Compare Depakote vs. Abilify

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depacon (Valproate, Valproic Acid, Or Divalproex)

Prescription only

Abilify (aripiprazole)

Prescription only
Prevents seizures and stabilizes mood.

Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.

4.4/ 7 average rating with 97 reviewsforDepakote
Helps control your thoughts and mood.

Abilify (aripiprazole) is good for treating psychosis and mania, and can help with depression. It's less likely to cause side effects than other antipsychotics.

4.3/ 7 average rating with 252 reviewsforAbilify
Upsides
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
  • Effective at relieving psychotic symptoms and manic episodes.
  • More energizing than other antipsychotics.
  • Fewer side effects than other antipsychotics.
  • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
  • Available as a generic, which is cheaper.
Downsides
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Mild risk of extrapyramidal symptoms (EPS), a movement disorder that includes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find the one that works for you and that you can tolerate.
Used for
Dosage forms
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
Price
Lowest price near you
$293.48
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Lowest price near you
$35.45
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Reviews
97 
46%
think this treatment is worth it
40%
think this treatment works well
27%
think this treatment is a hassle

Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?

Leave a review
252 
44%
think this treatment is worth it
40%
think this treatment works well
34%
think this treatment is a hassle

Have you used Abilify (aripiprazole)?

Leave a review
Side effects
10possible side effects
  • Nausea
    48%
  • Headache
    31%
  • Asthenia
    27%
  • Vomiting
    27%
  • Somnolence
    27%
  • Tremor
    25%
  • Dizziness
    25%
  • Abdominal Pain
    23%
  • Diplopia
    16%
  • Diarrhea
    13%
See more detailed side effects
The Abilify (aripiprazole) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Liver damage

    Children under age 2

    ...and 1 more risk factors

  • Suicidal thoughts or behavior

    History of depression

  • Mental changes due to high ammonia

    History of metabolic disorders

    ...and 1 more risk factors

  • Low body temperature

    People also taking Topamax

  • Withdrawal seizures

    Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly

See more detailed risks and warnings
  • Increased risk of death

    Elderly patients with dementia

  • Suicidal thoughts or behavior

    Age 24 years or younger

    ...and 1 more risk factors

  • Increased blood sugar and cholesterol, and weight gain

    People with diabetes

    ...and 1 more risk factors

  • Driving impairment

    Alcohol

    ...and 1 more risk factors

See more detailed risks and warnings