Compare Depakote vs. Tegretol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depacon
(valproate, valproic acid, or divalproex)

Tegretol
(carbamazepine)

Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.Prevents seizures, stabilizes mood, and relieves nerve pain. Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.44Depakote
Reviews for Depakote
46%
of people (All ages) say Depakote is worth it
40%
say it works well
27%
say it's a big hassle
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
Reviews for Tegretol
56%
-10% worse vs. Depakote
43%
-3% worse vs. Depakote
23%
-4% worse vs. Depakote
Have you used Tegretol (carbamazepine)?
Worth itNot sureNot worth it
Side effects
DepakoteTegretol
  • Nausea 7%
  • Somnolence 7%
  • Dizziness 8%
  • Vomiting 9%
  • Accidental injury 6%
  • Asthenia 3%
  • Abdominal Pain 1%
  • Dyspepsia 1%
  • Any side effect 4%
  • Rash 3%
More Depakote side effects »
  • Dizziness 32%
  • Somnolence 19%
  • Nausea 18%
  • Vomiting 15%
  • Ataxia 15%
  • Constipation 5%
  • Pruritus 6%
  • Dry Mouth 5%
  • Asthenia 4%
  • Rash 3%
More Tegretol side effects »
How it works
DepakoteTegretol
Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.Tegretol (Carbamazepine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to block certain kinds of nerve activity to reduce seizures and pain.
Type of medication
DepakoteTegretol
Prescription onlyPrescription only
Available as
DepakoteTegretol
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
  • Extended release
  • Chewable tablet
  • Oral suspension
Used for
DepakoteTegretol
Risk factors for serious side effects
DepakoteTegretol
  • Children under age 2
  • History of metabolic disorders
  • History of depression
  • People also taking Topamax
Detailed Depacon (valproate, valproic acid, or divalproex) risks & warnings »
  • People also taking Depakote
  • Asian ancestry
  • History of depression
  • European, Chinese, or Japanese ancestry
  • Age 65 years or older
Detailed Tegretol (carbamazepine) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
DepakoteTegretol
No interactions related info.
  • Interacts with many other medicines and supplements.
Food
DepakoteTegretol
  • Take with food to avoid upset stomach.
No food related info.
Kidneys and liver
DepakoteTegretol
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
No kidneys and liver related info.
Weight
DepakoteTegretol
  • May cause hair loss and weight gain.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
No weight related info.
Upsides and benefits
DepakoteTegretol
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
  • Lowers the frequency of seizures, especially for people with tonic-clonic and partial seizures.
  • First-line option for trigeminal neuralgia (nerve pain involving the face, head, and neck), and can relieve other types of nerve pain.
  • May be helpful in stabilizing mood for people with bipolar disorder.
Downsides and risks
DepakoteTegretol
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Interacts with many other medicines and supplements.
  • Higher risk of skin reactions compared to other antiepileptic medicines, ranging from mild to life-threatening rash.
  • Can cause blurry vision, dizziness, and upset stomach.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
Tips from our pharmacists for people taking the medication
DepakoteTegretol
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Take with food to avoid upset stomach.
  • May cause hair loss and weight gain.
  • Different versions of Depakote have different dosing. Be careful.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes 3 to 4 weeks to feel full effects on mood.
  • For the first week, avoid activities that require you to be alert.
  • Report skin rashes or blistering immediately.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes up to 5 weeks to feel full effects on mood.
Learn more
More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
More about TegretolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tegretol (carbamazepine)?
Worth itNot sureNot worth it