Compare Depakote vs. Topamax

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depacon
(Valproate, Valproic Acid, Or Divalproex)

Qudexy Xr
(Topiramate)

Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.376344086021505Depakote
Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
46%
of people say Depacon (Valproate, Valproic Acid, Or Divalproex) is worth it
39%
say it works well
27%
say it's a big hassle
Reviews for Qudexy Xr (Topiramate)
54%
+8% vs. Depacon (Valproate, Valproic Acid, Or Divalproex)
52%
+13% vs. Depacon (Valproate, Valproic Acid, Or Divalproex)
33%
6% vs. Depacon (Valproate, Valproic Acid, Or Divalproex)
Side effects
DepakoteTopamax
  • Nausea 34%
  • Muscle weakness 20%
  • Vomiting 20%
  • Abdominal pain 17%
  • Dizziness 12%
  • Headache 10%
  • Double vision 7%
  • Involuntary eye movement 7%
  • Lack of muscle coordination 7%
  • Accidental injury 6%
More Depakote side effects »
  • Tingling sensation 45%
  • Slowed-down thinking and movements 19%
  • Dizziness 17%
  • Drowsiness 17%
  • Fatigue 17%
  • Change in taste 14%
  • Difficulty with concentration/attention 13%
  • Nervousness 12%
  • Difficulty with memory 11%
  • Vision abnormal 11%
More Topamax side effects »
How it works
DepakoteTopamax
Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.
Type of medication
DepakoteTopamax
AnticonvulsantPrescription only
AnticonvulsantPrescription only
Available as
DepakoteTopamax
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
  • Extended release capsule
Used for (click to learn more)
DepakoteTopamax
Risk factors for serious side effects
DepakoteTopamax
    • Children under age 2
    • History of metabolic disorders
      • History of depression
        • History of metabolic disorders
        • People also taking Topamax
        • People also taking Topamax
          • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
          Detailed Depacon (Valproate, Valproic Acid, Or Divalproex) risks & warnings »
          • History of depression
            • Children
            • History of metabolic disorders
            • People also taking Depakote
            • Low-carb diet
            • Dehydration
            • Drug interactions
              • Stopping Qudexy Xr (Topiramate) suddenly
              Detailed Qudexy Xr (Topiramate) risks & warnings »
              Pregnancy category
              DepakoteTopamax
              DFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              DFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              Alcohol
              No specific alcohol-related info.No specific alcohol-related info.
              Food
              • Take with food to avoid upset stomach.
              No specific food-related info.
              Kidneys and liver
              No specific kidneys and liver-related info.
              • A few people will get kidney stones.
              • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • May cause hair loss and weight gain.
              • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
              Upsides and benefits
              DepakoteTopamax
              • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
              • One of the first-line options to stabilize mood for people with bipolar disorder.
              • Helpful in preventing frequent migraine headaches.
              • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
              • Doesn't need routine blood tests.
              • Helpful in preventing frequent migraine headaches.
              Downsides and risks
              DepakoteTopamax
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • Can cause liver damage, so it's probably not safe if you already have liver problems.
              • Requires routine blood tests to see how the medicine is affecting your body.
              • Not safe to use if you're pregnant.
              • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
              • A few people will get kidney stones.
              • Not safe to use if you're pregnant.
              Tips from our pharmacists for people taking the medication
              DepakoteTopamax
              • Requires routine blood tests.
              • Take with food to avoid upset stomach.
              • May cause hair loss and weight gain.
              • Different versions of Depakote have different dosing. Be careful.
              • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
              • For the first week, avoid activities that require you to be alert.
              • Don't use if pregnant.
              • Takes 3 to 4 weeks to feel full effects on mood.
              • Can cause tingling skin sensations and reduced appetite.
              • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
              • For the first week, avoid activities that require you to be alert.
              • Don't use if pregnant.
              • Takes 3 to 4 weeks to feel full effects on mood.
              Learn more
              More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
              More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert