Compare DayQuil Cold and Flu vs. Mucinex DM

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dayquil Cold And Flu
(Acetaminophen / Phenylephrine / Dextromethorphan)

Mucinex Dm
(Dextromethorphan / Guaifenesin)

Relieves cold and flu symptoms. Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a useful combination medicine that relieves cold and flu symptoms, but make sure you really need all of its ingredients.Breaks up mucus and relieves cough. Mucinex Dm (Dextromethorphan / Guaifenesin) is okay for loosening congestion in your chest and throat, but it could prevent you from coughing the mucus up. It comes as an extended-release tablet and a short-acting liquid.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.092502434274587DayQuil Cold and Flu
Reviews for Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan)
81%
of people say Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is worth it
37%
say it works well
5%
say it's a big hassle

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Side effects
DayQuil Cold and FluMucinex DM

We haven’t found good data for DayQuil Cold and Flu side effects.

FDA side effect reports for DayQuil Cold and Flu »

We haven’t found good data for Mucinex DM side effects.

FDA side effect reports for Mucinex DM »
How it works
DayQuil Cold and FluMucinex DM
Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine. Guaifenesin is an expectorant that breaks up and thins out mucus. Dextromethorphan is a cough suppressant.
Type of medication
DayQuil Cold and FluMucinex DM
Pain reliever
APAP
DecongestantCough suppressantOver-the-counter
Cough suppressantExpectorantOver-the-counter
Available as
DayQuil Cold and FluMucinex DM
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Liquid
Used for (click to learn more)
DayQuil Cold and FluMucinex DM
Risk factors for serious side effects
DayQuil Cold and FluMucinex DM
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • Using other medications that affect serotonin
  • Women of childbearing age
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
Detailed Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) risks & warnings »
    • Using other medications that affect serotonin
      Detailed Mucinex Dm (Dextromethorphan / Guaifenesin) risks & warnings »
      Pregnancy category
      DayQuil Cold and FluMucinex DM
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      DayQuil Cold and FluMucinex DM
      • Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
      • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
      • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
      • Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have chest congestion and a cough.
      • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
      • The extended release version of Mucinex DM lasts up to 12 hours.
      Downsides and risks
      DayQuil Cold and FluMucinex DM
      • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
      • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
      • You shouldn't use it if you have high blood pressure.
      • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
      • Mucinex Dm (Dextromethorphan / Guaifenesin) isn’t useful if you have a dry cough without mucus or phlegm.
      • The two medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan (the "DM" in Mucinex Dm (Dextromethorphan / Guaifenesin)) stops you from coughing.
      • Can cause sleepiness, dizziness, and an upset stomach.
      Tips from our pharmacists for people taking the medication
      DayQuil Cold and FluMucinex DM
      • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
      • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
      • Follow age-specific dosing instructions on how much to take.
      • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
      • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
      • Cough suppressant starts working in 15 to 30 minutes.
      • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
      • Drink plenty of fluids while taking Mucinex Dm (Dextromethorphan / Guaifenesin) because liquid helps break down mucus.
      • If your cough lasts more than 7 days, call your doctor.
      Learn more
      More about DayQuil Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert
      More about Mucinex DMSide effectsReviews & ratingsAlternativesFDA package insert