Compare Depakote vs. Lidocaine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

(Valproate, Valproic Acid, Or Divalproex)


Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.Treats nerve pain. Lidoderm (Lidocaine) patches work well by releasing a local anesthetic into the skin and relieving pain by targeting damaged nerves.
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Reviews & ratings
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Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
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Side effects
  • Nausea 34%
  • Muscle weakness 20%
  • Vomiting 20%
  • Abdominal pain 17%
  • Dizziness 12%
  • Headache 10%
  • Double vision 7%
  • Involuntary eye movement 7%
  • Lack of muscle coordination 7%
  • Accidental injury 6%
More Depakote side effects »

The Lidocaine FDA package insert doesn’t have numbers about how common side effects are.

More about Lidocaine side effects »
How it works
Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.Lidoderm (Lidocaine) is a local anesthetic. It absorbs into your skin where it targets damaged nerves and relieves burning pain.
Type of medication
AnticonvulsantPrescription only
Local anestheticPrescription only
Available as
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Cream, gel, or ointment
  • Jelly
  • Spray
  • Topical solution
  • Patch
Used for (click to learn more)
Risk factors for serious side effects
    • Children under age 2
    • History of metabolic disorders
      • History of depression
        • History of metabolic disorders
        • People also taking Topamax
        • People also taking Topamax
          • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
          Detailed Depacon (Valproate, Valproic Acid, Or Divalproex) risks & warnings »
          • Use of heating pad on skin
          • Applying patch to red, irritated or broken skin
          • Leaving patch on for more than 12 hours
          • Using patch on a very large area
          • Older age and lower body weight
          • Liver disease
          • Allergy to numbing medications (local anesthetics)
          • Not disposing of Lidoderm (Lidocaine) correctly
          • Children and pets can reach medication
          • Not washing hands after touching or applying Lidoderm (Lidocaine)
          • Applying Lidoderm (Lidocaine) to warm skin
          • Covering patch with wrap or heating pad
          • History of heart problems
          • Using Lidoderm (Lidocaine) with drugs to treat irregular heartbeat
          Detailed Lidoderm (Lidocaine) risks & warnings »
          Pregnancy category
          DFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          No specific alcohol-related info.No specific alcohol-related info.
          • Take with food to avoid upset stomach.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          No specific sex-related info.No specific sex-related info.
          No specific sleep-related info.No specific sleep-related info.
          • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
          • May cause hair loss and weight gain.
          No specific weight-related info.
          Upsides and benefits
          • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
          • One of the first-line options to stabilize mood for people with bipolar disorder.
          • Helpful in preventing frequent migraine headaches.
          • Lidoderm (Lidocaine) can treat pain better for people who can't take oral pain medications due to allergies or bad side effects.
          • Has been shown to relieve nerve pain due to shingles for up to 12 hours at a time.
          • Patches can be cut into smaller pieces to best fit the areas of skin they need to be used on.
          Downsides and risks
          • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
          • Can cause liver damage, so it's probably not safe if you already have liver problems.
          • Not safe to use if you're pregnant.
          • Requires routine blood tests to see how the medicine is affecting your body.
          • Can cause skin irritation after using it the first time, but for most people it's mild and goes away in a few minutes or hours.
          • Used patches contain enough medicine to be dangerous to children and pets, so store and dispose of the patches in a safe place out of their reach.
          • Might not be the best choice if you've had allergic reactions to numbing medications (local anesthetics) in the past.
          • Even though only small amounts of Lidoderm (Lidocaine) are absorbed into the body through the skin, if you're taking medications that treat arrhythmias, Lidoderm (Lidocaine) can affect how they work.
          • Patches shouldn't be left on for more than 12 hours, used on very large areas of skin, or covered with a heating pad.
          Tips from our pharmacists for people taking the medication
          • For the first week, avoid activities that require you to be alert.
          • Don't use if pregnant.
          • Requires routine blood tests.
          • Take with food to avoid upset stomach.
          • May cause hair loss and weight gain.
          • Different versions of Depakote have different dosing. Be careful.
          • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
          • Takes 3 to 4 weeks to feel full effects on mood.
          • Starts working with the first dose, but full effects can take longer.
          • Remove the protective lining on the patch before applying the patch to unbroken skin.
          • Leave the patch on for up to 12 hours during a 24 hour period.
          • You can cut the patches to create a custom fit for the area of skin you need to apply it to.
          • Don't place any tight wraps or heating pads over the patch while it's on.
          • Make sure not to touch your eyes after touching the patch. Always wash your hands after putting it on or taking it off.
          Learn more
          More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
          More about LidocaineSide effectsReviews & ratingsAlternativesFDA package insert