Compare DayQuil Cold and Flu vs. Advil Congestion Relief

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dayquil Cold And Flu
(Acetaminophen / Phenylephrine / Dextromethorphan)

Advil Congestion Relief
(Ibuprofen / Phenylephrine)

Relieves cold and flu symptoms. Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a useful combination medicine that relieves cold and flu symptoms, but make sure you really need all of its ingredients.Relieves pain and congestion. Advil Congestion Relief (Ibuprofen / Phenylephrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.092502434274587DayQuil Cold and Flu
Reviews for Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan)
81%
of people say Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is worth it
37%
say it works well
5%
say it's a big hassle
Reviews for Advil Congestion Relief (Ibuprofen / Phenylephrine)
73%
8% vs. Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan)
32%
5% vs. Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan)
7%
2% vs. Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan)
Side effects
DayQuil Cold and FluAdvil Congestion Relief

We haven’t found good data for DayQuil Cold and Flu side effects.

FDA side effect reports for DayQuil Cold and Flu »

We haven’t found good data for Advil Congestion Relief side effects.

FDA side effect reports for Advil Congestion Relief »
How it works
DayQuil Cold and FluAdvil Congestion Relief
Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Advil Congestion Relief (Ibuprofen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Ibuprofen is an NSAID that relieves swelling, pain, and fever. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
DayQuil Cold and FluAdvil Congestion Relief
Pain reliever
APAP
DecongestantCough suppressantOver-the-counter
Pain reliever
NSAID
DecongestantOver-the-counter
Available as
DayQuil Cold and FluAdvil Congestion Relief
  • Pill
  • Liquid
  • Pill
Used for (click to learn more)
DayQuil Cold and FluAdvil Congestion Relief
Risk factors for serious side effects
DayQuil Cold and FluAdvil Congestion Relief
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • Using other medications that affect serotonin
  • Women of childbearing age
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
Detailed Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) risks & warnings »
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Women of childbearing age
  • History of high blood pressure
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • History of heart problems
  • Age 65 years or older
  • Taking with aspirin
Detailed Advil Congestion Relief (Ibuprofen / Phenylephrine) risks & warnings »
Pregnancy category
DayQuil Cold and FluAdvil Congestion Relief
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.
  • Advil Congestion Relief (Ibuprofen / Phenylephrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Congestion Relief (Ibuprofen / Phenylephrine) for any amount of time.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
DayQuil Cold and FluAdvil Congestion Relief
  • Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Advil Congestion Relief (Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
Downsides and risks
DayQuil Cold and FluAdvil Congestion Relief
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • You shouldn't use it if you have high blood pressure.
  • If you don't really need both of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
  • You shouldn't use it if you have high blood pressure.
Tips from our pharmacists for people taking the medication
DayQuil Cold and FluAdvil Congestion Relief
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
  • Follow age-specific dosing instructions on how much to take.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Starts working in 30 minutes.
  • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Follow age-specific dosing instructions on how much to take. Don't take more than what's recommended on the package.
  • Let your doctor know if your symptoms don't improve in a few days.
Learn more
More about DayQuil Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert
More about Advil Congestion ReliefSide effectsReviews & ratingsAlternativesFDA package insert