Compare Delsym vs. Robitussin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Delsym
(dextromethorphan)

Robitussin
(guaifenesin)

Relieves coughing. Delsym (Dextromethorphan) is a good option for treating dry cough. It's not safe to take with MAO inhibitors though.Breaks up mucus that causes cough. Robitussin (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, but it doesn't last as long as other guaifenesin products.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.5Delsym
Reviews for Delsym
63%
of people (All ages) say Delsym is worth it
32%
say it works well
12%
say it's a big hassle
127 reviews
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Have you used Robitussin (guaifenesin)?
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Side effects
DelsymRobitussin

We haven’t found good data for Delsym side effects.

FDA side effect reports for Delsym »

We haven’t found good data for Robitussin side effects.

FDA side effect reports for Robitussin »
How it works
DelsymRobitussin
Delsym (Dextromethorphan) is a cough suppressant.Robitussin (Guaifenesin) is an expectorant. It contains guaifenesin, which thins and loosens mucus, making it easier to cough out.
Type of medication
DelsymRobitussin
Over-the-counterOver-the-counter
Available as
DelsymRobitussin
  • Pill
  • Liquid extended release
  • Liquid
Used for
DelsymRobitussin
Risk factors for serious side effects
DelsymRobitussin
  • Using other medications that affect serotonin
Detailed Delsym (dextromethorphan) risks & warnings »
    Detailed Robitussin (guaifenesin) risks & warnings »
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Upsides and benefits
    DelsymRobitussin
    • Good for treating dry cough.
    • Available in drugstores either by itself or in combination with other medications to treat cold and allergy symptoms.
    • Available as a liquid and a tablet.
    • Some products relieve cough for up to 12 hours.
    • Robitussin (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
    • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
    • Available in multiple forms.
    • Can be used in children 12 years and older.
    Downsides and risks
    DelsymRobitussin
    • Can't take dextromethorphan if you're taking MAO inhibitors (drugs used to treat Parkinson's disease, depression, and other emotional conditions). If taken together, they will cause dangerously high blood pressure levels.
    • If you're taking this in combination with other cold and allergy medications, you should read labels closely to make sure you're not accidentally taking too much of a single ingredient.
    • Robitussin (Guaifenesin) doesn't last as long as other products that contain guaifenesin. Mucinex's extended release form lasts 12 hours and Robitussin (Guaifenesin)'s lasts 8 hours.
    • You need to drink a lot of fluids while taking this medication or it won't work as well.
    • Robitussin (Guaifenesin) isn’t useful if you have a dry cough.
    • Can cause nausea, headache, and an upset stomach.
    Tips from our pharmacists for people taking the medication
    DelsymRobitussin
    • Cough suppressant starts working in 15 to 30 minutes.
    • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
    • If your cough lasts more than 7 days, call your doctor.
    • Drink plenty of fluids while taking Robitussin (Guaifenesin) because liquid helps break down mucus.
    • Steam from a humidifier, cool mist vaporizer, or hot shower can also help add moisture to your airways.
    • Follow age-specific dosing instructions on how much to take.
    • If your cough lasts more than 7 days, call your doctor.
    • Robitussin (Guaifenesin) only works for coughs with mucus, so don't use it if you have a dry cough.
    Learn more
    More about DelsymSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Delsym (dextromethorphan)?
    Worth itNot sureNot worth it
    More about RobitussinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Robitussin (guaifenesin)?
    Worth itNot sureNot worth it