Compare Delsym vs. Mucinex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Delsym
(Dextromethorphan)

Mucinex
(Guaifenesin)

Relieves coughing. Delsym (Dextromethorphan) is a good option for treating dry cough. It's not safe to take with MAO inhibitors though.Breaks up mucus that causes cough. Mucinex (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, and it lasts longer than other guaifenesin products.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.487394957983193Delsym
Reviews for Delsym (Dextromethorphan)
64%
of people say Delsym (Dextromethorphan) is worth it
31%
say it works well
12%
say it's a big hassle
Reviews for Mucinex (Guaifenesin)
78%
+14% vs. Delsym (Dextromethorphan)
47%
+16% vs. Delsym (Dextromethorphan)
7%
+5% vs. Delsym (Dextromethorphan)
Side effects
DelsymMucinex

We haven’t found good data for Delsym side effects.

FDA side effect reports for Delsym »

We haven’t found good data for Mucinex side effects.

FDA side effect reports for Mucinex »
How it works
DelsymMucinex
Delsym (Dextromethorphan) is a cough suppressant.Mucinex (Guaifenesin) is an expectorant. It contains guaifenesin, which thins and loosens mucus, making it easier to cough out.
Type of medication
DelsymMucinex
Cough suppressantOver-the-counter
ExpectorantOver-the-counter
Available as
DelsymMucinex
  • Pill
  • Liquid extended release
  • Extended release
  • Liquid
Used for (click to learn more)
DelsymMucinex
Risk factors for serious side effects
DelsymMucinex
  • Using other medications that affect serotonin
Detailed Delsym (Dextromethorphan) risks & warnings »
    Detailed Mucinex (Guaifenesin) risks & warnings »
    Pregnancy category
    DelsymMucinex
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.
    • Mucinex (Guaifenesin) is alcohol- and sugar-free.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    DelsymMucinex
    • Good for treating dry cough.
    • Available in drugstores either by itself or in combination with other medications to treat cold and allergy symptoms.
    • Available as a liquid and a tablet.
    • Some products relieve cough for up to 12 hours.
    • Mucinex (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
    • Lasts longer than some other products that contain guaifenesin, such as Robitussin, because it's an extended-release form.
    • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
    • Available in liquid and tablet forms.
    • Mucinex (Guaifenesin) is alcohol- and sugar-free.
    Downsides and risks
    DelsymMucinex
    • Can't take dextromethorphan if you're taking MAO inhibitors (drugs used to treat Parkinson's disease, depression, and other emotional conditions). If taken together, they will cause dangerously high blood pressure levels.
    • If you're taking this in combination with other cold and allergy medications, you should read labels closely to make sure you're not accidentally taking too much of a single ingredient.
    • Mucinex (Guaifenesin) is more expensive than other medications that treat congestion.
    • You need to drink a lot of fluids while taking this medication or it won't work as well.
    • Mucinex (Guaifenesin) isn’t useful if you have a dry cough.
    • Can cause nausea, headache, and an upset stomach.
    Tips from our pharmacists for people taking the medication
    DelsymMucinex
    • Cough suppressant starts working in 15 to 30 minutes.
    • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
    • If your cough lasts more than 7 days, call your doctor.
    • Drink plenty of fluids while taking Mucinex (Guaifenesin) because liquid helps break down mucus.
    • Steam from a humidifier, cool mist vaporizer, or hot shower can also help add moisture to your airways.
    • Follow age-specific dosing instructions on how much to take.
    • Mucinex (Guaifenesin) only works for coughs with mucus, so don't use it if you have a dry cough.
    • If your cough lasts more than 7 days, call your doctor.
    Learn more
    More about DelsymSide effectsReviews & ratingsAlternativesFDA package insert
    More about MucinexSide effectsReviews & ratingsAlternativesFDA package insert