Compare Delsym vs. Unisom

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves coughing.

Delsym (Dextromethorphan) is a good option for treating dry cough. It's not safe to take with MAO inhibitors though.

3.3/ 5 average rating with 127 reviewsforDelsym
Treats allergy symptoms and helps you sleep.

Unisom Sleeptabs (Doxylamine) can help you get a good night's sleep, but you can have a hard time waking up if you don't give yourself enough time to sleep.

3.3/ 5 average rating with 585 reviewsforUnisom
Upsides
  • Good for treating dry cough.
  • Available in drugstores either by itself or in combination with other medications to treat cold and allergy symptoms.
  • Available as a liquid and a tablet.
  • Some products relieve cough for up to 12 hours.
  • Works well to help you fall asleep and doesn't make you feel groggy the next morning.
  • Has fewer side effects than prescription sleep aid medications.
  • Available over the counter without a prescription.
  • Not habit-forming like other sleep aids can be.
Downsides
  • Can't take dextromethorphan if you're taking MAO inhibitors (drugs used to treat Parkinson's disease, depression, and other emotional conditions). If taken together, they will cause dangerously high blood pressure levels.
  • If you're taking this in combination with other cold and allergy medications, you should read labels closely to make sure you're not accidentally taking too much of a single ingredient.
  • Shouldn't be used unless you have a full night to sleep.
  • You shouldn't drive after taking Unisom Sleeptabs (Doxylamine) until you know how it affects you.
  • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
  • It can increase the risk of falls, so elderly people shouldn't use Unisom Sleeptabs (Doxylamine).
Used for
Dosage forms
  • Pill
  • Liquid extended release
  • Pill
  • Chewable tablet
  • Liquid
No pricing information available
No pricing information available
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Reviews
127 reviews so far
63%
saidit'sworth it
32%
saiditworked well
12%
saidit'sa big hassle

Have you used Delsym (Dextromethorphan)?

Leave a review
585 reviews so far
58%
saidit'sworth it
32%
saiditworked well
11%
saidit'sa big hassle

Have you used Unisom Sleeptabs (Doxylamine)?

Leave a review
Side effects
The Delsym (Dextromethorphan) FDA package insert doesn’t have numbers about how common side effects are.
The Unisom Sleeptabs (Doxylamine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serotonin syndrome
    • Using other medications that affect serotonin
See more detailed risks and warnings
  • Overdosage
    • Using other drugs with similar ingredients
  • Increased side effects
    • Age 65 years or older
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Hyperactivity
    • Children age 6 years or younger
  • Trouble urinating
    • Enlarged prostate
    • History of bladder problems
  • Vision changes
    • Glaucoma
  • Breastfeeding
    • Nursing mothers
See more detailed risks and warnings