Compare DayQuil Cold and Flu vs. Mucinex D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dayquil Cold And Flu
(Acetaminophen / Phenylephrine / Dextromethorphan)

Mucinex D
(Guaifenesin / Pseudoephedrine)

Relieves cold and flu symptoms. Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a useful combination medicine that relieves cold and flu symptoms, but make sure you really need all of its ingredients.Breaks up mucus and relieves congestion. Mucinex D (Guaifenesin / Pseudoephedrine) is good if you have a stuffy nose and a cough with mucus, but it could keep you up at night.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.092502434274587DayQuil Cold and Flu
Reviews for Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan)
81%
of people say Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is worth it
37%
say it works well
5%
say it's a big hassle
Reviews for Mucinex D (Guaifenesin / Pseudoephedrine)
76%
5% vs. Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan)
41%
+4% vs. Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan)
7%
2% vs. Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan)
Side effects
DayQuil Cold and FluMucinex D

We haven’t found good data for DayQuil Cold and Flu side effects.

FDA side effect reports for DayQuil Cold and Flu »

We haven’t found good data for Mucinex D side effects.

FDA side effect reports for Mucinex D »
How it works
DayQuil Cold and FluMucinex D
Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine. Guaifenesin (an expectorant) breaks up and thins out mucus. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
DayQuil Cold and FluMucinex D
Pain reliever
APAP
DecongestantCough suppressantOver-the-counter
ExpectorantDecongestantOver-the-counter
Available as
DayQuil Cold and FluMucinex D
  • Pill
  • Liquid
  • Extended release
Used for (click to learn more)
DayQuil Cold and FluMucinex D
Risk factors for serious side effects
DayQuil Cold and FluMucinex D
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • Using other medications that affect serotonin
  • Women of childbearing age
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
Detailed Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) risks & warnings »
  • History of high blood pressure
  • History of heart problems
  • Age 65 years or older
    Detailed Mucinex D (Guaifenesin / Pseudoephedrine) risks & warnings »
    Pregnancy category
    DayQuil Cold and FluMucinex D
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    DayQuil Cold and FluMucinex D
    • Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
    • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
    • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
    • Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have sinus and chest congestion.
    • Helps loosen the mucus in your airways so that you can cough it up more easily.
    • Works well to clear nasal congestion and help you breathe better.
    Downsides and risks
    DayQuil Cold and FluMucinex D
    • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
    • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
    • You shouldn't use it if you have high blood pressure.
    • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
    • Pseudoephedrine, the decongestant in Mucinex D (Guaifenesin / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
    • Doesn't work as well if you use it for more than 4 days at a time.
    • Although you don't need a prescription to get Mucinex D (Guaifenesin / Pseudoephedrine), you need to show a photo ID to buy it in the drugstore.
    • Mucinex D (Guaifenesin / Pseudoephedrine) isn’t useful if you have a dry cough.
    Tips from our pharmacists for people taking the medication
    DayQuil Cold and FluMucinex D
    • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
    • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
    • Follow age-specific dosing instructions on how much to take.
    • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
    • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
    • Drink plenty of fluids while taking Mucinex D (Guaifenesin / Pseudoephedrine) because liquid helps break down mucus.
    • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
    • You need to show an ID to buy Mucinex D (Guaifenesin / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
    • Don't take Mucinex D (Guaifenesin / Pseudoephedrine) too close to bedtime since it can keep you awake.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    Learn more
    More about DayQuil Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert
    More about Mucinex DSide effectsReviews & ratingsAlternativesFDA package insert