Compare Depakote vs. Tegretol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depacon
(Valproate, Valproic Acid, Or Divalproex)

Tegretol
(Carbamazepine)

Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.Prevents seizures, stabilizes mood, and relieves nerve pain. Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.376344086021505Depakote
Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
46%
of people say Depacon (Valproate, Valproic Acid, Or Divalproex) is worth it
39%
say it works well
27%
say it's a big hassle
Reviews for Tegretol (Carbamazepine)
58%
+12% vs. Depacon (Valproate, Valproic Acid, Or Divalproex)
42%
+3% vs. Depacon (Valproate, Valproic Acid, Or Divalproex)
21%
+6% vs. Depacon (Valproate, Valproic Acid, Or Divalproex)
Side effects
DepakoteTegretol
  • Nausea 34%
  • Muscle weakness 20%
  • Vomiting 20%
  • Abdominal pain 17%
  • Dizziness 12%
  • Headache 10%
  • Double vision 7%
  • Involuntary eye movement 7%
  • Lack of muscle coordination 7%
  • Accidental injury 6%
More Depakote side effects »
  • Dizziness 32%
  • Drowsiness 19%
  • Nausea 19%
  • Vomiting 15%
  • Itching 6%
  • Constipation 5%
  • Dry mouth 5%
  • Muscle weakness 4%
  • Blurred vision 4%
  • Rash 3%
More Tegretol side effects »
How it works
DepakoteTegretol
Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.Tegretol (Carbamazepine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to block certain kinds of nerve activity to reduce seizures and pain.
Type of medication
DepakoteTegretol
AnticonvulsantPrescription only
AnticonvulsantPrescription only
Available as
DepakoteTegretol
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
  • Extended release
  • Chewable tablet
  • Oral suspension
Used for (click to learn more)
DepakoteTegretol
Risk factors for serious side effects
DepakoteTegretol
    • Children under age 2
    • History of metabolic disorders
      • History of depression
        • History of metabolic disorders
        • People also taking Topamax
        • People also taking Topamax
          • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
          Detailed Depacon (Valproate, Valproic Acid, Or Divalproex) risks & warnings »
          • People also taking Depakote
          • Asian ancestry
            • History of depression
            • European, Chinese, or Japanese ancestry
              • Age 65 years or older
              • Stopping Tegretol (Carbamazepine) suddenly
              Detailed Tegretol (Carbamazepine) risks & warnings »
              Pregnancy category
              DepakoteTegretol
              DFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              DFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              Alcohol
              No specific alcohol-related info.No specific alcohol-related info.
              Food
              • Take with food to avoid upset stomach.
              No specific food-related info.
              Kidneys and liver
              No specific kidneys and liver-related info.No specific kidneys and liver-related info.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • May cause hair loss and weight gain.
              No specific weight-related info.
              Upsides and benefits
              DepakoteTegretol
              • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
              • One of the first-line options to stabilize mood for people with bipolar disorder.
              • Helpful in preventing frequent migraine headaches.
              • Lowers the frequency of seizures, especially for people with tonic-clonic and partial seizures.
              • First-line option for trigeminal neuralgia (nerve pain involving the face, head, and neck), and can relieve other types of nerve pain.
              • May be helpful in stabilizing mood for people with bipolar disorder.
              Downsides and risks
              DepakoteTegretol
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • Can cause liver damage, so it's probably not safe if you already have liver problems.
              • Not safe to use if you're pregnant.
              • Requires routine blood tests to see how the medicine is affecting your body.
              • Interacts with many other medicines and supplements.
              • Higher risk of skin reactions compared to other antiepileptic medicines, ranging from mild to life-threatening rash.
              • Can cause blurry vision, dizziness, and upset stomach.
              • Not safe to use if you're pregnant.
              • Requires routine blood tests to see how the medicine is affecting your body.
              Tips from our pharmacists for people taking the medication
              DepakoteTegretol
              • Take with food to avoid upset stomach.
              • May cause hair loss and weight gain.
              • Different versions of Depakote have different dosing. Be careful.
              • Takes 3 to 4 weeks to feel full effects on mood.
              • For the first week, avoid activities that require you to be alert.
              • Don't use if pregnant.
              • Requires routine blood tests.
              • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
              • Report skin rashes or blistering immediately.
              • Takes up to 5 weeks to feel full effects on mood.
              • For the first week, avoid activities that require you to be alert.
              • Don't use if pregnant.
              • Requires routine blood tests.
              • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
              Learn more
              More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
              More about TegretolSide effectsReviews & ratingsAlternativesFDA package insert