Compare Depakote vs. Myrbetriq

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depacon
(valproate, valproic acid, or divalproex)

Myrbetriq
(mirabegron)

Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.Treats overactive bladder. Myrbetriq (mirabegron) is a good treatment for overactive bladder with the least chance for dry mouth and constipation, but talk to your doctor if you have high blood pressure.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.44Depakote
Reviews for Depakote
46%
of people (All ages) say Depakote is worth it
40%
say it works well
27%
say it's a big hassle
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Myrbetriq (mirabegron)?
Worth itNot sureNot worth it
Side effects
DepakoteMyrbetriq
  • Nausea 7%
  • Drowsiness 7%
  • Dizziness 8%
  • Vomiting 9%
  • Accidental injury 6%
  • Muscle weakness 3%
  • Abdominal pain 1%
  • Indigestion 1%
  • Any side effect 4%
  • Rash 3%
More Depakote side effects »
  • High blood pressure 3%
  • Common cold symptoms 1%
  • Urinary tract infection 2%
  • Constipation 1%
  • Joint pain 1%
  • Rapid heart beat 1%
More Myrbetriq side effects »
How it works
DepakoteMyrbetriq
Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.Myrbetriq (mirabegron) is a beta-3 receptor agonist. It activates the receptor in your bladder, causing the bladder muscles to relax. This allows you to hold more urine and go to the bathroom less often.
Type of medication
DepakoteMyrbetriq
Prescription onlyPrescription only
Available as
DepakoteMyrbetriq
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Extended release
Used for
DepakoteMyrbetriq
Risk factors for serious side effects
DepakoteMyrbetriq
  • Children under age 2
  • History of metabolic disorders
  • History of depression
  • People also taking Topamax
Detailed Depacon (valproate, valproic acid, or divalproex) risks & warnings »
  • Untreated high blood pressure
  • Bladder outlet obstruction
Detailed Myrbetriq (mirabegron) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
DepakoteMyrbetriq
  • Take with food to avoid upset stomach.
  • You can take Myrbetriq (mirabegron) with or without food. If it upsets your stomach, take it with food.
Kidneys and liver
DepakoteMyrbetriq
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not recommended if you have severe liver or kidney disease.
Sleep
DepakoteMyrbetriq
No sleep related info.
  • Myrbetriq (mirabegron) causes less drowsiness and constipation than other medicines for overactive bladder.
Weight
DepakoteMyrbetriq
  • May cause hair loss and weight gain.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
No weight related info.
Upsides and benefits
DepakoteMyrbetriq
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
  • Myrbetriq (mirabegron) helps you to have better control over your urination.
  • Myrbetriq (mirabegron) causes less drowsiness and constipation than other medicines for overactive bladder.
  • May be used if you have glaucoma.
  • Myrbetriq (mirabegron) may be safer to use if you are over 65 years old.
Downsides and risks
DepakoteMyrbetriq
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Myrbetriq (mirabegron) might raise your blood pressure.
  • If you have an obstruction in your bladder, Myrbetriq (mirabegron) might make you retain more urine.
  • Myrbetriq (mirabegron) may be very expensive depending on your insurance.
  • Not recommended if you have severe liver or kidney disease.
Tips from our pharmacists for people taking the medication
DepakoteMyrbetriq
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Take with food to avoid upset stomach.
  • May cause hair loss and weight gain.
  • Different versions of Depakote have different dosing. Be careful.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes 3 to 4 weeks to feel full effects on mood.
  • Myrbetriq (mirabegron) is a long-acting medicine. Do not crush, break or chew it.
  • Drink enough water to keep hydrated. Not drinking enough water on hot days can increase your chances of dehydration or heat stroke.
  • You can take Myrbetriq (mirabegron) with or without food. If it upsets your stomach, take it with food.
  • Drinking too much caffeine in coffee or sodas can make the side effects worse.
  • Check your blood pressure regularly while on Myrbetriq (mirabegron).
Learn more
More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
More about MyrbetriqSide effectsAlternativesFDA package insert
Have you used Myrbetriq (mirabegron)?
Worth itNot sureNot worth it