Compare Depakote vs. Lidocaine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depacon (Valproate, Valproic Acid, Or Divalproex)

Prescription only

Lidoderm (Lidocaine)

Prescription only
Prevents seizures and stabilizes mood.

Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.

4.4/ 7 average rating with 97 reviewsforDepakote
Treats nerve pain.

Lidoderm (Lidocaine) patches work well by releasing a local anesthetic into the skin and relieving pain by targeting damaged nerves.

5.8/ 7 average rating with 18 reviewsforLidocaine
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
  • Lidoderm (Lidocaine) can treat pain better for people who can't take oral pain medications due to allergies or bad side effects.
  • Has been shown to relieve nerve pain due to shingles for up to 12 hours at a time.
  • Patches can be cut into smaller pieces to best fit the areas of skin they need to be used on.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Can cause skin irritation after using it the first time, but for most people it's mild and goes away in a few minutes or hours.
  • Used patches contain enough medicine to be dangerous to children and pets, so store and dispose of the patches in a safe place out of their reach.
  • Might not be the best choice if you've had allergic reactions to numbing medications (local anesthetics) in the past.
  • Even though only small amounts of Lidoderm (Lidocaine) are absorbed into the body through the skin, if you're taking medications that treat arrhythmias, Lidoderm (Lidocaine) can affect how they work.
  • Patches shouldn't be left on for more than 12 hours, used on very large areas of skin, or covered with a heating pad.
Used for
Dosage forms
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Cream, gel, or ointment
  • Jelly
  • Spray
  • Topical solution
  • Patch
Lowest price near you
Find instant savings
Lowest price near you
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
think this treatment is worth it
think this treatment works well
think this treatment is a hassle

Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?

Leave a review
think this treatment is worth it
think this treatment works well
think this treatment is a hassle

Have you used Lidoderm (Lidocaine)?

Leave a review
Side effects
10possible side effects
  • Nausea
  • Headache
  • Asthenia
  • Vomiting
  • Somnolence
  • Tremor
  • Dizziness
  • Abdominal Pain
  • Diplopia
  • Diarrhea
See more detailed side effects
The Lidoderm (Lidocaine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Liver damage

    Children under age 2

    ...and 1 more risk factors

  • Suicidal thoughts or behavior

    History of depression

  • Mental changes due to high ammonia

    History of metabolic disorders

    ...and 1 more risk factors

  • Low body temperature

    People also taking Topamax

  • Withdrawal seizures

    Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly

See more detailed risks and warnings
  • Overdose

    Use of heating pad on skin

    ...and 5 more risk factors

  • Serious allergic reaction

    Allergy to numbing medications (local anesthetics)

  • Accidental poisoning

    Not disposing of Lidoderm (Lidocaine) correctly

    ...and 1 more risk factors

  • Eye irritation

    Not washing hands after touching or applying Lidoderm (Lidocaine)

  • Skin reactions

    Applying Lidoderm (Lidocaine) to warm skin

    ...and 1 more risk factors

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

See more detailed risks and warnings