for Oxybutynin side effects.

FDA side effect reports for Oxybutynin »
How it works
DantriumOxybutynin
Dantrium (dantrolene) stops spasms and relaxes muscle cells by interfering with the release of calcium inside muscle cells.Oxytrol (Oxybutynin) is an anticholinergic. It relaxes the bladder muscles by lowering muscle spasms. This helps people go to the bathroom less often and better control their urination.
Type of medication
DantriumOxybutynin
Prescription onlyPrescription only
Available as
DantriumOxybutynin
  • Pill
  • Injection
  • Pill
  • Extended release
  • Liquid
  • Cream, gel, or ointment
  • Patch
Used for
DantriumOxybutynin
  • Malignant Hyperthermia
Risk factors for serious side effects
DantriumOxybutynin
  • Taking 800 mg or more Dantrium (dantrolene) per day
  • Women
  • Over 35 years old
  • Elderly
  • History of liver disease or dysfunction
Detailed Dantrium (dantrolene) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Outside in hot weather
  • Dehydrated
  • Exercising
Detailed Oxytrol (oxybutynin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
DantriumOxybutynin
No alcohol related info.
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
Food
DantriumOxybutynin
No food related info.
  • Can be taken with or without food.
Sleep
DantriumOxybutynin
  • Taking Dantrium (dantrolene) may make you feel dizzy or sleepy for the first few days, especially if you drink alcohol or take recreational drugs. Avoid driving or other activities requiring concentration until you know how your body responds to the medication. Your body should adjust to the medicine. Talk to your doctor or pharmacist if these symptoms bother you.
  • Dantrium (dantrolene) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Oxytrol (Oxybutynin) can cause drowsiness, confusion, dizziness, hallucinations, or blurred vision. Avoid driving, operating machinery, or doing anything that requires you to be alert until you know how Oxytrol (Oxybutynin) affects you.
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
Upsides and benefits
DantriumOxybutynin
  • Dantrium (dantrolene) effectively treats malignant hyperthermia.
  • Can be used for muscle spasticity if other medications haven't worked.
  • Available as generic.
  • Oxytrol (Oxybutynin) is effective at treating overactive bladder by lowering the urge to urinate, and helping to better control urination.
  • Available in multiple forms: a patch, gel, extended-release tablet, and tablet.
  • The gel form of Oxytrol (Oxybutynin) is available over the counter without a prescription.
  • Oxytrol (Oxybutynin) patch and gel have fewer side effects than taking the tablet.
  • The tablet is available as a generic.
Downsides and risks
DantriumOxybutynin
  • Not a first-choice treatment for muscle spasms because it can cause liver damage.
  • Can cause dizziness, sleepiness, and sometimes severe diarrhea.
  • Needs routine blood tests since it can injure your liver.
  • Dose needs to be increased slowly to minimize side effects.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
  • Can’t be used if you have uncontrolled narrow-angle glaucoma.
  • Not recommended if you have ulcerative colitis or certain other stomach problems since Oxytrol (Oxybutynin) can slow stomach emptying.
  • Not the best choice if you have GERD (acid reflux), since Oxytrol (Oxybutynin) can irritate your throat and make the acid reflux worse.
  • Has more side effects than newer medicines that treat overactive bladder.
Tips from our pharmacists for people taking the medication
DantriumOxybutynin
  • Dantrium (dantrolene) can worsen liver function.You may need to have your blood checked regularly before starting Dantrium (dantrolene) and while you're on it.
  • Dantrium (dantrolene) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Dantrium (dantrolene) can cause diarrhea, but it usually goes away within the first few weeks. If it doesn't, talk to your doctor.
  • May make your skin sensitive to the sun. Wear sunblock and avoid prolonged exposure to sunlight while on Dantrium (dantrolene).
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
  • Can be taken with or without food.
  • Let your doctor know if your symptoms don’t get better in two weeks. There could be other causes of your bladder problems or you may need to try a different medicine.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
Learn more
More about DantriumSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Dantrium (dantrolene)?
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More about OxybutyninSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oxytrol (oxybutynin)?
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