Compare Delsym vs. Dayquil Cold And Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves coughing.

Delsym (Dextromethorphan) is a good option for treating dry cough. It's not safe to take with MAO inhibitors though.

3.3/ 5 average rating with 127 reviewsforDelsym
Relieves cold and flu symptoms.

Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a useful combination medicine that relieves cold and flu symptoms, but make sure you really need all of its ingredients.

3.7/ 5 average rating with 1034 reviewsforDayquil Cold And Flu
Upsides
  • Good for treating dry cough.
  • Available in drugstores either by itself or in combination with other medications to treat cold and allergy symptoms.
  • Available as a liquid and a tablet.
  • Some products relieve cough for up to 12 hours.
  • Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
Downsides
  • Can't take dextromethorphan if you're taking MAO inhibitors (drugs used to treat Parkinson's disease, depression, and other emotional conditions). If taken together, they will cause dangerously high blood pressure levels.
  • If you're taking this in combination with other cold and allergy medications, you should read labels closely to make sure you're not accidentally taking too much of a single ingredient.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Used for
Dosage forms
  • Pill
  • Liquid extended release
  • Pill
  • Liquid
No pricing information available
No pricing information available
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Reviews
127 reviews so far
63%
saidit'sworth it
32%
saiditworked well
12%
saidit'sa big hassle

Have you used Delsym (Dextromethorphan)?

Leave a review
1034 reviews so far
81%
saidit'sworth it
38%
saiditworked well
5%
saidit'sa big hassle

Have you used Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan)?

Leave a review
Side effects
The Delsym (Dextromethorphan) FDA package insert doesn’t have numbers about how common side effects are.
The Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serotonin syndrome
    • Using other medications that affect serotonin
See more detailed risks and warnings
  • Liver damage
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
  • High blood pressure
    • History of high blood pressure
    • Taking MAO inhibitors
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Harm to fetus
    • Women of childbearing age
  • Chronic cough
    • History of chronic obstructive pulmonary disease (COPD)
    • History of smoking
See more detailed risks and warnings