Compare Depakote vs. Vesicare

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prevents seizures and stabilizes mood.

Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.

3.3/ 5 average rating with 97 reviewsforDepakote
Treats overactive bladder.

Vesicare (solifenacin) is a good choice for treatment of overactive bladder if exercises and other behavioral methods haven't worked.

Upsides
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
  • Vesicare (solifenacin) helps you to urinate less often.
  • Its once daily dosing is more convenient than other medicines that work like it.
Downsides
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Can cause drowsiness and increase the risk of falls, especially in the elderly.
  • Not a good option if you have untreated, narrow-angle glaucoma.
Used for
Dosage forms
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
Price
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Reviews
97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

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Side effects
26possible side effects
  • Nausea
    48%
  • Headache
    31%
  • Asthenia
    27%
  • Vomiting
    27%
  • Somnolence
    27%
  • Tremor
    25%
  • Dizziness
    25%
  • Abdominal Pain
    23%
  • Diplopia
    16%
  • Diarrhea
    13%
  • Anorexia
    12%
  • Amblyopia/Blurred Vision
    12%
  • Flu Syndrome
    12%
  • Infection
    12%
  • Dyspepsia
    8%
  • Ataxia
    8%
  • Nystagmus
    8%
  • Fever
    6%
  • Emotional Lability
    6%
  • Thinking Abnormal
    6%
  • Alopecia
    6%
  • Weight Loss
    6%
  • Constipation
    5%
  • Amnesia
    5%
  • Bronchitis
    5%
  • Rhinitis
    5%
See more detailed side effects
8possible side effects
  • Dry mouth
    11%
  • Constipation
    5%
  • Blurry vision
    4%
  • Urinary tract infection
    3%
  • Nausea
    2%
  • Upper abdominal pain
    2%
  • Flu
    2%
  • Dizziness
    2%
See more detailed side effects
Risks and risk factors
  • Pregnancy
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
  • Pancreatitis
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes due to high ammonia
    • History of metabolic disorders
    • People also taking Topamax
  • Low body temperature
    • People also taking Topamax
  • Serious allergic reactions
  • Withdrawal seizures
    • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
See more detailed risks and warnings
  • Tissue swelling
  • Drowsiness
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • People age 65 or older
  • Vision changes
    • Glaucoma
  • Urinary blockage
    • Bladder outflow obstruction
  • Worsening side effects
    • History of kidney problems
    • People age 65 or older
  • Temperature dysregulation
    • Outside in hot weather
    • Dehydrated
    • Exercising
    • Added people 65 and older per Beer's Criteria
    • People age 65 and older
See more detailed risks and warnings