Compare Depakote vs. Keppra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depacon
(Valproate, Valproic Acid, Or Divalproex)

Keppra
(Levetiracetam)

Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.Prevents seizures. Keppra (Levetiracetam) is effective for preventing seizures in people with epilepsy. Compared to other anti-seizure medications, it has few drug interactions and you don’t need to get your levels checked.
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Reviews & ratings
Filter group. All currently selected
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4.376344086021505Depakote
Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
46%
of people (All ages) say Depacon (Valproate, Valproic Acid, Or Divalproex) is worth it
39%
say it works well
27%
say it's a big hassle
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Have you used Keppra (Levetiracetam)?
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Side effects
DepakoteKeppra
  • Nausea 34%
  • Muscle weakness 20%
  • Vomiting 20%
  • Abdominal pain 17%
  • Dizziness 12%
  • Headache 10%
  • Double vision 7%
  • Involuntary eye movement 7%
  • Lack of muscle coordination 7%
  • Accidental injury 6%
More Depakote side effects »
  • Drowsiness 7%
  • Nasal congestion 7%
  • Muscle weakness 6%
  • Neck pain 6%
  • Decreased appetite 6%
  • Fatigue 6%
  • Infection 5%
  • Aggression 5%
  • Dizziness 5%
  • Headache 4%
More Keppra side effects »
How it works
DepakoteKeppra
Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.Keppra (Levetiracetam) is an antiepileptic medication. It prevents seizures by helping regulate neurotransmitters in the brain.
Type of medication
DepakoteKeppra
AnticonvulsantPrescription only
AnticonvulsantPrescription only
Available as
DepakoteKeppra
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
  • Extended release
  • Liquid
Used for (click to learn more)
DepakoteKeppra
Risk factors for serious side effects
DepakoteKeppra
    • Children under age 2
    • History of metabolic disorders
      • History of depression
        • History of metabolic disorders
        • People also taking Topamax
        • People also taking Topamax
          • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
          Detailed Depacon (Valproate, Valproic Acid, Or Divalproex) risks & warnings »
              • History of depression
              • Starting the first month of therapy
              • Taking with alcohol
              • Taking other medicines that make you less alert
              • Stopping Keppra (Levetiracetam) suddenly
              • History of psychiatric problems
              • Ages less than 18
              Detailed Keppra (Levetiracetam) risks & warnings »
              Pregnancy

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Food
              DepakoteKeppra
              • Take with food to avoid upset stomach.
              No food related info.
              Kidneys and liver
              DepakoteKeppra
              • Can cause liver damage, so it's probably not safe if you already have liver problems.
              • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
              Sleep
              DepakoteKeppra
              No sleep related info.
              • You can experience drowsiness, weakness, dizziness, or respiratory infections while on this.
              • Taking Keppra (Levetiracetam) can make you feel sleepy, dizzy, and affect your coordination. Avoid activities that require you to be alert, such as driving a car or operating machinery, until you know how Keppra (Levetiracetam) affects you.
              Weight
              DepakoteKeppra
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • May cause hair loss and weight gain.
              No weight related info.
              Upsides and benefits
              DepakoteKeppra
              • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
              • One of the first-line options to stabilize mood for people with bipolar disorder.
              • Helpful in preventing frequent migraine headaches.
              • Lowers the frequency of seizures, including partial-onset, generalized tonic-clonic, and myoclonic seizures.
              • Unlike many other medications for epilepsy, this has very few drug interactions, so your other medicines shouldn't be affected.
              • If you have trouble swallowing tablets, Keppra (Levetiracetam) is also available as an oral solution.
              • You won’t need to get regular blood tests to check the drug levels in your body.
              Downsides and risks
              DepakoteKeppra
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • Can cause liver damage, so it's probably not safe if you already have liver problems.
              • Not safe to use if you're pregnant.
              • Requires routine blood tests to see how the medicine is affecting your body.
              • It’s important to take your dose on time so that Keppra (Levetiracetam) has consistent levels in your body.
              • May not be the best drug to take if you have a history of psychiatric issues, such as depression or bipolar disorder.
              • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
              • Keppra (Levetiracetam) is only FDA-approved to be taken with other medicines to treat epilepsy.
              Tips from our pharmacists for people taking the medication
              DepakoteKeppra
              • For the first week, avoid activities that require you to be alert.
              • Don't use if pregnant.
              • Requires routine blood tests.
              • Take with food to avoid upset stomach.
              • May cause hair loss and weight gain.
              • Different versions of Depakote have different dosing. Be careful.
              • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
              • Takes 3 to 4 weeks to feel full effects on mood.
              • You can experience drowsiness, weakness, dizziness, or respiratory infections while on this.
              • If you start having skin rashes or changes in your mood, tell your doctor immediately.
              • If you need to stop taking Keppra (Levetiracetam), do so over at least one week to prevent withdrawal seizures.
              • If you are taking the oral solution, use the measuring device given with the medicine. Don’t use your household tablespoons to measure.
              • Don’t crush or cut this medicine before taking it, or else you’ll have dangerously high levels of this drug in your body.
              Learn more
              More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?
              Worth itNot sureNot worth it
              More about KeppraSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Keppra (Levetiracetam)?
              Worth itNot sureNot worth it