Compare Depakote vs. Abilify

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depacon
(valproate, valproic acid, or divalproex)

Abilify
(aripiprazole)

Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.Helps control your thoughts and mood. Abilify (aripiprazole) is good for treating psychosis and mania, and can help with depression. It's less likely to cause side effects than other antipsychotics.
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Coupons for Depakote
Best available price for 60 (500mg) tablets of depakote
Coupons for Abilify
Best available price for 30 (5mg) tablets of abilify
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.44Depakote
Reviews for Depakote
46%
of people (All ages) say Depakote is worth it
40%
say it works well
27%
say it's a big hassle
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
Reviews for Abilify
44%
+2% better vs. Depakote
40%
Same vs. Depakote
34%
+7% better vs. Depakote
252 reviews
Have you used Abilify (aripiprazole)?
Worth itNot sureNot worth it
Side effects
DepakoteAbilify
  • Nausea 7%
  • Drowsiness 7%
  • Dizziness 8%
  • Vomiting 9%
  • Accidental injury 6%
  • Muscle weakness 3%
  • Abdominal pain 1%
  • Indigestion 1%
  • Any side effect 4%
  • Rash 3%
More Depakote side effects »
  • Sleepiness 20%
  • Difficulty controlling movements 17%
  • Fatigue 7%
  • Nausea 7%
  • Restlessness 8%
  • Blurred vision 8%
  • Excess drooling 6%
  • Dizziness 4%
  • Extreme restlessness 21%
  • Sleep difficulty 6%
More Abilify side effects »
How it works
DepakoteAbilify
Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.Abilify (aripiprazole) is an atypical antipsychotic. It stabilizes dopamine and serotonin levels in your brain to help control your thoughts and affect mood.
Type of medication
DepakoteAbilify
Prescription onlyPrescription only
Available as
DepakoteAbilify
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
Used for
DepakoteAbilify
Risk factors for serious side effects
DepakoteAbilify
  • Children under age 2
  • History of metabolic disorders
  • History of depression
  • People also taking Topamax
Detailed Depacon (valproate, valproic acid, or divalproex) risks & warnings »
  • Elderly patients with dementia
  • Age 24 years or younger
  • Use of antidepressant medications
  • People with diabetes
  • People with high cholesterol
Detailed Abilify (aripiprazole) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
DepakoteAbilify
  • Take with food to avoid upset stomach.
No food related info.
Kidneys and liver
DepakoteAbilify
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
No kidneys and liver related info.
Weight
DepakoteAbilify
  • May cause hair loss and weight gain.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Abilify (aripiprazole) can make you gain weight, which can also increase your blood sugar and cholesterol. If you're at risk for diabetes, high blood pressure or high cholestetrol, talk to your doctor how to lower your risk.
Upsides and benefits
DepakoteAbilify
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
  • Effective at relieving psychotic symptoms and manic episodes.
  • More energizing than other antipsychotics.
  • Fewer side effects than other antipsychotics.
  • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
  • Available as a generic, which is cheaper.
Downsides and risks
DepakoteAbilify
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Mild risk of extrapyramidal symptoms (EPS), a movement disorder that includes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find the one that works for you and that you can tolerate.
Tips from our pharmacists for people taking the medication
DepakoteAbilify
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Take with food to avoid upset stomach.
  • May cause hair loss and weight gain.
  • Different versions of Depakote have different dosing. Be careful.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes 3 to 4 weeks to feel full effects on mood.
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Makes you energized. Take in the morning to avoid difficulty sleeping.
  • For the first week, avoid activities that require you to be alert.
  • May increase cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Available in pills that you take daily, and as a monthly injection.
Learn more
More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
More about AbilifySide effectsReviews & ratingsAlternativesFDA package insert
Have you used Abilify (aripiprazole)?
Worth itNot sureNot worth it