Compare Depakote vs. desipramine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depacon (Valproate, Valproic Acid, Or Divalproex)

Prescription only

Norpramin (desipramine)

Prescription only
Prevents seizures and stabilizes mood.

Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.

4.4/ 7 average rating with 97 reviewsforDepakote
Stabilizes your mood.

Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.

Upsides
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
Downsides
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
Used for
Dosage forms
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
Price
Lowest price near you
$293.48
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Lowest price near you
$15.87
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Reviews
97 
46%
think this treatment is worth it
40%
think this treatment works well
27%
think this treatment is a hassle

Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?

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Side effects
10possible side effects
  • Nausea
    48%
  • Headache
    31%
  • Asthenia
    27%
  • Vomiting
    27%
  • Somnolence
    27%
  • Tremor
    25%
  • Dizziness
    25%
  • Abdominal Pain
    23%
  • Diplopia
    16%
  • Diarrhea
    13%
See more detailed side effects
The Norpramin (desipramine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Liver damage

    Children under age 2

    ...and 1 more risk factors

  • Suicidal thoughts or behavior

    History of depression

  • Mental changes due to high ammonia

    History of metabolic disorders

    ...and 1 more risk factors

  • Low body temperature

    People also taking Topamax

  • Withdrawal seizures

    Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly

See more detailed risks and warnings
  • Higher risk of suicide

    People under age 24

  • Serotonin syndrome

    Tricyclic antidepressants

    ...and 5 more risk factors

  • Changes to the heartbeat

    History of heart disease

  • Higher risk for seizures

    History of seizures

    ...and 1 more risk factors

See more detailed risks and warnings