Compare Depakote vs. Keppra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depacon (Valproate, Valproic Acid, Or Divalproex)

Prescription only

Keppra (Levetiracetam)

Prescription only
Prevents seizures and stabilizes mood.

Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.

4.4/ 7 average rating with 97 reviewsforDepakote
Prevents seizures.

Keppra (Levetiracetam) is effective for preventing seizures in people with epilepsy. Compared to other anti-seizure medications, it has few drug interactions and you don’t need to get your levels checked.

6.2/ 7 average rating with 21 reviewsforKeppra
Upsides
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
  • Lowers the frequency of seizures, including partial-onset, generalized tonic-clonic, and myoclonic seizures.
  • Unlike many other medications for epilepsy, this has very few drug interactions, so your other medicines shouldn't be affected.
  • If you have trouble swallowing tablets, Keppra (Levetiracetam) is also available as an oral solution.
  • You won’t need to get regular blood tests to check the drug levels in your body.
Downsides
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • It’s important to take your dose on time so that Keppra (Levetiracetam) has consistent levels in your body.
  • May not be the best drug to take if you have a history of psychiatric issues, such as depression or bipolar disorder.
  • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
  • Keppra (Levetiracetam) is only FDA-approved to be taken with other medicines to treat epilepsy.
Used for
Dosage forms
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
  • Extended release
  • Liquid
Price
Lowest price near you
$293.48
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Lowest price near you
$14.75
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Reviews
97 
46%
think this treatment is worth it
40%
think this treatment works well
27%
think this treatment is a hassle

Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?

Leave a review
21 
33%
think this treatment is worth it
81%
think this treatment works well
33%
think this treatment is a hassle

Have you used Keppra (Levetiracetam)?

Leave a review
Side effects
10possible side effects
  • Nausea
    48%
  • Headache
    31%
  • Asthenia
    27%
  • Vomiting
    27%
  • Somnolence
    27%
  • Tremor
    25%
  • Dizziness
    25%
  • Abdominal Pain
    23%
  • Diplopia
    16%
  • Diarrhea
    13%
See more detailed side effects
9possible side effects
  • Somnolence
    12%
  • Neck pain
    8%
  • Any side effect
    8%
  • Pharyngitis
    7%
  • Vertigo
    5%
  • Influenza
    5%
  • Depression
    5%
  • Anxiety
    3%
  • Depressed mood
    2%
See more detailed side effects
Risks and warnings
  • Liver damage

    Children under age 2

    ...and 1 more risk factors

  • Suicidal thoughts or behavior

    History of depression

  • Mental changes due to high ammonia

    History of metabolic disorders

    ...and 1 more risk factors

  • Low body temperature

    People also taking Topamax

  • Withdrawal seizures

    Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    History of depression

  • Driving impairment

    Starting the first month of therapy

    ...and 2 more risk factors

  • Withdrawal seizures

    Stopping Keppra (Levetiracetam) suddenly

  • Psychiatric side effects

    History of psychiatric problems

    ...and 1 more risk factors

See more detailed risks and warnings