Compare Dantrium vs. Vesicare

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dantrium
(dantrolene)

Vesicare
(solifenacin)

Relaxes your muscles. Dantrium (dantrolene) effectively treats malignant hyperthermia (increased temperature and muscle contractions when receiving anesthesia) and is the only medicine used to treat the condition. Dantrium (dantrolene) is not a first-choice treatment for general muscle spasms because it can damage your liver.Treats an overactive bladder. Vesicare (Solifenacin) is a good treatment for overactive bladder and doesn’t have as many side effects as similar medications.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Dantrium (dantrolene)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Vesicare (solifenacin)?
Worth itNot sureNot worth it
Side effects
DantriumVesicare

The Dantrium FDA package insert doesn’t have numbers about how common side effects are.

More about Dantrium side effects »
  • Dry mouth 7%
  • Constipation 2%
  • Vision blurred 2%
  • Abdominal pain upper 1%
  • Flu 1%
  • Indigestion 3%
  • Dry eyes nos 1%
More Vesicare side effects »
How it works
DantriumVesicare
Dantrium (dantrolene) stops spasms and relaxes muscle cells by interfering with the release of calcium inside muscle cells.Vesicare (Solifenacin) is an anticholinergic. It relaxes the bladder muscles by lowering muscle spasms. This helps people go to the bathroom less often and better control their urination.
Type of medication
DantriumVesicare
Prescription onlyPrescription only
Available as
DantriumVesicare
  • Pill
  • Injection
  • Pill
Used for
DantriumVesicare
  • Malignant Hyperthermia
Risk factors for serious side effects
DantriumVesicare
  • Taking 800 mg or more Dantrium (dantrolene) per day
  • Women
  • Over 35 years old
  • Elderly
  • History of liver disease or dysfunction
Detailed Dantrium (dantrolene) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Outside in hot weather
  • Dehydrated
  • Exercising
Detailed Vesicare (solifenacin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
DantriumVesicare
No interactions related info.
  • Has some drug interactions, so make sure your doctor has your complete list of medications.
Alcohol
DantriumVesicare
No alcohol related info.
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
Food
DantriumVesicare
No food related info.
  • Can be taken with or without food.
  • Can be taken with or without food.
Sleep
DantriumVesicare
  • Taking Dantrium (dantrolene) may make you feel dizzy or sleepy for the first few days, especially if you drink alcohol or take recreational drugs. Avoid driving or other activities requiring concentration until you know how your body responds to the medication. Your body should adjust to the medicine. Talk to your doctor or pharmacist if these symptoms bother you.
  • Dantrium (dantrolene) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Vesicare (Solifenacin) can cause drowsiness, confusion, dizziness, hallucinations, or blurred vision. Avoid driving, operating machinery, or doing anything that requires you to be alert until you know how Vesicare (Solifenacin) affects you.
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
Upsides and benefits
DantriumVesicare
  • Dantrium (dantrolene) effectively treats malignant hyperthermia.
  • Can be used for muscle spasticity if other medications haven't worked.
  • Available as generic.
  • Vesicare (Solifenacin) is effective at treating overactive bladder by lowering the urge to urinate, and helping to better control urination.
  • Can be taken with or without food.
  • Causes fewer side effects than other medications in the same drug class.
  • Only needs to be taken once a day.
Downsides and risks
DantriumVesicare
  • Not a first-choice treatment for muscle spasms because it can cause liver damage.
  • Can cause dizziness, sleepiness, and sometimes severe diarrhea.
  • Needs routine blood tests since it can injure your liver.
  • Dose needs to be increased slowly to minimize side effects.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
  • Can’t be used if you have uncontrolled narrow-angle glaucoma.
  • Not recommended if you have ulcerative colitis or certain other gastrointestinal problems, since Vesicare (Solifenacin) can slow stomach emptying.
  • Has some drug interactions, so make sure your doctor has your complete list of medications.
  • Not available as a generic.
Tips from our pharmacists for people taking the medication
DantriumVesicare
  • Dantrium (dantrolene) can worsen liver function.You may need to have your blood checked regularly before starting Dantrium (dantrolene) and while you're on it.
  • Dantrium (dantrolene) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Dantrium (dantrolene) can cause diarrhea, but it usually goes away within the first few weeks. If it doesn't, talk to your doctor.
  • May make your skin sensitive to the sun. Wear sunblock and avoid prolonged exposure to sunlight while on Dantrium (dantrolene).
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
  • Can be taken with or without food.
  • Let your doctor know if your symptoms don’t get better in two weeks. There could be other causes of your bladder problems or you may need to try a different medicine.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
Learn more
More about DantriumSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Dantrium (dantrolene)?
Worth itNot sureNot worth it
More about VesicareSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vesicare (solifenacin)?
Worth itNot sureNot worth it