Compare Depakote vs. Pamelor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prevents seizures and stabilizes mood.

Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.

3.3/ 5 average rating with 97 reviewsforDepakote
Improves your mood.

Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.

4.0/ 5 average rating with 19 reviewsforPamelor
Upsides
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
Downsides
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
Used for
Dosage forms
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?

Leave a review
19 reviews so far
79%
saidit'sworth it
79%
saiditworked well
21%
saidit'sa big hassle

Have you used Pamelor (Nortriptyline)?

Leave a review
Side effects
26possible side effects
  • Nausea
    48%
  • Headache
    31%
  • Asthenia
    27%
  • Vomiting
    27%
  • Somnolence
    27%
  • Tremor
    25%
  • Dizziness
    25%
  • Abdominal Pain
    23%
  • Diplopia
    16%
  • Diarrhea
    13%
  • Anorexia
    12%
  • Amblyopia/Blurred Vision
    12%
  • Flu Syndrome
    12%
  • Infection
    12%
  • Dyspepsia
    8%
  • Ataxia
    8%
  • Nystagmus
    8%
  • Fever
    6%
  • Emotional Lability
    6%
  • Thinking Abnormal
    6%
  • Alopecia
    6%
  • Weight Loss
    6%
  • Constipation
    5%
  • Amnesia
    5%
  • Bronchitis
    5%
  • Rhinitis
    5%
See more detailed side effects
The Pamelor (Nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Pregnancy
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
  • Pancreatitis
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes due to high ammonia
    • History of metabolic disorders
    • People also taking Topamax
  • Low body temperature
    • People also taking Topamax
  • Serious allergic reactions
  • Withdrawal seizures
    • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Low blood pressure
    • Age 65 years or older
  • Withdrawal
    • Stopping Pamelor (Nortriptyline) suddenly
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Heart problems
    • History of heart disease
    • Older age
    • Electrolyte imbalance
See more detailed risks and warnings