Compare Depakote vs. baclofen

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prevents seizures and stabilizes mood.

Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.

3.3/ 5 average rating with 97 reviewsforDepakote
Relaxes your muscles.

Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.

3.5/ 5 average rating with 33 reviewsforbaclofen
Upsides
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
Downsides
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
Used for
Dosage forms
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Reviews
97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?

Leave a review
33 reviews so far
61%
saidit'sworth it
55%
saiditworked well
15%
saidit'sa big hassle

Have you used Lioresal (baclofen)?

Leave a review
Side effects
26possible side effects
  • Nausea
    48%
  • Headache
    31%
  • Asthenia
    27%
  • Vomiting
    27%
  • Somnolence
    27%
  • Tremor
    25%
  • Dizziness
    25%
  • Abdominal Pain
    23%
  • Diplopia
    16%
  • Diarrhea
    13%
  • Anorexia
    12%
  • Amblyopia/Blurred Vision
    12%
  • Flu Syndrome
    12%
  • Infection
    12%
  • Dyspepsia
    8%
  • Ataxia
    8%
  • Nystagmus
    8%
  • Fever
    6%
  • Emotional Lability
    6%
  • Thinking Abnormal
    6%
  • Alopecia
    6%
  • Weight Loss
    6%
  • Constipation
    5%
  • Amnesia
    5%
  • Bronchitis
    5%
  • Rhinitis
    5%
See more detailed side effects
1possible side effects
  • Drowsiness
    63%
See more detailed side effects
Risks and risk factors
  • Pregnancy
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
  • Pancreatitis
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes due to high ammonia
    • History of metabolic disorders
    • People also taking Topamax
  • Low body temperature
    • People also taking Topamax
  • Serious allergic reactions
  • Withdrawal seizures
    • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
See more detailed risks and warnings
  • Withdrawal symptoms
    • Stopping Lioresal (baclofen) too quickly
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Seizures
    • Higher dose
    • Using other medicines that can cause seizures
    • History of seizures
    • Alcoholism
    • Eating disorders
    • Brain infections
See more detailed risks and warnings