Compare Depakote vs. Latuda

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depacon
(valproate, valproic acid, or divalproex)

Latuda
(lurasidone)

Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.Helps control your thoughts and mood. Latuda (Lurasidone) is good for treating schizophrenia and depression related to bipolar disorder. It's less likely to cause weight gain, cholesterol, blood sugar, and heart rhythm problems.
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Coupons for Depakote
Best available price for 60 (500mg) tablets of depakote
Coupons for Latuda
Best available price for 30 (40mg) tablets of latuda
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.44Depakote
Reviews for Depakote
46%
of people (All ages) say Depakote is worth it
40%
say it works well
27%
say it's a big hassle
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
Reviews for Latuda
61%
-15% worse vs. Depakote
61%
-21% worse vs. Depakote
25%
-2% worse vs. Depakote
Have you used Latuda (lurasidone)?
Worth itNot sureNot worth it
Side effects
DepakoteLatuda
  • Nausea 7%
  • Drowsiness 7%
  • Dizziness 8%
  • Vomiting 9%
  • Accidental injury 6%
  • Muscle weakness 3%
  • Abdominal pain 1%
  • Indigestion 1%
  • Any side effect 4%
  • Rash 3%
More Depakote side effects »
  • Drowsiness 12%
  • Restlessness 12%
  • Nausea 6%
  • Parkinsonism 6%
  • Any side effect 3%
  • Indigestion 2%
  • Vomiting 2%
  • Sleep difficulty 1%
  • Anxiety 3%
  • Agitation 3%
More Latuda side effects »
How it works
DepakoteLatuda
Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.Latuda (Lurasidone) is a second generation antipsychotic. It treats schizophrenia and bipolar depression by adjusting the levels of dopamine and serotonin in your brain, which affects thoughts and mood.
Type of medication
DepakoteLatuda
Prescription onlyPrescription only
Available as
DepakoteLatuda
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
Used for
DepakoteLatuda
Risk factors for serious side effects
DepakoteLatuda
  • Children under age 2
  • History of metabolic disorders
  • History of depression
  • People also taking Topamax
Detailed Depacon (valproate, valproic acid, or divalproex) risks & warnings »
  • Elderly patients with dementia
  • Age 18 years or younger
  • Duration of treatment
  • Taking with alcohol
  • Taking other medicines that make you less alert
Detailed Latuda (lurasidone) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
DepakoteLatuda
No alcohol related info.
  • Need to avoid drinking alcohol while taking Latuda (Lurasidone).
Food
DepakoteLatuda
  • Take with food to avoid upset stomach.
  • Latuda (Lurasidone) can increase your blood sugar and cholesterol. However, Latuda (Lurasidone) is the least likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
Kidneys and liver
DepakoteLatuda
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
No kidneys and liver related info.
Weight
DepakoteLatuda
  • May cause hair loss and weight gain.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
No weight related info.
Upsides and benefits
DepakoteLatuda
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
  • Has been shown in clinical studies to help people felt better and experience improvements with their thoughts and mood.
  • It’s a newer type of medication and works differently than traditional antidepressants.
  • Can be taken alone or with other medications that manage your mood.
  • Compared to other antipsychotics, it has a lower risk of causing weight gain and changes to cholesterol, blood sugar, and heart rhythm.
Downsides and risks
DepakoteLatuda
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Certain antifungal and heart medicines can increase the amount of Latuda (Lurasidone) in your body and put you at risk for more side effects. Ask your doctor or pharmacist about any drug interactions between medicines you’re taking.
  • Can cause you to be more sensitive to heat and make it harder for your body to cool off.
  • Need to avoid drinking alcohol while taking Latuda (Lurasidone).
  • Elderly people who have dementia shouldn't take Latuda (Lurasidone).
Tips from our pharmacists for people taking the medication
DepakoteLatuda
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Take with food to avoid upset stomach.
  • May cause hair loss and weight gain.
  • Different versions of Depakote have different dosing. Be careful.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes 3 to 4 weeks to feel full effects on mood.
  • Take it once a day at the same time each day. It works faster when you take it with a small snack (at least 350 calories).
  • Don’t eat grapefruit or drink grapefruit juice while taking Latuda (Lurasidone). It can negatively affect how Latuda (Lurasidone) works.
  • Can cause dizziness and nausea, so avoid activities that require you to be alert until you get used to it.
  • Usually takes 4 to 6 weeks to see the full effects on your thoughts and mood, so hang in there until you find the right dose that works for you.
Learn more
More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
More about LatudaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Latuda (lurasidone)?
Worth itNot sureNot worth it