Compare Depakote vs. Norpramin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depacon
(Valproate, Valproic Acid, Or Divalproex)

Norpramin
(Desipramine)

Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.Coming soon.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.376344086021505Depakote
Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
46%
of people (All ages) say Depacon (Valproate, Valproic Acid, Or Divalproex) is worth it
39%
say it works well
27%
say it's a big hassle
Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?
Worth itNot sureNot worth it

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Have you used Norpramin (Desipramine)?
Worth itNot sureNot worth it
Side effects
DepakoteNorpramin
  • Nausea 34%
  • Muscle weakness 20%
  • Vomiting 20%
  • Abdominal pain 17%
  • Dizziness 12%
  • Headache 10%
  • Double vision 7%
  • Involuntary eye movement 7%
  • Lack of muscle coordination 7%
  • Accidental injury 6%
More Depakote side effects »

We haven’t found good data for Norpramin side effects.

FDA side effect reports for Norpramin »
How it works
DepakoteNorpramin
Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.Coming soon.
Type of medication
DepakoteNorpramin
AnticonvulsantPrescription only
Coming soon.
Available as
DepakoteNorpramin
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
Used for (click to learn more)
DepakoteNorpramin
  • Depression
Risk factors for serious side effects
DepakoteNorpramin
    • Children under age 2
    • History of metabolic disorders
      • History of depression
        • History of metabolic disorders
        • People also taking Topamax
        • People also taking Topamax
          • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
          Detailed Depacon (Valproate, Valproic Acid, Or Divalproex) risks & warnings »
          Coming soon.
          Pregnancy

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

          Food
          DepakoteNorpramin
          • Take with food to avoid upset stomach.
          No food related info.
          Kidneys and liver
          DepakoteNorpramin
          • Can cause liver damage, so it's probably not safe if you already have liver problems.
          No kidneys and liver related info.
          Weight
          DepakoteNorpramin
          • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
          • May cause hair loss and weight gain.
          No weight related info.
          Upsides and benefits
          DepakoteNorpramin
          • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
          • One of the first-line options to stabilize mood for people with bipolar disorder.
          • Helpful in preventing frequent migraine headaches.
          Coming soon
          Downsides and risks
          DepakoteNorpramin
          • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
          • Can cause liver damage, so it's probably not safe if you already have liver problems.
          • Not safe to use if you're pregnant.
          • Requires routine blood tests to see how the medicine is affecting your body.
          Coming soon
          Tips from our pharmacists for people taking the medication
          DepakoteNorpramin
          • For the first week, avoid activities that require you to be alert.
          • Don't use if pregnant.
          • Requires routine blood tests.
          • Take with food to avoid upset stomach.
          • May cause hair loss and weight gain.
          • Different versions of Depakote have different dosing. Be careful.
          • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
          • Takes 3 to 4 weeks to feel full effects on mood.
          Coming soon
          Learn more
          More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?
          Worth itNot sureNot worth it
          More about NorpraminSide effectsReviews & ratingsFDA package insert
          Have you used Norpramin (Desipramine)?
          Worth itNot sureNot worth it