Compare Delsym vs. Mucinex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Delsym (Dextromethorphan)

Over-the-counter

Mucinex (Guaifenesin)

Over-the-counter
Relieves coughing.

Delsym (Dextromethorphan) is a good option for treating dry cough. It's not safe to take with MAO inhibitors though.

4.5/ 7 average rating with 127 reviewsforDelsym
Breaks up mucus that causes cough.

Mucinex (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, and it lasts longer than other guaifenesin products.

5.2/ 7 average rating with 902 reviewsforMucinex
Upsides
  • Good for treating dry cough.
  • Available in drugstores either by itself or in combination with other medications to treat cold and allergy symptoms.
  • Available as a liquid and a tablet.
  • Some products relieve cough for up to 12 hours.
  • Mucinex (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
  • Lasts longer than some other products that contain guaifenesin, such as Robitussin, because it's an extended-release form.
  • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
  • Available in liquid and tablet forms.
  • Mucinex (Guaifenesin) is alcohol- and sugar-free.
Downsides
  • Can't take dextromethorphan if you're taking MAO inhibitors (drugs used to treat Parkinson's disease, depression, and other emotional conditions). If taken together, they will cause dangerously high blood pressure levels.
  • If you're taking this in combination with other cold and allergy medications, you should read labels closely to make sure you're not accidentally taking too much of a single ingredient.
  • Mucinex (Guaifenesin) is more expensive than other medications that treat congestion.
  • You need to drink a lot of fluids while taking this medication or it won't work as well.
  • Mucinex (Guaifenesin) isn’t useful if you have a dry cough.
  • Can cause nausea, headache, and an upset stomach.
Used for
Dosage forms
  • Pill
  • Liquid extended release
  • Extended release
  • Liquid
No pricing information available
No pricing information available
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
127 
63%
think this treatment is worth it
32%
think this treatment works well
12%
think this treatment is a hassle

Have you used Delsym (Dextromethorphan)?

Leave a review
902 
78%
think this treatment is worth it
47%
think this treatment works well
7%
think this treatment is a hassle

Have you used Mucinex (Guaifenesin)?

Leave a review
Side effects
The Delsym (Dextromethorphan) FDA package insert doesn’t have numbers about how common side effects are.
The Mucinex (Guaifenesin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Serotonin syndrome

    Using other medications that affect serotonin

See more detailed risks and warnings